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Article dans Bulletin de l'Académie Nationale de Médecine FER ET PROTEINES REGULATRICES DANS LA RETINE NORMALE ET PATHOLOGIQUE

Abstract : Iron is necessary for cell metabolism, but excess iron can be toxic Iron can generate oxygen free radicals through the Fenton reaction. Iron accumulation has been observed in the retina of patients with age-related macular degeneration (AMD). We have shown its accumulation in photoreceptor segments in two animal models of genetic retinal degeneration (RCS rats and Rd10 mice). In these rodents, hTf, injected intraperitoneally or expressed by genetic modification, delayed photoreceptor degeneration. Our studies highlight the therapeutic potential of Tf in degenerative processes such as retinitis pigmentosa and AMD.
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https://www.hal.inserm.fr/inserm-02983671
Contributor : Emilie Picard <>
Submitted on : Friday, October 30, 2020 - 10:43:11 AM
Last modification on : Wednesday, December 9, 2020 - 3:08:18 PM
Long-term archiving on: : Sunday, January 31, 2021 - 6:13:23 PM

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  • HAL Id : inserm-02983671, version 1
  • PUBMED : 25163348

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Jean-Claude Jeanny, Émilie Picard, Claire Sergeant, Laurent Jonet, Marina Yefimova, et al.. Article dans Bulletin de l'Académie Nationale de Médecine FER ET PROTEINES REGULATRICES DANS LA RETINE NORMALE ET PATHOLOGIQUE. Bulletin de l'Académie Nationale de Médecine, Elsevier Masson, 2013, 197 (3), pp.661-74; discussion 674-5. ⟨inserm-02983671⟩

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