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A standardised model for stool banking for faecal microbiota transplantation: a consensus report from a multidisciplinary UEG working group

Josbert Keller 1, 2 Rogier Ooijevaar 2, 3 Christian Hvas 4 Elisabeth Terveer 2 Simone Lieberknecht 5 Christoph Högenauer 6 Perttu Arkkila 7 Harry Sokol 8, 9, 10 Oleksiy Gridnyev 2 Francis Mégraud 11 Patrizia Kump 6 Radislav Nakov 12 Simon Goldenberg 13, 14 Reetta Satokari 7 Sergiy Tkatch 15 Maurizio Sanguinetti 16 Giovanni Cammarota 17 Andrey Dorofeev 18 Olena Gubska 19 Gianluca Ianiro 17 Eero Mattila 7 Ramesh Arasaradnam 20 Shiv Sarin 21 Ajit Sood 22 Lorenza Putignani 23 Laurent Alric 24, 25 Simon Md Baunwall 26 Juozas Kupcinskas 27 Alexander Link 28 Abraham Goorhuis 2, 26 Hein Verspaget 2, 29 Cyriel Ponsioen 26 Georgina Hold 30 Herbert Tilg 31 Zain Kassam 32 Ed Kuijper 2, 4, 33 Antonio Gasbarrini 34 Chris Jj Mulder 2, 26 Horace Rt Williams 35 Maria Jgt Vehreschild 2, 33, 36, 37
1 HMC - Haaglanden Medical Center [La Haye, Pays-Bas]
2 Leiden University Medical Center (LUMC)
3 UvA - University of Amsterdam [Amsterdam]
4 Aarhus University Hospital
5 Frankfurt University Hospital
6 Medical University Graz
7 University of Helsinki
8 CHU Saint-Antoine [AP-HP]
9 MICALIS - MICrobiologie de l'ALImentation au Service de la Santé
10 GFTF - French Group of Fecal Microbiota Transplantation [Paris]
11 Physiopathologie du cancer du foie
12 Tsaritsa Yoanna University Hospital [Sofia]
13 King‘s College London
14 Guy's and St Thomas NHS Foundation Trust [London]
15 Ukranian Scientific and Practical Center of Endocrine Surgery [Kyiv]
16 Fondazione Policlinico Universitario Agostino Gemelli IRCCS [Rome]
17 Fondazione Policlinico Universitario Agostino Gemelli [Rome]
18 National Medical Academy of Postgraduate Education n.a. P.L. Shupic [Kiev]
19 Bogomolets national medical university
20 UHCW - University Hospital Coventry Warwickshire
21 Institute of Liver and Biliary Sciences [New Delhi]
22 Dayanand Medical College and Hospital [Ludhiana]
23 IRCCS Ospedale Pediatrico Bambino Gesù [Roma]
24 UT3 - Université Toulouse III - Paul Sabatier
25 CHU Toulouse [Toulouse]
26 VU University Medical Center [Amsterdam]
27 Lithuanian University of health Sciences [Kaunas]
28 OVGU - Otto-von-Guericke University [Magdeburg]
29 Leids Universitair Medisch Centrum [Leiden]
30 UNSW - University of New South Wales [Sydney]
31 IMU - Innsbruck Medical University [Austria]
32 Finch Therapeutics Group [Somerville, MA, États-Unis]
33 ESGHAMI - ESCMID Study Group for Host and Microbiota Interaction [Basel]
34 Fondazione Policlinico Universitario Agostino Gemelli IRCCS
35 Imperial College London
36 University of Cologne
37 DZIF - German Centre for Infection Research
Abstract : Background: Fecal microbiota transplantation is an emerging therapeutic option, particularly for the treatment of recurrent Clostridioides difficile infection. Stool banks that organise recruitment and screening of feces donors are being embedded within the regulatory frameworks described in the European Union Tissue and Cells Directive and the technical guide to the quality and safety of tissue and cells for human application, published by the European Council. Objective: Several European and international consensus statements concerning fecal microbiota transplantation have been issued. While these documents provide overall guidance, we aim to provide a detailed description of all processes that relate to the collection, handling and clinical application of human donor stool in this document. Methods: Collaborative subgroups of experts on stool banking drafted concepts for all domains pertaining to stool banking. During a working group meeting in the United European Gastroenterology Week 2019 in Barcelona, these concepts were discussed and finalised to be included in our overall guidance document about fecal microbiota transplantation. Results: A guidance document for all domains pertaining to stool banking was created. This document includes standard operating manuals for several processes involved with stool banking, such as handling of donor material, storage and donor screening. Conclusion: The implementation of fecal microbiota transplantation by stool banks in concordance with our guidance document will enable quality assurance and guarantee the availability of donor feces preparations for patients.
Keywords : Clostridioides difficile Fecal microbiota transplantation legislation stool bank.
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Journal articles
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https://www.hal.inserm.fr/inserm-02996890
Contributor : Francis Megraud Connect in order to contact the contributor
Submitted on : Monday, November 9, 2020 - 6:45:08 PM
Last modification on : Saturday, July 3, 2021 - 12:29:05 AM

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INSERM | UNIV-TLSE3 | AGROPARISTECH | INRAE | SORBONNE-UNIVERSITE | SU-TI | GS-BIOSPHERA | GS-LIFE-SCIENCES-HEALTH | GS-HEALTH-DRUG-SCIENCES

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Josbert Keller, Rogier Ooijevaar, Christian Hvas, Elisabeth Terveer, Simone Lieberknecht, et al.. A standardised model for stool banking for faecal microbiota transplantation: a consensus report from a multidisciplinary UEG working group. United European Gastroenterology Journal, SAGE Publications, 2020, pp.2050640620967898. ⟨10.1177/2050640620967898⟩. ⟨inserm-02996890⟩

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