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Photocontrol of Endogenous Glycine Receptors In Vivo

Alexandre M.J. Gomila 1, 2 Karin Rustler 3 Galyna Maleeva 2, 1, 4 Alba Nin-Hill 5, 6 Daniel Wutz 3 Antoni Bautista-Barrufet 1, 2 Xavier Rovira 1, 2 Miquel Bosch 1, 2 Elvira Mukhametova 4, 7 Elena Petukhova 8 Daria Ponomareva 8 Marat Mukhamedyarov 8 Franck Peiretti 9 Mercedes Alfonso-Prieto 10, 11 Carme Rovira 12, 13 Burkhard König 3 Piotr Bregestovski 4, 8 Pau Gorostiza 1, 2, 13
1 IBEC - Institute for Bioengineering of Catalonia [Barcelona]
2 BIST - Barcelona Institute of Science and Technology
3 University of Regensburg
4 INS - Institut de Neurosciences des Systèmes
5 Institut de Química Teòrica i Computacional (IQTCUB)
6 University of Barcelona
7 KFU - Kazan Federal University
8 KPFU - Kazan State University
9 C2VN - Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research
10 INM-1 - Institute of Neuroscience and Medicine [Jülich]
11 Heinrich-Heine-Universität Düsseldorf [Düsseldorf]
12 Universitat de Barcelona and the Intitut de Recerca en Química Teòrica i Computacional (IQTCUB)
13 ICREA - Institució Catalana de Recerca i Estudis Avançats
Abstract : Glycine receptors (GlyRs) are indispensable for maintaining excitatory/inhibitory balance in neuronal circuits that control reflexes and rhythmic motor behaviors. Here we have developed Glyght, a GlyR ligand controlled with light. It is selective over other Cys-loop receptors, is active in vivo, and displays an allosteric mechanism of action. The photomanipulation of glycinergic neurotransmission opens new avenues to understanding inhibitory circuits in intact animals and to developing drug-based phototherapies.
Keywords : CNS glycine receptors inhibitory neurotransmission in vivo optopharmacology photopharmacology photoswitch.
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Journal articles
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https://www.hal.inserm.fr/inserm-03032018
Contributor : Franck Peiretti <>
Submitted on : Monday, November 30, 2020 - 5:09:00 PM
Last modification on : Thursday, January 28, 2021 - 3:02:12 AM

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Alexandre M.J. Gomila, Karin Rustler, Galyna Maleeva, Alba Nin-Hill, Daniel Wutz, et al.. Photocontrol of Endogenous Glycine Receptors In Vivo. Cell Chemical Biology, Cell Press, 2020, 27 (11), pp.1425-1433.e7. ⟨10.1016/j.chembiol.2020.08.005⟩. ⟨inserm-03032018⟩

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