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Assessing the consequences of environmental exposures on the expression of the human receptor and proteases involved in SARS-CoV-2 cell-entry

Abstract : The role of environmental condition on the infection by the novel pathogenic SARS-CoV-2 virus remains uncertain. In here, exploiting a large panel of publicly available genome-wide data, we investigated whether the human receptor ACE2 and human proteases TMPRSS2, FURIN and CATHEPSINs (B, L and V), which are involved in SARS-CoV-2 cell entry, are transcriptionally regulated by environmental cues. We report that more than 50 chemicals modulate the expression of ACE2 or human proteases important for SARS-CoV-2 cell entry. We further demonstrate that transcription factor AhR, which is commonly activated by pollutants, binds to the promoter of TMPRSS2 and enhancers and/or promoters of Cathepsin B, L and V encoding genes. Our exploratory study documents an influence of environmental exposures on the expression of genes involved in SARS-CoV-2 cell entry. These results could be conceptually and medically relevant to our understanding of the COVID-19 disease, and should be further explored in laboratory and epidemiologic studies.
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https://www.hal.inserm.fr/inserm-03009801
Contributor : Benoit Miotto <>
Submitted on : Tuesday, November 17, 2020 - 2:17:06 PM
Last modification on : Wednesday, June 2, 2021 - 4:26:07 PM

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Manon Watzky, Maud de Dieuleveult, Anne Letessier, Claude Saint-Ruf, Benoit Miotto. Assessing the consequences of environmental exposures on the expression of the human receptor and proteases involved in SARS-CoV-2 cell-entry. Environmental Research, Elsevier, 2020, pp.110317. ⟨10.1016/j.envres.2020.110317⟩. ⟨inserm-03009801⟩

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