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Towards a Large-Scale Assessment of the Relationship Between Biological and Chronological Aging: The Inspire Mouse Cohort

Yohan Santin 1 Sébastien Lopez 2 Isabelle Ader 3 Sandrine Andrieu 4 Nicolas Blanchard 5 Audrey Carrière 3 Louis Casteilla 3 Béatrice Cousin 3 Noelie Davezac 2 Philipe Barreto de Souto 4 Cédric Dray 1 Nicolas Fazilleau 5 Daniel Gonzalez-Dunia 5 Pierre Gourdy 1 Sophie Guyonnet 4 Nabila Jabrane-Ferrat 5 Oksana Kunduzova 6 Frank Lezoualc'H 1 Roland Liblau 5 Laurent O. Martinez 7 Cedric Moro 1 Pierre Payoux 8 Luc Pénicaud 3 Valérie Planat-Benard 3 Claire Rampon 2 Yves Rolland 4 Joost-Peter Schanstra 1 Felipe Sierra 9 Philippe Valet 1 Audrey Varin 3 Nathalie Vergnolle 10 Bruno Vellas 4 José Viña 11 Bruno P. Guiard 2 Angelo Parini 1
1 I2MC - Institut des Maladies Métaboliques et Cardiovasculaires
2 CRCA - Centre de Recherches sur la Cognition Animale
3 STROMALab
4 Gérontopôle
5 CPTP - Centre de Physiopathologie Toulouse Purpan ex IFR 30 et IFR 150
6 I2MR - Institut de médecine moléculaire de Rangueil
7 INSERM - Institut National de la Santé et de la Recherche Médicale
8 ToNIC - Toulouse Neuro Imaging Center
9 NIA - National Institute on Aging [Bethesda, USA]
10 IRSD - Institut de Recherche en Santé Digestive
11 UPV - Universitat Politecnica de Valencia
Abstract : Aging is the major risk factor for the development of chronic diseases. After decades of research focused on extending lifespan, current efforts seek primarily to promote healthy aging. Recent advances suggest that biological processes linked to aging are more reliable than chronological age to account for an individual's functional status, i.e. frail or robust. It is becoming increasingly apparent that biological aging may be detectable as a progressive loss of resilience much earlier than the appearance of clinical signs of frailty. In this context, the INSPIRE program was built to identify the mechanisms of accelerated aging and the early biological signs predicting frailty and pathological aging. To address this issue, we designed a cohort of outbred SWISS mice (1576 male and female mice) in which we will continuously monitor spontaneous and voluntary physical activity from 6 to 24 months of age under either normal or high fat/high sucrose diet. At different age points (6, 12, 18, 24 months), multiorgan functional phenotyping will be carried out to identify early signs of organ dysfunction and generate a large biological fluids/feces/organs biobank (100,000 samples). A comprehensive correlation between functional and biological phenotypes will be assessed to determine: 1) the early signs of biological aging and their relationship with chronological age; 2) the role of dietary and exercise interventions on accelerating or decelerating the rate of biological aging; and 3) novel targets for the promotion of healthy aging. All the functional and omics data, as well as the biobank generated in the framework of the INSPIRE cohort will be available to the aging scientific community. The present article describes the scientific background and the strategies employed for the design of the INSPIRE Mouse cohort.
Keywords : INSPIRE program biological aging mouse cohort frailty biomarkers
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https://www.hal.inserm.fr/inserm-03019973
Contributor : Yohan Santin <>
Submitted on : Monday, November 23, 2020 - 4:07:34 PM
Last modification on : Wednesday, January 6, 2021 - 1:56:03 PM

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UNIV-TLSE3 | CRCA | UNIV-TLSE2 | CNRS | INRAE

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Yohan Santin, Sébastien Lopez, Isabelle Ader, Sandrine Andrieu, Nicolas Blanchard, et al.. Towards a Large-Scale Assessment of the Relationship Between Biological and Chronological Aging: The Inspire Mouse Cohort. The Journal of Frailty & Aging, Springer, In press, Online ahead of print. ⟨10.14283/jfa.2020.43⟩. ⟨inserm-03019973⟩

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