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Drugs That Modify Cholesterol Metabolism Alter the p38/JNK-Mediated Targeted and Nontargeted Response to Alpha and Auger Radioimmunotherapy

Riad Ladjohounlou 1 Catherine Lozza 1, 2 Alexandre Pichard 1 Julie Constanzo 3 Jihad Karam 3 Pierre Le Fur 1 Emmanuel Deshayes 1 Vincent Boudousq 4 Salomé Paillas 1 Muriel Busson 1 Marion Le Blay 1 Marta Jarlier 1 Sara Marcatili 5 Manuel Bardiès 5 Frank Bruchertseifer 6, 7 Alfred Morgenstern 6, 7 Julien Torgue 8 Isabelle Navarro-Teulon 1 Jean-Pierre Pouget 1 
1 IRCM - U1194 Inserm - UM - Institut de Recherche en Cancérologie de Montpellier
2 PhyMedExp - Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046]
3 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
4 CHU Nîmes - Centre Hospitalier Universitaire de Nîmes
5 CRCT - Centre de Recherches en Cancérologie de Toulouse
6 Directorate for Nuclear Safety and Security [Karlsruhe, Germany]
7 JRC - European Commission - Joint Research Centre [Karlsruhe]
8 ORANO Med, Plano, Texas.
Abstract : For the development of new anticancer therapeutic radiopharmaceuticals, including alpha particle emitters, it is important to determine the contribution of targeted effects in irradiated cells, and also of nontargeted effects in nonirradiated neighboring cells, because they may affect the therapeutic efficacy and contribute to side effects.
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INSERM | CNRS | FNCLCC | VALDAURELLE | BS | UNIV-MONTPELLIER | IRCM | UNIV-UT3 | UT3-TOULOUSEINP

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Riad Ladjohounlou, Catherine Lozza, Alexandre Pichard, Julie Constanzo, Jihad Karam, et al.. Drugs That Modify Cholesterol Metabolism Alter the p38/JNK-Mediated Targeted and Nontargeted Response to Alpha and Auger Radioimmunotherapy. Clinical Cancer Research, American Association for Cancer Research, 2019, 25 (15), pp.4775-4790. ⟨10.1158/1078-0432.CCR-18-3295⟩. ⟨hal-02279598v2⟩

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