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A standardised model for stool banking for faecal microbiota transplantation: a consensus report from a multidisciplinary UEG working group

Josbert J Keller 1, 2 Rogier E Ooijevaar 2, 3 Christian L Hvas 4 Elisabeth M Terveer 2 Simone C Lieberknecht 5 Christoph Högenauer 6 Perttu Arkkila 7 Harry Sokol 8, 9, 10 Oleksiy Gridnyev 2 Francis Mégraud 11 Patrizia K Kump 6 Radislav Nakov 12 Simon D Goldenberg 13, 14 Reetta Satokari 7 Sergiy Tkatch 15 Maurizio Sanguinetti 16 Giovanni Cammarota 16 Andrey Dorofeev 17 Olena Gubska 18 Gianluca Ianiro 16 Eero Mattila 7 Ramesh P Arasaradnam 19 Shiv K Sarin 20 Ajit Sood 21 Lorenza Putignani 22 Laurent Alric 23, 24 Simon Md Baunwall 25 Juozas Kupcinskas 26 Alexander Link 27 Abraham G Goorhuis 2, 25 Hein W Verspaget 2, 28 Cyriel Ponsioen 25 Georgina L Hold 29 Herbert Tilg 30 Zain Kassam 31 Ed J Kuijper 2, 4, 32 Antonio Gasbarrini 16 Chris Jj Mulder 2, 25 Horace Rt Williams 33 Maria Jgt Vehreschild 2, 32, 34, 35 
Abstract : Background: Fecal microbiota transplantation is an emerging therapeutic option, particularly for the treatment of recurrent Clostridioides difficile infection. Stool banks that organise recruitment and screening of feces donors are being embedded within the regulatory frameworks described in the European Union Tissue and Cells Directive and the technical guide to the quality and safety of tissue and cells for human application, published by the European Council. Objective: Several European and international consensus statements concerning fecal microbiota transplantation have been issued. While these documents provide overall guidance, we aim to provide a detailed description of all processes that relate to the collection, handling and clinical application of human donor stool in this document. Methods: Collaborative subgroups of experts on stool banking drafted concepts for all domains pertaining to stool banking. During a working group meeting in the United European Gastroenterology Week 2019 in Barcelona, these concepts were discussed and finalised to be included in our overall guidance document about fecal microbiota transplantation. Results: A guidance document for all domains pertaining to stool banking was created. This document includes standard operating manuals for several processes involved with stool banking, such as handling of donor material, storage and donor screening. Conclusion: The implementation of fecal microbiota transplantation by stool banks in concordance with our guidance document will enable quality assurance and guarantee the availability of donor feces preparations for patients.
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Submitted on : Monday, November 9, 2020 - 6:45:08 PM
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Josbert J Keller, Rogier E Ooijevaar, Christian L Hvas, Elisabeth M Terveer, Simone C Lieberknecht, et al.. A standardised model for stool banking for faecal microbiota transplantation: a consensus report from a multidisciplinary UEG working group. United European Gastroenterology Journal, SAGE Publications, 2020, pp.2050640620967898. ⟨10.1177/2050640620967898⟩. ⟨inserm-02996890⟩



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