Neuroprotection offered by mesenchymal stem cells in perinatal brain injury: Role of mitochondria, inflammation and reactive oxygen species - Archive ouverte HAL Access content directly
Journal Articles Journal of Neurochemistry Year : 2020

Neuroprotection offered by mesenchymal stem cells in perinatal brain injury: Role of mitochondria, inflammation and reactive oxygen species

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Abstract

Preclinical studies have shown that mesenchymal stem cell have a positive effect in perinatal brain injury models. The mechanisms that cause these neurotherapeutic effects are not entirely intelligible. Mitochondrial damage, inflammation and reactive oxygen species are considered to be critically involved in the development of injury. Mesenchymal stem cells have immunomodulatory action and exert mitoprotective effects which attenuate production of reactive oxygen species and promote restoration of tissue function and metabolism after perinatal insults. This review summarizes the present state, the underlying causes, challenges and possibilities for effective clinical translation of mesenchymal stem cell therapy.

Dates and versions

inserm-03079200 , version 1 (17-12-2020)

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Syam Nair, Eridan Rocha‐ferreira, Bobbi Fleiss, Cora Nijboer, Pierre Gressens, et al.. Neuroprotection offered by mesenchymal stem cells in perinatal brain injury: Role of mitochondria, inflammation and reactive oxygen species. Journal of Neurochemistry, 2020, Online ahead of print. ⟨10.1111/jnc.15267⟩. ⟨inserm-03079200⟩
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