P. Ponka, Cellular iron metabolism, Kidney Int Suppl, vol.69, pp.2-11, 1999.

M. G. Yefimova, J. C. Jeanny, and X. Guillonneau, Iron, ferritin, transferrin, and transferrin receptor in the adult rat retina, Invest Ophthalmol Vis Sci, vol.41, pp.2343-2351, 2000.
URL : https://hal.archives-ouvertes.fr/hal-02695689

P. Hahn, T. Dentchev, Y. Qian, T. Rouault, Z. L. Harris et al., Immunolocalization and regulation of iron handling proteins ferritin and ferroportin in the retina, Mol Vis, vol.10, pp.598-607, 2004.

X. He, P. Hahn, and J. Iacovelli, Iron homeostasis and toxicity in retinal degeneration, Prog Retin Eye Res, vol.26, pp.649-673, 2007.

J. P. Gnana-prakasam, P. M. Martin, B. A. Mysona, P. Roon, S. B. Smith et al., Hepcidin expression in mouse retina and its regulation via lipopolysaccharide/Toll-like receptor-4 pathway independent of Hfe, Biochem J, vol.411, issue.1, pp.79-88, 2008.

W. Chen, H. Lu, K. Dutt, A. Smith, D. M. Hunt et al., Expression of the protective proteins hemopexin and haptoglobin by cells of the neural retina, Exp Eye Res, vol.67, issue.1, pp.83-93, 1998.

J. P. Gnana-prakasam, M. Zhang, P. M. Martin, S. S. Atherton, S. B. Smith et al., Expression of the iron-regulatory protein haemojuvelin in retina and its regulation during cytomegalovirus infection, Biochem J, vol.419, issue.3, pp.533-576, 2009.

M. G. Yefimova, J. C. Jeanny, and N. Keller, Impaired retinal iron homeostasis associated with defective phagocytosis in Royal College of Surgeons rats, Invest Ophthalmol Vis Sci, vol.43, pp.537-545, 2002.

E. Tolosano, S. Fagoonee, N. Morello, F. Vinchi, and V. Fiorito, Heme scavenging and the other facets of hemopexin, Antioxid Redox Signal, vol.12, pp.305-320, 2010.

J. Iacovelli, A. E. Mlodnicka, P. Veldman, G. S. Ying, and J. L. Dunaief, Schumacher A. Brain and retinal ferroportin 1 dysregulation in polycythaemia mice, Brain Res, vol.1289, pp.85-95, 2009.

J. P. Gnana-prakasam, M. Thangaraju, and K. Liu, Absence of ironregulatory protein Hfe results in hyperproliferation of retinal pigment epithelium: role of cystine/glutamate exchanger, Biochem J, vol.424, pp.243-252, 2009.

H. Chen, B. Liu, T. J. Lukas, G. Suyeoka, G. Wu et al., Changes in iron-regulatory proteins in the aged rodent neural retina, Neurobiol Aging, vol.30, pp.1865-1876, 2009.

H. Chen, T. J. Lukas, N. Du, G. Suyeoka, and A. H. Neufeld, Dysfunction of the retinal pigment epithelium with age: increased iron decreases phagocytosis and lysosomal activity, Invest Ophthalmol Vis Sci, vol.50, issue.4, pp.1895-1902, 2009.

N. Morello, E. Tonoli, and F. Logrand, Hemopexin affects iron distribution and ferritin expression in mouse brain, J Cell Mol Med, vol.13, pp.4102-4204, 2009.

P. Hahn, A. H. Milam, and J. L. Dunaief, Maculas affected by age-related macular degeneration contain increased chelatable iron in the retinal pigment epithelium and Bruch's membrane, Arch Ophthalmol, vol.121, pp.1099-1105, 2003.

T. Dentchev, P. Hahn, and J. L. Dunaief, Strong labeling for iron and the iron-handling proteins ferritin and ferroportin in the photoreceptor layer in age-related macular degeneration, Arch Ophthalmol, vol.123, pp.1745-1746, 2005.

P. M. Harrison and P. Arosio, The ferritins: molecular properties, iron storage function and cellular regulation, Biochim Biophys Acta, vol.1275, pp.161-203, 1996.

S. Epsztejn, H. Glickstein, and V. Picard, H-ferritin subunit overexpression in erythroid cells reduces the oxidative stress response and induces multidrug resistance properties, Blood, vol.94, pp.3593-3603, 1999.

K. Orino, L. Lehman, Y. Tsuji, H. Ayaki, S. V. Torti et al., Ferritin and the response to oxidative stress, Biochem J, vol.357, pp.241-247, 2001.

A. Cozzi, B. Corsi, S. Levi, P. Santambrogio, A. Albertini et al., Overexpression of wild type and mutated human ferritin H-chain in HeLa cells: in vivo role of ferritin ferroxidase activity, J Biol Chem, vol.275, pp.25122-25129, 2000.

C. Ferreira, D. Bucchini, and M. E. Martin, Early embryonic lethality of H ferritin gene deletion in mice, J Biol Chem, vol.275, issue.5, pp.3021-3024, 2000.

C. Ferreira, P. Santambrogio, and M. E. Martin, H ferritin knockout mice: a model of hyperferritinemia in the absence of iron overload, Blood, vol.98, pp.525-532, 2001.

H. Yamashita, K. Horie, T. Yamamoto, T. Nagano, and T. Hirano, Light-induced retinal damage in mice: hydrogen peroxide production and superoxide dismutase activity in retina, Retina, vol.12, pp.59-66, 1992.

K. J. Cruickshanks, R. Klein, and B. E. Klein, Sunlight and age-related macular degeneration. The Beaver Dam Eye Study, Arch Ophthalmol, vol.111, pp.514-518, 1993.

C. Grimm, A. Wenzel, T. Williams, P. Rol, F. Hafezi et al., Rhodopsin-mediated blue-light damage to the rat retina: effect of photoreversal of bleaching, Invest Ophthalmol Vis Sci, vol.42, pp.497-505, 2001.

D. T. Organisciak, R. M. Darrow, and L. Barsalou, Light history and age-related changes in retinal light damage, Invest Ophthalmol Vis Sci, vol.39, pp.1107-1116, 1998.

A. Wenzel, C. Grimm, M. Samardzija, and C. E. Reme, Molecular mechanisms of light-induced photoreceptor apoptosis and neuroprotection for retinal degeneration, Prog Retin Eye Res, vol.24, pp.275-306, 2005.

S. R. Chandra, E. S. Gragoudas, E. Friedman, E. M. Van-buskirk, and M. L. Klein, Natural history of disciform degeneration of the macula, Am J Ophthalmol, vol.78, pp.579-582, 1974.

R. E. Anderson, F. L. Kretzer, and L. M. Rapp, Free radicals and ocular disease, Adv Exp Med Biol, vol.366, pp.73-86, 1994.

J. R. Sparrow, J. Zhou, S. Ben-shabat, H. Vollmer, Y. Itagaki et al., Involvement of oxidative mechanisms in blue-light-induced damage to A2E-laden RPE, Invest Ophthalmol Vis Sci, vol.43, pp.1222-1227, 2002.

A. Rattner and J. Nathans, The genomic response to retinal disease and injury: evidence for endothelin signaling from photoreceptors to glia, J Neurosci, vol.25, pp.4540-4549, 2005.

P. Santambrogio, A. Cozzi, and S. Levi, Functional and immunological analysis of recombinant mouse H-and L-ferritins from Escherichia coli, Protein Expr Purif, vol.19, pp.212-218, 2000.

R. D. Wiegand, N. M. Giusto, L. M. Rapp, and R. E. Anderson, Evidence for rod outer segment lipid peroxidation following constant illumination of the rat retina, Invest Ophthalmol Vis Sc, vol.24, pp.1433-1435, 1983.

R. Wen, T. Cheng, and Y. Song, Continuous exposure to bright light upregulates bFGF and CNTF expression in the rat retina, Curr Eye Res, vol.17, pp.494-500, 1998.

T. F. Ng and J. W. Streilein, Light-induced migration of retinal microglia into the subretinal space, Invest Ophthalmol Vis Sci, vol.42, pp.3301-3310, 2001.

W. Raoul, N. Keller, M. Rodero, F. Behar-cohen, F. Sennlaub et al., Role of the chemokine receptor CX3CR1 in the mobilization of phagocytic retinal microglial cells, J Neuroimmunol, vol.198, pp.56-61, 2008.
URL : https://hal.archives-ouvertes.fr/inserm-00311574

C. M. Ethen, C. Reilly, X. Feng, T. W. Olsen, and D. A. Ferrington, Age-related macular degeneration and retinal protein modification by 4-hydroxy-2-nonenal, Invest Ophthalmol Vis Sci, vol.48, pp.3469-3479, 2007.

L. Chen, T. Dentchev, and R. Wong, Increased expression of ceruloplasmin in the retina following photic injury, Mol Vis, vol.9, pp.151-158, 2003.

P. Hahn, G. S. Ying, J. Beard, and J. L. Dunaief, Iron levels in human retina: sex difference and increase with age, Neuroreport, vol.17, pp.1803-1806, 2006.

M. Hadziahmetovic, T. Dentchev, and Y. Song, Ceruloplasmin/ hephaestin knockout mice model morphologic and molecular features of AMD, Invest Ophthalmol Vis Sci, vol.49, pp.2728-2736, 2008.

P. Hahn, Y. Song, G. S. Ying, X. He, J. Beard et al., Age-dependent and gender-specific changes in mouse tissue iron by strain, Exp Gerontol, vol.44, pp.594-600, 2009.

C. Sergeant, B. Gouget, and Y. Llabador, Iron in hereditary retinal degeneration : PIXE microanalysis-preliminary results, Nuclear Instr Methods Phys Res B, vol.158, pp.344-348, 1999.

L. M. Rapp and T. P. Williams, The role of ocular pigmentation in protecting against retinal light damage, Vision Res, vol.20, pp.1127-1131, 1980.

R. A. Williams, A. G. Howard, and T. P. Williams, Retinal damage in pigmented and albino rats exposed to low levels of cyclic light following a single mydriatic treatment, Curr Eye Res, vol.4, pp.97-102, 1985.

M. P. White and L. J. Fisher, Degree of light damage to the retina varies with time of day of bright exposure to light, Physiol Behav, vol.39, pp.607-613, 1987.

S. Levi, P. Santambrogio, and A. Cozzi, The role of the L-chain in ferritin iron incorporation: studies of homo and heteropolymers, J Mol Biol, vol.238, pp.649-654, 1994.

S. Levi, S. J. Yewdall, and P. M. Harrison, Evidence of H-and L-chains have co-operative roles in the iron-uptake mechanism of human ferritin, Biochem J, vol.288, pp.591-596, 1992.

D. Darshan, L. Vanoaica, L. Richman, F. Beermann, and L. C. Kuhn, Conditional deletion of ferritin H in mice induces loss of iron storage and liver damage, Hepatology, vol.50, issue.3, pp.852-860, 2009.

D. T. Organisciak, R. M. Darrow, L. Barsalou, R. K. Kutty, and B. Wiggert, Circadian-dependent retinal light damage in rats, Invest Ophthalmol Vis Sci, vol.41, pp.3694-3701, 2000.

P. M. Iuvone, G. Tosini, N. Pozdeyev, R. Haque, D. C. Klein et al., Circadian clocks, clock networks, arylalkylamine N-acetyltransferase, and melatonin in the retina, Prog Retin Eye Res, vol.24, pp.433-456, 2005.

E. Picard, I. Fontaine, and L. Jonet, The protective role of transferrin in Müller glial cells after iron-induced toxicity, Mol Vis, vol.14, pp.928-941, 2008.

J. R. Burdo, D. A. Antonetti, E. B. Wolpert, and J. R. Connor, Mechanisms and regulation of transferrin and iron transport in a model blood-brain barrier system, Neuroscience, vol.121, pp.883-890, 2003.

E. Nemeth, M. S. Tuttle, and J. Powelson, Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization, Science, vol.17, pp.2090-2093, 2004.

R. K. Kutty, G. Kutty, B. Wiggert, G. J. Chader, R. M. Darrow et al., Induction of heme oxygenase 1 in the retina by intense visible light: suppression by the antioxidant dimethylthiourea, Proc Natl Acad Sci USA, vol.92, pp.1177-1181, 1995.

S. Moore and S. Thanos, The concept of microglia in relation to central nervous system disease and regeneration, Prog Neurobiol, vol.48, pp.441-460, 1996.

C. Zhang, J. K. Shen, and T. T. Lam, Activation of microglia and chemokines in light-induced retinal degeneration, Mol Vis, vol.11, pp.887-895, 2005.

C. Gerhardinger, M. B. Costa, M. C. Coulombe, I. Toth, T. Hoehn et al., Expression of acute-phase response proteins in retinal Müller cells in diabetes, Invest Ophthalmol Vis Sci, vol.46, pp.349-357, 2005.

K. Iwasaki, K. Hailemariam, and Y. Tsuji, PIAS3 interacts with ATF1 and regulates the human ferritin H gene through an antioxidant-responsive element, J Biol Chem, vol.282, pp.22335-22343, 2007.

A. Cozzi, B. Corsi, S. Levi, P. Santambrogio, A. Albertini et al., Overexpression of wild type and mutated human ferritin H-chain in HeLa cells: in vivo role of ferritin ferroxidase activity, J Biol Chem, vol.275, pp.25122-25129, 2000.

A. Cozzi, B. Corsi, S. Levi, P. Santambrogio, G. Biasiotto et al., Analysis of the biologic functions of H-and L-ferritins in HeLa cells by transfection with siRNAs and cDNAs: evidence for a proliferative role of L-ferritin, Blood, vol.103, pp.2377-2383, 2004.

J. Han, J. R. Day, K. Thomson, J. R. Connor, and J. L. Beard, Iron deficiency alters H-and L-ferritin expression in rat brain, Cell Mol. Biol, vol.46, pp.517-528, 2000.

N. Lukinova, I. Iacovelli, and T. Dentchev, Iron chelation protects the retinal pigment epithelial cell line ARPE-19 against cell death triggered by diverse stimuli, Invest Ophthalmol Vis Sci, vol.50, issue.3, pp.1440-1447, 2009.