Skip to Main content Skip to Navigation
Journal articles

Outcome of SARS-CoV-2 infection linked to MAIT cell activation and cytotoxicity: evidence for an IL-18 dependent mechanism

Abstract : Immune system dysfunction is paramount in Coronavirus disease 2019 (COVID-19) severity and fatality rate. Mucosal-Associated Invariant T (MAIT) cells are innate-like T cells involved in mucosal immunity and protection against viral infections. Here, we studied the immune cell landscape, with emphasis on MAIT cells, in a cohort of 182 patients including patients at various stages of disease activity. A profound decrease of MAIT cell counts in blood of critically ill patients was observed. These cells showed a strongly activated and cytotoxic phenotype that positively correlated with circulating pro-inflammatory cytokines, notably IL-18. MAIT cell alterations markedly correlated with disease severity and patient mortality. SARS-CoV-2-infected macrophages activated MAIT cells in a cytokine-dependent manner involving an IFNα-dependent early phase and an IL-18-induced later phase. Therefore, altered MAIT cell phenotypes represent valuable biomarkers of disease severity and their therapeutic manipulation might prevent the inflammatory phase involved in COVID-19 aggravation.
Document type :
Journal articles
Complete list of metadata

https://www.hal.inserm.fr/inserm-03035859
Contributor : Agnès Lehuen Connect in order to contact the contributor
Submitted on : Wednesday, December 2, 2020 - 1:32:55 PM
Last modification on : Tuesday, October 19, 2021 - 11:40:12 AM

Links full text

Identifiers

Citation

Héloïse Flament, Matthieu Rouland, Lucie Beaudoin, Amine Toubal, Léo Bertrand, et al.. Outcome of SARS-CoV-2 infection linked to MAIT cell activation and cytotoxicity: evidence for an IL-18 dependent mechanism. medRxiv : the preprint server for health sciences, [Cold Spring Harbor, NY] : Cold Spring Harbor Laboratory, [2019]-, 2020, Online ahead of print. ⟨10.1101/2020.08.31.20185082⟩. ⟨inserm-03035859⟩

Share

Metrics

Record views

117