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Metformin can inhibit Helicobacter pylori growth

Abstract : Aim: Helicobacter pylori infection is a worldwide infection, its eradication rates with conventional therapies have fallen to unacceptable levels. In this context we were interested in metformin, to determine its effect on H. pylori growth. Materials & methods: Antimicrobial susceptibility tests and survival curves were performed in vitro and a H. pylori-infected mice model was used to determine metformin effect in vivo. Results: Helicobacter pylori survival and growth were decreased in presence of metformin. Furthermore, metformin-treated mice had significantly less bacteria in their stomach than the untreated mice. Conclusion: Our work is the first to demonstrate a direct antimicrobial effect of metformin on H. pylori, indicating that this molecule has not yet revealed its full potential.
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Contributor : Christine Varon Connect in order to contact the contributor
Submitted on : Friday, November 13, 2020 - 6:20:01 PM
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Sarah Courtois, Lucie Bénéjat, Julien Izotte, Francis Mégraud, Christine Varon, et al.. Metformin can inhibit Helicobacter pylori growth. Future Microbiology, Future Medicine, 2018, 13 (14), pp.1575-1583. ⟨10.2217/fmb-2018-0184⟩. ⟨inserm-03004859⟩



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