A radiomics pipeline dedicated to Breast MRI: validation on a multi-scanner phantom study - Archive ouverte HAL Access content directly
Journal Articles Magnetic Resonance Materials in Physics, Biology and Medicine Year : 2020

A radiomics pipeline dedicated to Breast MRI: validation on a multi-scanner phantom study

(1, 2) , (1) , (3, 1, 4) , (1) , (1) , (1) , (1, 4) , (1)
1
2
3
4

Abstract

Object: Quantitative analysis in MRI is challenging due to variabilities in intensity distributions across patients, acquisitions and scanners and suffers from bias field inhomogeneity. Radiomic studies are impacted by these effects that affect radiomic feature values. This paper describes a dedicated pipeline to increase reproducibility in breast MRI radiomic studies. Materials and Methods: T1, T2, and T1-DCE MR images of two breast phantoms were acquired using two scanners and three dual breast coils. Images were retrospectively corrected for bias field inhomogeneity and further normalised using Z-score or histogram matching. Extracted radiomic features were harmonised between coils by the ComBat method. The whole pipeline was assessed qualitatively and quantitatively using statistical comparisons on two series of radiomic feature values computed in the gel mimicking the normal breast tissue or in dense lesions. Results: Intra and inter-acquisition variabilities were strongly reduced by the standardisation pipeline. Harmonisation by ComBat lowered the percentage of radiomic features significantly different between the three coils from 87% after bias field correction and MR normalisation to 3% in the gel, while preserving or improving performance of lesion classification in the phantoms. Discussion: A dedicated standardisation pipeline was developed to reduce variabilities in breast MRI, which paves the way for robust multi-scanner radiomic studies but needs to be assessed on patient data.
Fichier principal
Vignette du fichier
AuthorAcceptedManuscript.pdf (3.08 Mo) Télécharger le fichier
Origin : Files produced by the author(s)

Dates and versions

inserm-03029480 , version 1 (28-11-2020)

Identifiers

Cite

Marie-Judith Saint Martin, Fanny Orlhac, Pia Akl, Fahad Khalid, Christophe Nioche, et al.. A radiomics pipeline dedicated to Breast MRI: validation on a multi-scanner phantom study. Magnetic Resonance Materials in Physics, Biology and Medicine, 2020, Online ahead of print. ⟨10.1007/s10334-020-00892-y⟩. ⟨inserm-03029480⟩
82 View
208 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More