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Leptin down-regulates KCC2 activity and controls chloride homeostasis in the neonatal rat hippocampus

Abstract : The canonical physiological role of leptin is to regulate hunger and satiety acting on specific hypothalamic nuclei. Beyond this key metabolic function; leptin also regulates many aspects of development and functioning of neuronal hippocampal networks throughout life. Here we show that leptin controls chloride homeostasis in the developing rat hippocampus in vitro. The effect of leptin relies on the down-regulation of the potassium/chloride extruder KCC2 activity and is present during a restricted period of postnatal development. This study confirms and extends the role of leptin in the ontogenesis of functional GABAergic inhibition and helps understanding how abnormal levels of leptin may contribute to neurological disorders.
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https://www.hal.inserm.fr/inserm-03007127
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Submitted on : Monday, November 16, 2020 - 11:28:32 AM
Last modification on : Tuesday, November 17, 2020 - 3:12:39 AM
Long-term archiving on: : Wednesday, February 17, 2021 - 6:47:11 PM

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Camille Dumon, Yasmine Belaidouni, Diabe Diabira, Suzanne Appleyard, Gary Wayman, et al.. Leptin down-regulates KCC2 activity and controls chloride homeostasis in the neonatal rat hippocampus. Molecular Brain, BioMed Central, 2020, 13 (1), pp.151. ⟨10.1186/s13041-020-00689-z⟩. ⟨inserm-03007127⟩

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