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Targeted therapies in melanoma beyond BRAF : targeting NRAS-mutated and KIT-mutated melanoma

Abstract : Purpose of review: Melanoma treatment have been revolutionized since 2010 by the development of immune checkpoint inhibitors, and, for BRAF-mutated melanoma, targeted therapies based on BRAF and MEK inhibitors, which is a model of effective targeted therapy in cancer. However, patients with BRAF wild type cannot benefit for such treatments. In this review, we will focus on the current clinical development of targeted therapies beyond BRAF, in NRAS-mutated and KIT-altered melanoma. Recent findings: In NRAS-mutated melanoma, targeted therapies based on MEK inhibition are being developed as monotherapy or in combination with MAPK, PI3K or CDK4/6 inhibitor. Targeted therapies of KIT-altered melanoma patients is based in KIT inhibitor (mostly imatinib, nilotinib), although for both melanoma subtypes, results are for now disappointing as compared with BRAF and MEK inhibitors in BRAF-mutated melanoma. Summary: Combined therapeutic targeted strategies are awaited in NRAS-mutated and KIT-altered melanoma and could provide additional benefit.
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https://www.hal.inserm.fr/inserm-03033443
Contributor : Nicolas Dumaz Connect in order to contact the contributor
Submitted on : Tuesday, December 1, 2020 - 1:13:21 PM
Last modification on : Tuesday, September 28, 2021 - 5:15:45 PM

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Julie Delyon, Céleste Lebbe, Nicolas Dumaz. Targeted therapies in melanoma beyond BRAF : targeting NRAS-mutated and KIT-mutated melanoma. Current Opinion in Oncology, Lippincott, Williams & Wilkins, 2020, 32 (2), pp.79-84. ⟨10.1097/CCO.0000000000000606⟩. ⟨inserm-03033443⟩

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