Cardiovascular Disease in Women, Circulation Research, vol.118, issue.8, pp.1273-1293, 2016. ,
Association of Premature Natural and Surgical Menopause With Incident Cardiovascular Disease, JAMA, vol.322, issue.24, p.2411, 2019. ,
Effect of Sex and Age Interactions on Functional Outcome after Stroke, CNS Neuroscience & Therapeutics, vol.21, issue.4, pp.327-336, 2014. ,
Sex Hormones and Sex Chromosomes Cause Sex Differences in the Development of Cardiovascular Diseases, Arteriosclerosis, Thrombosis, and Vascular Biology, vol.37, issue.5, pp.746-756, 2017. ,
Sex and gender analysis improves science and engineering, Nature, vol.575, issue.7781, pp.137-146, 2019. ,
Policy: NIH to balance sex in cell and animal studies, Nature, vol.509, issue.7500, pp.282-283, 2014. ,
Epigenetic Modifications, Circulation, vol.123, issue.19, pp.2145-2156, 2011. ,
A Year in the Life of the EU-CardioRNA COST Action: CA17129 Catalysing Transcriptomics Research in Cardiovascular Disease, Non-Coding RNA, vol.6, issue.2, p.17, 2020. ,
Author Correction: The role of sex in the genomics of human complex traits, Nature Reviews Genetics, vol.20, issue.8, pp.494-494, 2019. ,
, Articles Accessed in June 2005, Obstetrics & Gynecology, vol.106, issue.3, p.443, 2005.
, Issue Information, Molecular Ecology, vol.29, issue.21, pp.4890-4911, 2020.
Association of the Common Genetic Polymorphisms and Haplotypes of the Chymase Gene with Left Ventricular Mass in Male Patients with Symptomatic Aortic Stenosis, PLoS ONE, vol.9, issue.5, p.e96306, 2014. ,
Identification of a highly specific chymase as the major angiotensin II-forming enzyme in the human heart, J. Biol. Chem, vol.265, pp.22348-22357, 1990. ,
Transforming growth factor (TGF)-? signaling in cardiac remodeling, Journal of Molecular and Cellular Cardiology, vol.51, issue.4, pp.600-606, 2011. ,
Gender differences in hypertension, Current Opinion in Nephrology and Hypertension, vol.27, issue.3, pp.176-181, 2018. ,
Management of Hypercholesterolaemia in Postmenopausal Women, Drugs & Aging, vol.19, issue.3, pp.169-178, 2002. ,
Hypertension in the spontaneously hypertensive rat is linked to the Y chromosome., Hypertension, vol.16, issue.3, pp.277-281, 1990. ,
Review of the Y chromosome and hypertension, Brazilian Journal of Medical and Biological Research, vol.33, issue.6, pp.679-691, 2000. ,
Inheritance of coronary artery disease in men: an analysis of the role of the Y chromosome, The Lancet, vol.379, issue.9819, pp.915-922, 2012. ,
Effect of the Y chromosome on plasma high-density lipoprotein-cholesterol levels in Y-chromosome-consomic mouse strains, BMC Research Notes, vol.7, issue.1, p.393, 2014. ,
Increased High-Density Lipoprotein Cholesterol Levels in Mice With XX Versus XY Sex Chromosomes, Arteriosclerosis, Thrombosis, and Vascular Biology, vol.35, issue.8, pp.1778-1786, 2015. ,
Susceptibility to ischaemic heart disease: Focusing on genetic variants for ATP-sensitive potassium channel beyond traditional risk factors, European Journal of Preventive Cardiology, p.204748732092678, 2020. ,
Ischemic Heart Disease and Heart Failure: Role of Coronary Ion Channels, International Journal of Molecular Sciences, vol.21, issue.9, p.3167, 2020. ,
Sex differences in gene expression in response to ischemia in the human left ventricular myocardium, Human Molecular Genetics, vol.28, issue.10, pp.1682-1693, 2019. ,
Gender aspects in heart failure, Pathophysiology and medical therapy. Arch. Mal. Coeur Vaiss, vol.97, pp.899-908, 2004. ,
Transcriptomic Analysis Identifies the Effect of Beta-Blocking Agents on a Molecular Pathway of Contraction in the Heart and Predicts Response to Therapy, JACC: Basic to Translational Science, vol.1, issue.3, pp.107-121, 2016. ,
Heart Disease and Stroke Statistics?2019 Update: A Report From the American Heart Association, Circulation, vol.139, issue.10, pp.56-528, 2019. ,
Estrogen receptors and human disease: an update, Archives of Toxicology, vol.86, issue.10, pp.1491-1504, 2012. ,
Molecular and Cellular Basis of Cardiovascular Gender Differences, Science, vol.308, issue.5728, pp.1583-1587, 2005. ,
The many faces of estrogen signaling, Biochemia Medica, vol.24, issue.3, pp.329-342, 2014. ,
Estradiol-based postmenopausal hormone therapy and risk of cardiovascular and all-cause mortality, Menopause, vol.22, issue.9, pp.976-983, 2015. ,
, Issue Information, Molecular Ecology, vol.29, issue.21, pp.4890-4912, 2020.
Postmenopausal Hormone Therapy and Risk of Cardiovascular Disease by Age and Years Since Menopause, JAMA, vol.297, issue.13, pp.1465-1477, 2007. ,
Surgical menopause and cardiovascular risks, Menopause, vol.14, issue.Suppl. 1, pp.562-566, 2007. ,
Vascular Aging in Women: is Estrogen the Fountain of Youth?, Frontiers in Physiology, vol.3, p.165, 2012. ,
Timing hypothesis for postmenopausal hormone therapy, Menopause: The Journal of The North American Menopause Society, vol.20, issue.3, pp.342-353, 2013. ,
The Missing ?lnc? between Genetics and Cardiac Disease, Non-Coding RNA, vol.6, issue.1, p.3, 2020. ,
DNA methylation patterns and epigenetic memory, Genes & Development, vol.16, issue.1, pp.6-21, 2002. ,
On the presence and role of human gene-body DNA methylation, Oncotarget, vol.3, issue.4, pp.462-474, 2012. ,
Alterations in cardiac DNA methylation in human dilated cardiomyopathy, EMBO Molecular Medicine, vol.5, issue.3, pp.413-429, 2013. ,
Differential DNA Methylation Correlates with Differential Expression of Angiogenic Factors in Human Heart Failure, PLoS ONE, vol.5, issue.1, p.e8564, 2010. ,
Experimental heart failure modelled by the cardiomyocyte-specific loss of an epigenome modifier, DNMT3B, Journal of Molecular and Cellular Cardiology, vol.82, pp.174-183, 2015. ,
Cardiac Myocyte De Novo DNA Methyltransferases 3a/3b Are Dispensable for Cardiac Function and Remodeling after Chronic Pressure Overload in Mice, PLOS ONE, vol.10, issue.6, p.e0131019, 2015. ,
Epigenetic balance of aberrant Rasal1 promoter methylation and hydroxymethylation regulates cardiac fibrosis, Cardiovascular Research, vol.105, issue.3, pp.279-291, 2015. ,
DNA hydroxymethylation controls cardiomyocyte gene expression in development and hypertrophy, Nature Communications, vol.7, issue.1, 2016. ,
A genome-wide search for new imprinted genes in the human placenta identifies DSCAM as the first imprinted gene on chromosome 21, Eur. J. Hum. Genet, vol.27, pp.49-60, 2018. ,
URL : https://hal.archives-ouvertes.fr/hal-02619386
Transcriptional control: Imprinting insulation, Current Biology, vol.10, issue.12, pp.R463-R465, 2000. ,
IGF2 stimulates fetal growth in a sex- and organ-dependent manner, Pediatric Research, vol.83, issue.1, pp.183-189, 2017. ,
DNA methylation age of human tissues and cell types, Genome Biology, vol.14, issue.10, p.R115, 2013. ,
Elevated PLA2G7 Gene Promoter Methylation as a Gender-Specific Marker of Aging Increases the Risk of Coronary Heart Disease in Females, PLoS ONE, vol.8, issue.3, p.e59752, 2013. ,
PTX3 PROMOTER METHYLATION AND ITS RELATIONSHIP WITH PTX3 PLASMA LEVELS IN MODULATING ACUTE CORONARY SYNDROME RISK, The Gerontologist, vol.55, issue.Suppl_2, pp.407-407, 2015. ,
Cardiovascular disease risk factors and DNA methylation at theLINE-1repeat region in peripheral blood from Samoan Islanders, Epigenetics, vol.6, issue.10, pp.1257-1264, 2011. ,
High-Resolution Profiling of Histone Methylations in the Human Genome, Cell, vol.129, issue.4, pp.823-837, 2007. ,
H3 Lysine 4 Is Acetylated at Active Gene Promoters and Is Regulated by H3 Lysine 4 Methylation, PLoS Genetics, vol.7, issue.3, p.e1001354, 2011. ,
, Issue Information, Molecular Ecology, vol.29, issue.21, pp.4890-4913, 2020.
CaM kinase II selectively signals to histone deacetylase 4 during cardiomyocyte hypertrophy, Journal of Clinical Investigation, vol.116, issue.7, pp.1853-1864, 2006. ,
Class II Histone Deacetylases Act as Signal-Responsive Repressors of Cardiac Hypertrophy, Cell, vol.110, issue.4, pp.479-488, 2002. ,
Dose-dependent Blockade to Cardiomyocyte Hypertrophy by Histone Deacetylase Inhibitors, Journal of Biological Chemistry, vol.278, issue.31, pp.28930-28937, 2003. ,
The lipid-droplet-associated protein ABHD5 protects the heart through proteolysis of HDAC4, Nature Metabolism, vol.1, issue.11, pp.1157-1167, 2019. ,
HDAC6-mediated acetylation of lipid droplet?binding protein CIDEC regulates fat-induced lipid storage, Journal of Clinical Investigation, vol.127, issue.4, pp.1353-1369, 2017. ,
The H3K9 dimethyltransferases EHMT1/2 protect against pathological cardiac hypertrophy, Journal of Clinical Investigation, vol.127, issue.1, pp.335-348, 2016. ,
Sex differences in histone modifications in the neonatal mouse brain, Epigenetics, vol.4, issue.1, pp.47-53, 2009. ,
Examining the contribution of histone modification to sex differences in learning and memory, Learning & Memory, vol.26, issue.9, pp.318-331, 2019. ,
The Mouse Cytosine-5 RNA Methyltransferase NSun2 Is a Component of the Chromatoid Body and Required for Testis Differentiation, Molecular and Cellular Biology, vol.33, issue.8, pp.1561-1570, 2013. ,
MTA Is an Arabidopsis Messenger RNA Adenosine Methylase and Interacts with a Homolog of a Sex-Specific Splicing Factor, The Plant Cell, vol.20, issue.5, pp.1278-1288, 2008. ,
Skewed X-inactivation is common in the general female population, European Journal of Human Genetics, vol.27, issue.3, pp.455-465, 2018. ,
Skewed X-inactivation is common in the general female population, Eur. J. Hum. Genet, vol.27, pp.455-465, 2018. ,
Unusual maintenance of X chromosome inactivation predisposes female lymphocytes for increased expression from the inactive X, Proceedings of the National Academy of Sciences, vol.113, issue.14, pp.E2029-E2038, 2016. ,
Sex differences in autoimmune diseases, Biology of Sex Differences, vol.2, issue.1, p.1, 2011. ,
Structure of a Biologically Active Estrogen Receptor-Coactivator Complex on DNA, Molecular Cell, vol.57, issue.6, pp.1047-1058, 2015. ,
BRG-1 Is Recruited to Estrogen-Responsive Promoters and Cooperates with Factors Involved in Histone Acetylation, Molecular and Cellular Biology, vol.20, issue.20, pp.7541-7549, 2000. ,
The X-Chromosome Has a Different Pattern of Gene Expression in Women Compared With Men With Ischemic Stroke, Stroke, vol.43, issue.2, pp.326-334, 2012. ,
Influence of sex differences on microRNA gene regulation in disease, Biology of Sex Differences, vol.5, issue.1, p.3, 2014. ,
An update on LNCipedia: a database for annotated human lncRNA sequences, Nucleic Acids Research, vol.43, issue.8, pp.4363-4364, 2015. ,
Sex Differences in Cardiovascular Pathophysiology, Circulation, vol.138, issue.2, pp.198-205, 2018. ,
Sex differences in heart failure, Clinical Cardiology, vol.41, issue.2, pp.211-216, 2018. ,
Sex-related differences in chronic heart failure, International Journal of Cardiology, vol.255, pp.145-151, 2018. ,
, Issue Information, Molecular Ecology, vol.29, issue.21, pp.4890-4914, 2020.
Long non-coding RNAs in the failing heart and vasculature, Non-coding RNA Research, vol.3, issue.3, pp.118-130, 2018. ,
Regulatory RNAs in Heart Failure, Circulation, vol.141, issue.4, pp.313-328, 2020. ,
Sex Bias Is Increasingly Prevalent in Preclinical Cardiovascular Research: Implications for Translational Medicine and Health Equity for Women, Circulation, vol.135, issue.6, pp.625-626, 2017. ,
Sex differences in cardiovascular epigenetics?a systematic review, Biology of Sex Differences, vol.9, issue.1, 2018. ,
Epigenetic response to environmental stress: Assembly of BRG1?G9a/GLP?DNMT3 repressive chromatin complex on Myh6 promoter in pathologically stressed hearts, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, vol.1863, issue.7, pp.1772-1781, 2016. ,
Sex-Based Mhrt Methylation Chromatinizes MeCP2 in the Heart, vol.17, pp.288-301, 2019. ,
A Lead ANRIL Polymorphism Is Associated with Elevated CRP Levels in Periodontitis: A Pilot Case-Control Study, PLOS ONE, vol.10, issue.9, p.e0137335, 2015. ,
Myocardial Infarction-Associated Circular RNA Predicting Left Ventricular Dysfunction, Journal of the American College of Cardiology, vol.68, issue.11, pp.1247-1248, 2016. ,
Imprinting disruption of the <i>CDKN1C</i>/<i>KCNQ1OT1</i> domain: the molecular mechanisms causing Beckwith-Wiedemann syndrome and cancer, Cytogenetic and Genome Research, vol.113, issue.1-4, pp.306-312, 2006. ,
Differential methylation of lncRNA KCNQ1OT1 promoter polymorphism was associated with symptomatic cardiac long QT, Epigenomics, vol.9, issue.8, pp.1049-1057, 2017. ,
Cyclin dependent kinase inhibitor 1 C is a female-specific marker of left ventricular function after acute myocardial infarction, International Journal of Cardiology, vol.274, pp.319-325, 2019. ,
X-Inactivation, Imprinting, and Long Noncoding RNAs in Health and Disease, Cell, vol.152, issue.6, pp.1308-1323, 2013. ,
A gene from the region of the human X inactivation centre is expressed exclusively from the inactive X chromosome, Nature, vol.349, issue.6304, pp.38-44, 1991. ,
miRBase: from microRNA sequences to function, Nucleic Acids Research, vol.47, issue.D1, pp.D155-D162, 2018. ,
Role of TLR4/MyD88/NF-?B signaling pathway in coronary microembolization-induced myocardial injury prevented and treated with nicorandil, Biomedicine & Pharmacotherapy, vol.106, pp.776-784, 2018. ,
Long Non-coding RNA HIX003209 Promotes Inflammation by Sponging miR-6089 via TLR4/NF-?B Signaling Pathway in Rheumatoid Arthritis, Frontiers in Immunology, vol.10, 2019. ,
Many X-linked microRNAs escape meiotic sex chromosome inactivation, Nature Genetics, vol.41, issue.4, pp.488-493, 2009. ,
X-inactivation profile reveals extensive variability in X-linked gene expression in females, Nature, vol.434, issue.7031, pp.400-404, 2005. ,
Circulating microRNAs to predict heart failure after acute myocardial infarction in women, Clinical Biochemistry, vol.70, pp.1-7, 2019. ,
Gender and cardiovascular disease: are sex-biased microRNA networks a driving force behind heart failure with preserved ejection fraction in women?, Cardiovascular Research, vol.114, issue.2, pp.210-225, 2017. ,
, Issue Information, Molecular Ecology, vol.29, issue.21, pp.4890-4915, 2020.
Circulating microRNAs have a sex-specific association with metabolic syndrome, Journal of Biomedical Science, vol.20, issue.1, p.72, 2013. ,
MicroRNA-223 regulates Glut4 expression and cardiomyocyte glucose metabolism, Cardiovascular Research, vol.86, issue.3, pp.410-420, 2010. ,
Inhibition of MicroRNA-92a Protects Against Ischemia/Reperfusion Injury in a Large-Animal Model, Circulation, vol.128, issue.10, pp.1066-1075, 2013. ,
MicroRNA-92a Controls Angiogenesis and Functional Recovery of Ischemic Tissues in Mice, Science, vol.324, issue.5935, pp.1710-1713, 2009. ,
MicroRNA-221/222 Family Counteracts Myocardial Fibrosis in Pressure Overload?Induced Heart Failure, Hypertension, vol.71, issue.2, pp.280-288, 2018. ,
microRNA Regulation in Estrogen Receptor-Positive Breast Cancer and Endocrine Therapy, Biological Procedures Online, vol.20, issue.1, 2018. ,
LNCipedia 5: towards a reference set of human long non-coding RNAs, Nucleic Acids Research, vol.47, issue.D1, pp.D135-D139, 2018. ,
HDncRNA: a comprehensive database of non-coding RNAs associated with heart diseases, Database, vol.2018, 2018. ,
Circulating miRNA profiles provide a biomarker for severity of stroke outcomes associated with age and sex in a rat model, Clinical Science, vol.127, issue.2, pp.77-89, 2014. ,
Circulating Levels of miR-574-5p Are Associated with Neurological Outcome after Cardiac Arrest in Women: A Target Temperature Management (TTM) Trial Substudy, Disease Markers, vol.2019, pp.1-10, 2019. ,
Sexual dimorphisms of mRNA and miRNA in human/murine heart disease, PLOS ONE, vol.12, issue.7, p.e0177988, 2017. ,
Vascular Calcification and not Arrhythmia in Idiopathic Atrial Fibrillation Associates with Sex Differences in Diabetic Microvascular Injury miRNA Profiles, MicroRNA, vol.8, issue.2, pp.127-134, 2019. ,
Long Noncoding RNAs in Patients With Acute Myocardial Infarction, Circulation Research, vol.115, issue.7, pp.668-677, 2014. ,
Strategies and Methods for Research on Sex Differences in Brain and Behavior, Endocrinology, vol.146, issue.4, pp.1650-1673, 2005. ,
Identifying the Critical Gaps in Research on Sex Differences in Metabolism Across the Life Span, Endocrinology, vol.159, issue.1, pp.9-19, 2017. ,
Sex as an important biological variable in biomedical research, BMB Reports, vol.51, issue.4, pp.167-173, 2018. ,
Reporting of sex as a variable in cardiovascular studies using cultured cells, Biology of Sex Differences, vol.2, issue.1, p.11, 2011. ,
Animal Models in Cardiovascular Research: Hypertension and Atherosclerosis, BioMed Research International, vol.2015, pp.1-11, 2015. ,
Sex Differences in Animal Models: Focus on Addiction, Pharmacological Reviews, vol.68, issue.2, pp.242-263, 2016. ,
Dietary phytoestrogens present in soy dramatically increase cardiotoxicity in male mice receiving a chemotherapeutic tyrosine kinase inhibitor, Molecular and Cellular Endocrinology, vol.399, pp.330-335, 2015. ,
A Comparison of the Mouse and Human Lipoproteome: Suitability of the Mouse Model for Studies of Human Lipoproteins, Journal of Proteome Research, vol.14, issue.6, pp.2686-2695, 2015. ,
, Issue Information, Molecular Ecology, vol.29, issue.21, pp.4890-4916, 2020.
The Importance of Biological Sex and Estrogen in Rodent Models of Cardiovascular Health and Disease, Circulation Research, vol.118, issue.8, pp.1294-1312, 2016. ,
Sex in basic research: concepts in the cardiovascular field, Cardiovascular Research, vol.113, issue.7, pp.711-724, 2017. ,
URL : https://hal.archives-ouvertes.fr/hal-01608731
Regional Differences in mRNA and lncRNA Expression Profiles in Non-Failing Human Atria and Ventricles, Scientific Reports, vol.8, issue.1, 2018. ,
Identification and Analysis of Human Sex-biased MicroRNAs, Genomics, Proteomics & Bioinformatics, vol.16, issue.3, pp.200-211, 2018. ,
Transcriptome and Functional Profile of Cardiac Myocytes Is Influenced by Biological Sex, Circulation: Cardiovascular Genetics, vol.10, issue.5, 2017. ,
Correction: X-chromosome-linked miR548am-5p is a key regulator of sex disparity in the susceptibility to mitochondria-mediated apoptosis, Cell Death & Disease, vol.10, issue.11, pp.1-12, 2019. ,
MicroRNAs regulating superoxide dismutase 2 are new circulating biomarkers of heart failure, Scientific Reports, vol.7, issue.1, 2017. ,
URL : https://hal.archives-ouvertes.fr/hal-02267416
Estradiol improves cardiovascular function through up-regulation of SOD2 on vascular wall, Redox Biology, vol.3, pp.88-99, 2014. ,
Sex-specific regulation of cardiac microRNAs targeting mitochondrial proteins in pressure overload, Biology of Sex Differences, vol.10, issue.1, pp.1-10, 2019. ,
Inhibition of miR-181a protects female mice from transient focal cerebral ischemia by targeting astrocyte estrogen receptor-?, Molecular and Cellular Neuroscience, vol.82, pp.118-125, 2017. ,
Inhibition of miR-181a protects female mice from transient focal cerebral ischemia by targeting astrocyte estrogen receptor-?, Molecular and Cellular Neuroscience, vol.82, pp.118-125, 2017. ,
The Potential for microRNA Therapeutics and Clinical Research, Frontiers in Genetics, vol.10, 2019. ,
Sexual Dimorphism in the Expression of Mitochondria-Related Genes in Rat Heart at Different Ages, PLOS ONE, vol.10, issue.1, p.e0117047, 2015. ,
Mitochondrial genes as sites of primary action of steroid hormones, Steroids, vol.61, issue.4, pp.226-232, 1996. ,
False positives in MALDI-TOF detection of ER? in mitochondria, Biochemical and Biophysical Research Communications, vol.343, issue.3, pp.707-711, 2006. ,
Mitochondrial localization of estrogen receptor, Proceedings of the National Academy of Sciences, vol.101, issue.12, pp.4130-4135, 2004. ,
Steroid and thyroid hormone receptors in mitochondria, IUBMB Life, vol.60, issue.4, pp.210-223, 2008. ,
Estrogen receptors ? and ? (ER? and ER?) and androgen receptor (AR) in human sperm: localization of ER? and AR in mitochondria of the midpiece, Human Reproduction, vol.20, issue.12, pp.3481-3487, 2005. ,
Mitochondrial noncoding RNA-regulatory network in cardiovascular disease, Basic Research in Cardiology, vol.115, issue.3, 2020. ,
Circulating microRNAs after cardiac arrest*, Critical Care Medicine, vol.40, issue.12, pp.3209-3214, 2012. ,
Noncoding RNAs in Hypertension, Hypertension, vol.74, issue.3, pp.477-492, 2019. ,
MiR-574-5p: A Circulating Marker of Thoracic Aortic Aneurysm, International Journal of Molecular Sciences, vol.20, issue.16, p.3924, 2019. ,
MicroRNA therapeutics for cardiovascular disease: opportunities and obstacles, Nature Reviews Drug Discovery, vol.11, issue.11, pp.860-872, 2012. ,
, Issue Information, Molecular Ecology, vol.29, issue.21, pp.4890-4917, 2020.
Sex differences in response to miRNA-34a therapy in mouse models of cardiac disease: identification of sex-, disease- and treatment-regulated miRNAs, The Journal of Physiology, vol.594, issue.20, pp.5959-5974, 2016. ,
Models of gender differences in cardiovascular disease, Drug Discovery Today: Disease Models, vol.4, issue.4, pp.227-232, 2007. ,
Mitochondria: a central target for sex differences in pathologies, Clinical Science, vol.131, issue.9, pp.803-822, 2017. ,
Genome-wide profiling of the cardiac transcriptome after myocardial infarction identifies novel heart-specific long non-coding RNAs, European Heart Journal, vol.36, issue.6, pp.353-368, 2014. ,
What does the ?four core genotypes? mouse model tell us about sex differences in the brain and other tissues?, Frontiers in Neuroendocrinology, vol.30, issue.1, pp.1-9, 2009. ,
An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause, Journal of Visualized Experiments, vol.150, issue.150, 2019. ,
Measurement of a Comprehensive Sex Steroid Profile in Rodent Serum by High-Sensitive Gas Chromatography-Tandem Mass Spectrometry, Endocrinology, vol.156, issue.7, pp.2492-2502, 2015. ,
Modeling menopause: The utility of rodents in translational behavioral endocrinology research, Maturitas, vol.87, pp.5-17, 2016. ,
Description of Ovariectomy Protocol in Mice, Methods in Molecular Biology, pp.303-309, 2018. ,
Gathering of aging and estrogen withdrawal in vascular dysfunction of senescent accelerated mice, Experimental Gerontology, vol.45, issue.11, pp.868-874, 2010. ,
URL : https://hal.archives-ouvertes.fr/hal-00631687
Ovariectomized rat model of osteoporosis: A practical guide, EXCLI J, vol.19, pp.89-107, 2020. ,
Decreased bioavailability of nitric oxide in aorta from ovariectomized senescent mice. Role of cyclooxygenase, Experimental Gerontology, vol.76, pp.1-8, 2016. ,
Human Sex Hormone-Binding Globulin Gene Expression in Transgenic Mice, Molecular Endocrinology, vol.12, issue.1, pp.123-136, 1998. ,
Measurement of sex steroids in murine blood and reproductive tissues by liquid chromatography?tandem mass spectrometry, The Journal of Steroid Biochemistry and Molecular Biology, vol.121, issue.3-5, pp.611-618, 2010. ,
A Longitudinal Study of Estrous Cyclicity in Aging C57BL/6J Mice: I. Cycle Frequency, Length and Vaginal Cytology1, Biology of Reproduction, vol.27, issue.2, pp.327-339, 1982. ,
Effect of long-term ovariectomy and estrogen replacement on the expression of estrogen receptor gene in female rats, European Journal of Endocrinology, vol.142, pp.307-314, 2000. ,
Atherosclerotic Lesion Development in a Novel Ovary-Intact Mouse Model of Perimenopause, Arteriosclerosis, Thrombosis, and Vascular Biology, vol.25, issue.9, pp.1910-1916, 2005. ,
The VCD Mouse Model of Menopause and Perimenopause for the Study of Sex Differences in Cardiovascular Disease and the Metabolic Syndrome, Physiology, vol.31, issue.4, pp.250-257, 2016. ,
Involvement of microRNA-133 and -29 in cardiac disturbances in diabetic ovariectomized rats, Iran J. Basic Med. Sci, vol.19, pp.1177-1185, 2016. ,
MicroRNA-23a Participates in Estrogen Deficiency Induced Gap Junction Remodeling of Rats by Targeting GJA1, International Journal of Biological Sciences, vol.11, issue.4, pp.390-403, 2015. ,
, Issue Information, Molecular Ecology, vol.29, issue.21, pp.4890-4918, 2020.
Testosterone Protects Against Atherosclerosis in Male Mice by Targeting Thymic Epithelial Cells?Brief Report, Arteriosclerosis, Thrombosis, and Vascular Biology, vol.38, issue.7, pp.1519-1527, 2018. ,
Dihydrotestosterone Treatment Results in Obesity and Altered Lipid Metabolism in Orchidectomized Mice*, Obesity, vol.14, issue.4, pp.662-672, 2006. ,
Modulation of neointimal lesion formation by endogenous androgens is independent of vascular androgen receptor, Cardiovascular Research, vol.103, issue.2, pp.281-290, 2014. ,
Voluntary wheel running and testosterone replacement increases heart angiogenesis through miR-132 in castrated diabetic rats, Physiology International, vol.106, issue.1, pp.48-58, 2019. ,
A Role for Estrogen Receptor-? and Estrogen Receptor-? in Collagen Biosynthesis in Mouse Skin, Journal of Investigative Dermatology, vol.133, issue.1, pp.120-127, 2013. ,
Sources of oestrogen in the testis and reproductive tract of the male, International Journal of Andrology, vol.22, issue.4, pp.211-223, 1999. ,
let-7 MicroRNAs Induce Tamoxifen Sensitivity by Downregulation of Estrogen Receptor ? Signaling in Breast Cancer, Molecular Medicine, vol.17, issue.11-12, pp.1233-1241, 2011. ,
let-7 MicroRNAs Induce Tamoxifen Sensitivity by Downregulation of Estrogen Receptor ? Signaling in Breast Cancer, Molecular Medicine, vol.17, issue.11-12, pp.1233-1241, 2011. ,
microRNA regulation of the expression of the estrogen receptor in endometrial cancer, Mol. Med. Rep, vol.3, pp.387-392, 2010. ,
An Animal Model with a Cardiomyocyte-Specific Deletion of Estrogen Receptor Alpha: Functional, Metabolic, and Differential Network Analysis, PLoS ONE, vol.9, issue.7, p.e101900, 2014. ,
Increased magnitude of relaxation to oestrogen in aorta from oestrogen receptor beta knock-out mice, Journal of Endocrinology, vol.166, issue.2, pp.R5-R9, 2000. ,
GPER/GPR30 and Regulation of Vascular Tone and Blood Pressure, Immunol. Endocr. Metab. Agents Med. Chem, vol.11, pp.255-261, 2011. ,
Activation function 2 (AF2) of estrogen receptor-? is required for the atheroprotective action of estradiol but not to accelerate endothelial healing, Proceedings of the National Academy of Sciences, vol.108, issue.32, pp.13311-13316, 2011. ,
Mutation of the palmitoylation site of estrogen receptor in vivo reveals tissue-specific roles for membrane versus nuclear actions, Proceedings of the National Academy of Sciences, vol.111, issue.2, pp.E283-E290, 2013. ,
URL : https://hal.archives-ouvertes.fr/inserm-01015486
Four Core Genotypes mouse model: localization of the Sry transgene and bioassay for testicular hormone levels, BMC Research Notes, vol.8, issue.1, p.69, 2015. ,
Differential effects of aging and sex on stroke induced inflammation across the lifespan, Experimental Neurology, vol.249, pp.120-131, 2013. ,
Sex differences influencing micro- and macrovascular endothelial phenotype in vitro, The Journal of Physiology, vol.596, issue.17, pp.3929-3949, 2018. ,
Do you know the sex of your cells?, American Journal of Physiology-Cell Physiology, vol.306, issue.1, pp.C3-C18, 2014. ,
Alternatives to amelogenin markers for sex determination in humans and their forensic relevance, Molecular Biology Reports, vol.47, issue.3, pp.2347-2360, 2020. ,
Rapid Sex Determination Using PCR Technique Compared to Classic Cytogenetics, Int. J. Heal. Sci, vol.2, pp.49-52, 2008. ,
XIST and RPS4Y1 long non-coding RNA transcriptome as sex biomarkers in different body fluids, Egyptian Journal of Forensic Sciences, vol.9, issue.1, 2019. ,
, Mario Botta: architectures 1980-1990, Choice Reviews Online, vol.29, issue.09, p.29-4890-29-4890, 1992.
Sex differences in vascular physiology and pathophysiology: estrogen and androgen signaling in health and disease, American Journal of Physiology-Heart and Circulatory Physiology, vol.313, issue.3, pp.H524-H545, 2017. ,
Estrogen Signaling Multiple Pathways to Impact Gene Transcription, Current Genomics, vol.7, issue.8, pp.497-508, 2006. ,
Mechanisms underlying the influence of oestrogen on cardiovascular physiology in women, The Journal of Physiology, vol.597, issue.19, pp.4873-4886, 2019. ,
Endothelial estrogen receptor isoforms and cardiovascular disease, Molecular and Cellular Endocrinology, vol.389, issue.1-2, pp.65-70, 2014. ,
Androgen Receptor Structure, Function and Biology: From Bench to Bedside, Clin. Biochem. Rev, vol.37, pp.3-15, 2016. ,
Estrogen receptor agonists/antagonists in breast cancer therapy: A critical review, vol.71, pp.257-274, 2017. ,
Selective estrogen receptor modulators: tissue specificity and clinical utility, Clinical Interventions in Aging, vol.9, p.1437, 2014. ,
Flavonoids, flavonoid-rich foods, and cardiovascular risk: a meta-analysis of randomized controlled trials, The American Journal of Clinical Nutrition, vol.88, issue.1, pp.38-50, 2008. ,
Membrane and Nuclear Estrogen Receptor Alpha Actions: From Tissue Specificity to Medical Implications, Physiological Reviews, vol.97, issue.3, pp.1045-1087, 2017. ,
URL : https://hal.archives-ouvertes.fr/hal-01533249
Multiple receptors shape the estrogen response pathway and are critical considerations for the future of in vitro-based risk assessment efforts, Critical Reviews in Toxicology, vol.47, issue.7, pp.570-586, 2017. ,
ER?36 ? Another piece of the estrogen puzzle, European Journal of Cell Biology, vol.94, issue.12, pp.611-625, 2015. ,
Differential Effects of Estradiol and Estradiol-BSA Conjugates, Endocrinology, vol.140, issue.11, pp.5455-5458, 1999. ,
Estrogen Dendrimer Conjugates that Preferentially Activate Extranuclear, Nongenomic Versus Genomic Pathways of Estrogen Action, Molecular Endocrinology, vol.20, issue.3, pp.491-502, 2006. ,
Non-nuclear estrogen receptor ? signaling promotes cardiovascular protection but not uterine or breast cancer growth in mice, Journal of Clinical Investigation, vol.120, issue.7, pp.2319-2330, 2010. ,
Design of pathway preferential estrogens that provide beneficial metabolic and vascular effects without stimulating reproductive tissues, Science Signaling, vol.9, issue.429, pp.ra53-ra53, 2016. ,
Endocrine Response Phenotypes Are Altered by Charcoal-Stripped Serum Variability, Endocrinology, vol.157, issue.10, pp.3760-3766, 2016. ,
Control of proliferation of MCF-7 breast cancer cells in a commercial preparation of charcoal-stripped adult bovine serum, Breast Cancer Research and Treatment, vol.23, issue.1-2, pp.97-104, 1992. ,
Estrogenic activity of phenol red, Molecular and Cellular Endocrinology, vol.57, issue.3, pp.169-178, 1988. ,
Phenol red in tissue culture media is a weak estrogen: implications concerning the study of estrogen-responsive cells in culture., Proceedings of the National Academy of Sciences, vol.83, issue.8, pp.2496-2500, 1986. ,
, Figure 2?figure supplement 1. Representative images used in the experiment, sampled from http://commons.wikimedia.org/wiki/Main_Page under the Creative Commons Attribution 4.0 International Public License https://creativecommons.org/licenses/by/4.0/., © 2020 by the authors. Licensee MDPI