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Journal articles
Dysregulated lipid metabolism links NAFLD to cardiovascular disease
Abstract : Background
Non-alcoholic fatty liver disease (NAFLD) is rapidly becoming a global health problem. Cardiovascular diseases (CVD) are the most common cause of mortality in NAFLD patients. NAFLD and CVD share several common risk factors including obesity, insulin resistance, and type 2 diabetes (T2D). Atherogenic dyslipidemia, characterized by plasma hypertriglyceridemia, increased small dense low-density lipoprotein (LDL) particles, and decreased high-density lipoprotein cholesterol (HDL-C) levels, is often observed in NAFLD patients.
Scope of review
In this review, we highlight recent epidemiological studies evaluating the link between NAFLD and CVD risk. We further focus on recent mechanistic insights into the links between NAFLD and altered lipoprotein metabolism. We also discuss current therapeutic strategies for NAFLD and their potential impact on NAFLD-associated CVD risk.
Major conclusions
Alterations in hepatic lipid and lipoprotein metabolism are major contributing factors to the increased CVD risk in NAFLD patients, and many promising NASH therapies in development also improve dyslipidemia in clinical trials.
Cited literature [191 references]
https://www.hal.inserm.fr/inserm-03014459
Contributor : Marie-Hélène Derudas <>
Submitted on : Thursday, November 19, 2020 - 2:13:23 PM
Last modification on : Thursday, July 1, 2021 - 3:47:28 PM
Long-term archiving on: : Saturday, February 20, 2021 - 7:24:38 PM
Contributor : Marie-Hélène Derudas <>
Submitted on : Thursday, November 19, 2020 - 2:13:23 PM
Last modification on : Thursday, July 1, 2021 - 3:47:28 PM
Long-term archiving on: : Saturday, February 20, 2021 - 7:24:38 PM
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Mol Metab Deprince A.pdf
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Distributed under a Creative Commons Attribution - NonCommercial - NoDerivatives 4.0 International License