Skip to Main content Skip to Navigation
Journal articles

Helicobacter pylori eradication rates in Slovenia in the period from 2017 to 2019 – data from the European Registry on Helicobacter pylori Management (Hp-EuReg)

Abstract : Background: Helicobacter pylori (H pylori) is the most common chronic bacterial infection in the world, affecting over 50% of the world's population. H pylori is a grade I carcinogen, responsible for the development of 89% of non-cardia gastric cancers. In the present study, we analyzed the data for H pylori eradication treatments in Slovenia after the 3rd National recommendations were implemented. Patients and methods: Slovenia is part of the European Registry on H pylori Management (Hp-EuReg) since the study was launched in 2013. Data were collected at AEG-REDCap e-CRF from September 2017 to December 2019. H pylori eradication treatment was assessed by modified intention-to-treat (mITT) and per-protocol (PP) analyses. Results: Overall, 823 patients from 3 medical institutions were included. Effectiveness with first line 14-day triple therapy with a proton-pomp-inhibitor (PPI), clarithromycin 500 mg, amoxicillin 1000 mg, all BID, was 93% by mITT (714 patients). In patients allergic to penicillin, first line 14-day triple therapy with PPI-clarithromycin-metronidazole achieved 83% effectiveness by mITT (35 patients). Second-line 14-day triple therapy with a PPI-amoxicillin-levofloxacin achieved 89% mITT eradication rate (51 patients). Second-line therapy with the 10-day three-in-one single capsule containing bismuth-tetracycline- metronidazole achieved optimal effectiveness (100% mITT) in 10 patients ( p=0.02). Conclusions: Slovenia is a country with < 15% H pylori resistance to clarithromycin. Triple therapy with a PPI plus two antibiotics during 14 days reported optimal effectiveness (over 90%). Ten-day quadruple bismuth second-line therapy had better results than 14-day triple therapy with levofloxacin).
Document type :
Journal articles
Complete list of metadata

https://www.hal.inserm.fr/inserm-02999845
Contributor : Francis Megraud Connect in order to contact the contributor
Submitted on : Wednesday, November 11, 2020 - 10:40:07 AM
Last modification on : Wednesday, November 11, 2020 - 2:16:02 PM

Identifiers

Collections

Citation

Bojan Tepes, Natasa Brglez Jurecic, Katja Tepes, Marta Espada Sanchez, Olga Perez Nyssen, et al.. Helicobacter pylori eradication rates in Slovenia in the period from 2017 to 2019 – data from the European Registry on Helicobacter pylori Management (Hp-EuReg). Digestive Diseases, Karger, 2020, Online ahead of print. ⟨10.1159/000512506⟩. ⟨inserm-02999845⟩

Share

Metrics

Record views

86