M. Fani, H. R. Maecke, and S. M. Okarvi, Radiolabeled Peptides: Valuable Tools for the Detection and Treatment of Cancer, Theranostics, vol.2, issue.5, pp.481-501, 2012.

G. Walsh and . Biopharmaceutical, Biopharmaceutical benchmarks 2018, Nature Biotechnology, vol.36, issue.12, pp.1136-1145, 2018.

B. Leader, Q. J. Baca, and D. E. Golan, Protein therapeutics: a summary and pharmacological classification, Nature Reviews Drug Discovery, vol.7, issue.1, pp.21-39, 2008.

S. Jarchi, F. Ataei, and S. Hosseinkhani, Mutation of conserved residues K329 and R330 on the surface of firefly luciferase: Effect on proteolytic degradation, International Journal of Biological Macromolecules, vol.115, pp.324-330, 2018.

J. R. Kintzing, M. V. Filsinger-interrante, and J. R. Cochran, Emerging Strategies for Developing Next-Generation Protein Therapeutics for Cancer Treatment, Trends in Pharmacological Sciences, vol.37, issue.12, pp.993-1008, 2016.

N. Kaur, A. Narang, and A. K. Bansal, Use of biorelevant dissolution and PBPK modeling to predict oral drug absorption, European Journal of Pharmaceutics and Biopharmaceutics, vol.129, pp.222-246, 2018.

M. Minekus, A standardised static in vitro digestion method suitable for food: an international consensus, Food Funct, vol.5, pp.1113-1124, 2014.
URL : https://hal.archives-ouvertes.fr/hal-01195466

R. Korte, J. Bräcker, and J. Brockmeyer, Gastrointestinal digestion of hazelnut allergens on molecular level: Elucidation of degradation kinetics and resistant immunoactive peptides using mass spectrometry, Molecular Nutrition & Food Research, vol.61, issue.10, p.1700130, 2017.

K. R. Roesler and A. G. Rao, Rapid Gastric Fluid Digestion and Biochemical Characterization of Engineered Proteins Enriched in Essential Amino Acids, Journal of Agricultural and Food Chemistry, vol.49, issue.7, pp.3443-3451, 2001.

U. H. Weidle, F. Birzele, and G. Tiefenthaler, Potential of Protein-based Anti-metastatic Therapy with Serpins and Inter ?-Trypsin Inhibitors, Cancer Genomics - Proteomics, vol.15, issue.4, pp.225-238, 2018.

R. Simeon and Z. Chen, In vitro-engineered non-antibody protein therapeutics, Protein & Cell, vol.9, issue.1, pp.3-14, 2017.

K. ?krlec, B. ?trukelj, and A. Berlec, Non-immunoglobulin scaffolds: a focus on their targets, Trends in Biotechnology, vol.33, issue.7, pp.408-418, 2015.

M. Gebauer and A. Skerra, Engineering of binding functions into proteins, Current Opinion in Biotechnology, vol.60, pp.230-241, 2019.

B. Mouratou, F. Schaeffer, I. Guilvout, D. Tello-manigne, A. P. Pugsley et al., Remodeling a DNA-binding protein as a specific in vivo inhibitor of bacterial secretin PulD, Proceedings of the National Academy of Sciences, vol.104, issue.46, pp.17983-17988, 2007.
URL : https://hal.archives-ouvertes.fr/hal-00412884

P. Vukojicic, G. Béhar, M. H. Tawara, M. Fernandez-villamarin, F. Pecorari et al., Multivalent Affidendrons with High Affinity and Specificity toward Staphylococcus aureus as Versatile Tools for Modulating Multicellular Behaviors, ACS Applied Materials & Interfaces, vol.11, issue.24, pp.21391-21398, 2019.
URL : https://hal.archives-ouvertes.fr/inserm-02167902

M. Goux, Nanofitin as a New Molecular-Imaging Agent for the Diagnosis of Epidermal Growth Factor Receptor Over-Expressing Tumors, Bioconjug. Chem, vol.28, pp.2361-2371

G. Béhar, A. Renodon?cornière, S. Kambarev, P. Vukojicic, N. Caroff et al., Whole?bacterium ribosome display selection for isolation of highly specific anti? Staphyloccocus aureus Affitins for detection? and capture?based biomedical applications, Biotechnology and Bioengineering, vol.116, issue.8, pp.1844-1855, 2019.

M. Cinier, M. Petit, M. N. Williams, R. M. Fabre, F. Pecorari et al., Bisphosphonate Adaptors for Specific Protein Binding on Zirconium Phosphonate-based Microarrays, Bioconjugate Chemistry, vol.20, issue.12, pp.2270-2277, 2009.

F. F. Miranda, E. Brient-litzler, N. Zidane, F. Pecorari, and H. Bedouelle, Reagentless fluorescent biosensors from artificial families of antigen binding proteins, Biosensors and Bioelectronics, vol.26, issue.10, pp.4184-4190, 2011.

C. S. Fernandes, R. Dos-santos, S. Ottengy, A. C. Viecinski, G. Béhar et al., Affitins for protein purification by affinity magnetic fishing, Journal of Chromatography A, vol.1457, pp.50-58, 2016.
URL : https://hal.archives-ouvertes.fr/inserm-01342446

G. Béhar, A. Renodon-cornière, B. Mouratou, and F. Pecorari, Affitins as robust tailored reagents for affinity chromatography purification of antibodies and non-immunoglobulin proteins, Journal of Chromatography A, vol.1441, pp.44-51, 2016.

F. Pecorari and P. Alzari, Ob-Fold Used as Scaffold for Engineering New Specific Binders, 2008.

A. Correa, S. Pacheco, A. E. Mechaly, G. Obal, G. Béhar et al., Potent and Specific Inhibition of Glycosidases by Small Artificial Binding Proteins (Affitins), PLoS ONE, vol.9, issue.5, p.e97438, 2014.

E. Jantratid, N. Janssen, C. Reppas, and J. B. Dressman, Dissolution Media Simulating Conditions in the Proximal Human Gastrointestinal Tract: An Update, Pharmaceutical Research, vol.25, issue.7, pp.1663-1676, 2008.

. Maeng, . Yoon, . Chun, . Kim, . Jang et al., Metabolic Stability of D-Allulose in Biorelevant Media and Hepatocytes: Comparison with Fructose and Erythritol, Foods, vol.8, issue.10, p.448, 2019.

W. Liu, A. Ye, W. Liu, C. Liu, J. Han et al., Behaviour of liposomes loaded with bovine serum albumin during in vitro digestion, Food Chemistry, vol.175, pp.16-24, 2015.

M. J. Betts and R. B. Russell, Amino Acid Properties and Consequences of Substitutions, Bioinformatics for Geneticists, pp.289-316

Y. Hamuro, S. J. Coales, K. S. Molnar, S. J. Tuske, and J. A. Morrow, Specificity of immobilized porcine pepsin in H/D exchange compatible conditions, Rapid Communications in Mass Spectrometry, vol.22, issue.7, pp.1041-1046, 2008.

J. Ahn, M. Cao, Y. Q. Yu, and J. R. Engen, Accessing the reproducibility and specificity of pepsin and other aspartic proteases, Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, vol.1834, issue.6, pp.1222-1229, 2013.

S. Pacheco, G. Behar, M. Maillasson, B. Mouratou, and F. Pecorari, Affinity transfer to the archaeal extremophilic Sac7d protein by insertion of a CDR, Protein Engineering Design and Selection, vol.27, issue.10, pp.431-438, 2014.

G. Behar, M. Bellinzoni, M. Maillasson, L. Paillard-laurance, P. M. Alzari et al., Tolerance of the archaeal Sac7d scaffold protein to alternative library designs: characterization of anti-immunoglobulin G Affitins, Protein Engineering Design and Selection, vol.26, issue.4, pp.267-275, 2013.

S. P. Edmondson and J. W. Shriver, [11] DNA-binding proteins Sac7d and Sso7d from Sulfolobus, Methods in Enzymology, vol.334, pp.129-145, 2001.

F. Catanzano, G. Graziano, P. Fusi, P. Tortora, and G. Barone, Differential Scanning Calorimetry Study of the Thermodynamic Stability of Some Mutants of Sso7d fromSulfolobus solfataricus?, Biochemistry, vol.37, issue.29, pp.10493-10498, 1998.

A. B. Ghisaidoobe and S. J. Chung, Intrinsic Tryptophan Fluorescence in the Detection and Analysis of Proteins: A Focus on Förster Resonance Energy Transfer Techniques, International Journal of Molecular Sciences, vol.15, issue.12, pp.22518-22538, 2014.

A. Micsonai, F. Wien, L. Kernya, Y. Lee, Y. Goto et al., Accurate secondary structure prediction and fold recognition for circular dichroism spectroscopy, Proceedings of the National Academy of Sciences, vol.112, issue.24, pp.E3095-E3103, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01485547

M. R. Arkin and J. A. Wells, Probing the importance of second sphere residues in an esterolytic antibody by phage display, Journal of Molecular Biology, vol.284, issue.4, pp.1083-1094, 1998.

V. Kalichuk, G. Béhar, A. Renodon-cornière, G. Danovski, G. Obal et al., The archaeal ?7 kDa DNA-binding? proteins: extended characterization of an old gifted family, Scientific Reports, vol.6, issue.1, p.37274, 2016.
URL : https://hal.archives-ouvertes.fr/inserm-01398571

G. Béhar, S. Pacheco, M. Maillasson, B. Mouratou, and F. Pecorari, Switching an anti-IgG binding site between archaeal extremophilic proteins results in Affitins with enhanced pH stability, Journal of Biotechnology, vol.192, pp.123-129, 2014.

C. Niu, P. Yang, H. Luo, H. Huang, Y. Wang et al., Erratum: Corrigendum: Engineering the residual side chains of HAP phytases to improve their pepsin resistance and catalytic efficiency, Scientific Reports, vol.7, issue.1, p.42133, 2017.

X. Chen, W. Li, P. Ji, Y. Zhao, C. Hua et al., Engineering the conserved and noncatalytic residues of a thermostable ?-1,4-endoglucanase to improve specific activity and thermostability, Scientific Reports, vol.8, issue.1, p.2954, 2018.

T. Tu, Y. Wang, H. Huang, Y. Wang, X. Jiang et al., Improving the thermostability and catalytic efficiency of glucose oxidase from Aspergillus niger by molecular evolution, Food Chemistry, vol.281, pp.163-170, 2019.

C. Camilloni, B. M. Sala, P. Sormanni, R. Porcari, A. Corazza et al., Rational design of mutations that change the aggregation rate of a protein while maintaining its native structure and stability, Scientific Reports, vol.6, issue.1, p.25559, 2016.

N. M. Ashraf, A. Krishnagopal, A. Hussain, D. Kastner, A. M. Sayed et al., Engineering of serine protease for improved thermostability and catalytic activity using rational design, International Journal of Biological Macromolecules, vol.126, pp.229-237, 2019.

A. Loussouarn, G. Béhar, F. Pecorari, M. Croyal, and A. Renodon-cornière, Characterization of Affitin proteolytic digestion in biorelevant media and improvement of their stabilities via protein engineering, Scientific Reports, vol.10, issue.1, 2020.
URL : https://hal.archives-ouvertes.fr/inserm-03007124

C. Han, W. Li, C. Hua, F. Sun, P. Bi et al., Enhancement of catalytic activity and thermostability of a thermostable cellobiohydrolase from Chaetomium thermophilum by site-directed mutagenesis, International Journal of Biological Macromolecules, vol.116, pp.691-697, 2018.

K. Otsuka, Y. Shono, and J. Dressman, Coupling biorelevant dissolution methods with physiologically based pharmacokinetic modelling to forecast in-vivo performance of solid oral dosage forms, Journal of Pharmacy and Pharmacology, vol.65, issue.7, pp.937-952, 2013.

M. Charpentier, M. Croyal, D. Carbonnelle, A. Fortun, L. Florenceau et al., IRES-dependent translation of the long non coding RNA meloe in melanoma cells produces the most immunogenic MELOE antigens, Oncotarget, vol.7, issue.37, pp.59704-59713, 2016.
URL : https://hal.archives-ouvertes.fr/inserm-01409602

M. Croyal, F. Fall, V. Ferchaud-roucher, M. Chétiveaux, Y. Zaïr et al., Multiplexed peptide analysis for kinetic measurements of major human apolipoproteins by LC/MS/MS, Journal of Lipid Research, vol.57, issue.3, pp.509-515, 2016.
URL : https://hal.archives-ouvertes.fr/hal-02429670