S. Yamashita, A. J. Shah, S. Mahida, J. Sellal, B. Berte et al., Body Surface Mapping to Guide Atrial Fibrillation Ablation, Arrhythmia & Electrophysiology Review, vol.4, issue.3, p.172, 2015.

D. Cappellen, France) for helpful discussions; DBS is supported by the National Institutes of Health Intramural Research Program and Laura Biguet for technical support

J. Ferlay, I. Soerjomataram, R. Dikshit, S. Eser, C. Mathers et al., Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012, International Journal of Cancer, vol.136, issue.5, pp.E359-E386, 2014.

L. Schistosomes, . Flukes, and . Helicobacter, IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, IARC Monogr Eval Carcinog Risks Hum, vol.61, pp.1-241, 1994.

M. R. Amieva, R. Vogelmann, A. Covacci, L. S. Tompkins, W. J. Nelson et al., Disruption of the Epithelial Apical-Junctional Complex by Helicobacter pylori CagA, Science, vol.300, issue.5624, pp.1430-1434, 2003.

J. Baud, C. Varon, S. Chabas, L. Chambonnier, F. Darfeuille et al., Helicobacter pylori Initiates a Mesenchymal Transition through ZEB1 in Gastric Epithelial Cells, PLoS ONE, vol.8, issue.4, p.e60315, 2013.

E. Bessède, C. Staedel, L. A. Acuña-amador, P. H. Nguyen, L. H. Chambonnier et al., Helicobacter pylori generates cells with cancer stem cell properties via epithelial?mesenchymal transition-like changes, Oncogene, vol.33, issue.32, pp.4123-4131, 2013.

E. Bessède, P. Dubus, F. Mégraud, and C. Varon, Helicobacter pylori infection and stem cells at the origin of gastric cancer, Oncogene, vol.34, issue.20, pp.2547-2555, 2014.

S. A. Mani, W. Guo, M. J. Liao, E. N. Eaton, A. Ayyanan et al., The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells, Cell, vol.133, issue.4, pp.704-715, 2008.

P. Lauren, THE TWO HISTOLOGICAL MAIN TYPES OF GASTRIC CARCINOMA: DIFFUSE AND SO-CALLED INTESTINAL-TYPE CARCINOMA, Acta Pathologica Microbiologica Scandinavica, vol.64, issue.1, pp.31-49, 1965.

K. Wang, S. T. Yuen, J. Xu, S. P. Lee, H. H. Yan et al., Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer, Nature Genetics, vol.46, issue.6, pp.573-582, 2014.

M. D. Brown and D. B. Sacks, IQGAP1 in cellular signaling: bridging the GAP, Trends in Cell Biology, vol.16, issue.5, pp.242-249, 2006.

J. Noritake, T. Watanabe, K. Sato, S. Wang, and K. Kaibuchi, IQGAP1: a key regulator of adhesion and migration, Journal of Cell Science, vol.118, issue.10, pp.2085-2092, 2005.

N. Sugimoto, I. Imoto, Y. Fukuda, N. Kurihara, S. Kuroda et al., IQGAP1, a negative regulator of cell-cell adhesion, is upregulated by gene amplification at 15q26 in gastric cancer cell lines HSC39 and 40A, Journal of Human Genetics, vol.46, issue.1, pp.21-25, 2001.

M. W. Briggs and D. B. Sacks, IQGAP proteins are integral components of cytoskeletal regulation, EMBO reports, vol.4, issue.6, pp.571-574, 2003.

L. Jadeski, J. M. Mataraza, H. W. Jeong, Z. Li, and D. B. Sacks, IQGAP1 Stimulates Proliferation and Enhances Tumorigenesis of Human Breast Epithelial Cells, Journal of Biological Chemistry, vol.283, issue.2, pp.1008-1017, 2007.

K. Nabeshima, Y. Shimao, T. Inoue, and M. Koono, Immunohistochemical analysis of IQGAP1 expression in human colorectal carcinomas: its overexpression in carcinomas and association with invasion fronts, Cancer Letters, vol.176, issue.1, pp.101-109, 2002.

A. Walch, S. Seidl, C. Hermannstädter, S. Rauser, J. Deplazes et al., Combined analysis of Rac1, IQGAP1, Tiam1 and E-cadherin expression in gastric cancer, Modern Pathology, vol.21, issue.5, pp.544-552, 2008.

H. Takemoto, Y. Doki, H. Shiozaki, H. Imamura, T. Utsunomiya et al., Localization of IQGAP1 is inversely correlated with intercellular adhesion mediated by e-cadherin in gastric cancers, International Journal of Cancer, vol.91, issue.6, pp.783-788, 2001.

S. Li, Q. Wang, A. Chakladar, R. T. Bronson, and A. Bernards, Gastric Hyperplasia in Mice Lacking the Putative Cdc42 Effector IQGAP1, Molecular and Cellular Biology, vol.20, issue.2, pp.697-701, 2000.

X. Cai, J. Carlson, C. Stoicov, H. Li, T. C. Wang et al., Helicobacter felis Eradication Restores Normal Architecture and Inhibits Gastric Cancer Progression in C57BL/6 Mice, Gastroenterology, vol.128, issue.7, pp.1937-1952, 2005.

C. Varon, P. Dubus, F. Mazurier, C. Asencio, L. Chambonnier et al., Helicobacter pylori Infection Recruits Bone Marrow?Derived Cells That Participate in Gastric Preneoplasia in Mice, Gastroenterology, vol.142, issue.2, pp.281-291, 2012.

B. Humar, V. Blair, A. Charlton, H. More, I. Martin et al., E-Cadherin Deficiency Initiates Gastric Signet-Ring Cell Carcinoma in Mice and Man, Cancer Research, vol.69, issue.5, pp.2050-2056, 2009.

M. A. Osman, G. S. Bloom, and E. A. Tagoe, Helicobacter pylori-induced alteration of epithelial cell signaling and polarity: A possible mechanism of gastric carcinoma etiology and disparity, Cytoskeleton, vol.70, issue.7, pp.349-359, 2013.

V. S. Conlin, S. B. Curtis, Y. Zhao, E. D. Moore, V. C. Smith et al., Helicobacter pylori Infection Targets Adherens Junction Regulatory Proteins and Results in Increased Rates of Migration in Human Gastric Epithelial Cells, Infection and Immunity, vol.72, issue.9, pp.5181-5192, 2004.

N. Ohnishi, H. Yuasa, S. Tanaka, H. Sawa, M. Miura et al., Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse, Proceedings of the National Academy of Sciences, vol.105, issue.3, pp.1003-1008, 2008.

A. T. Franco, E. Johnston, U. Krishna, Y. Yamaoka, D. A. Israel et al., Regulation of Gastric Carcinogenesis by Helicobacter pylori Virulence Factors, Cancer Research, vol.68, issue.2, pp.379-387, 2008.

P. Peek, R. M. , and J. , Regulation of gastric carcinogenesis by Helicobacter pylori virulence factors, Cancer Res, vol.68, pp.379-87, 2008.

N. Murata-kamiya, Y. Kurashima, Y. Teishikata, Y. Yamahashi, Y. Saito et al., Helicobacter pylori CagA interacts with E-cadherin and deregulates the ?-catenin signal that promotes intestinal transdifferentiation in gastric epithelial cells, Oncogene, vol.26, issue.32, pp.4617-4626, 2007.

Y. Saito, N. Murata-kamiya, T. Hirayama, Y. Ohba, and M. Hatakeyama, Conversion of Helicobacter pylori CagA from senescence inducer to oncogenic driver through polarity-dependent regulation of p21, Journal of Experimental Medicine, vol.207, issue.10, pp.2157-2174, 2010.

L. E. Morris, G. S. Bloom, H. F. Frierson, and S. M. Powell, Nucleotide variants within theIQGAP1 gene in diffuse-type gastric cancers, Genes, Chromosomes and Cancer, vol.42, issue.3, pp.280-286, 2005.