Retinal iron homeostasis in health and disease, Front. Aging Neurosci, vol.5, pp.1-13, 2013. ,
From Rust to Quantum Biology: The Role of Iron in Retina Physiopathology, Cells, vol.2020, p.705 ,
URL : https://hal.archives-ouvertes.fr/hal-02586954
Differential sensitivity of cones to iron-mediated oxidative damage, Investig. Opthalmol. Vis. Sci, vol.48, pp.438-445, 2007. ,
Ferroptosis: An iron-dependent form of nonapoptotic cell death, Cell, vol.149, pp.1060-1072, 2012. ,
Iron Overload Accelerates the Progression of Diabetic Retinopathy in Association with Increased Retinal Renin Expression, Sci. Rep, vol.8, pp.1-12, 2018. ,
Iron is neurotoxic in retinal detachment and transferrin confers neuroprotection ,
Membranes of retinal pigment epithelial cells in vitro are damaged in the phagocytotic process of the photoreceptor outer segment discs peroxidized by ferrous ions, Pigment Cell Res, vol.15, pp.341-347, 2002. ,
Dysfunction of the retinal pigment epithelium with age: Increased iron decreases phagocytosis and lysosomal activity, Investig. Opthalmol. Vis. Sci, vol.50, pp.1895-1902, 2009. ,
Ferrous but not ferric iron sulfate kills photoreceptors and induces photoreceptor-dependent RPE autofluorescence ,
Maculas Affected by Age-Related Macular Degeneration Contain Increased Chelatable Iron in the Retinal Pigment Epithelium and Bruch's Membrane, Arch. Opthalmol, vol.121, pp.1099-1105, 2003. ,
Strong labeling for iron and the iron-handling proteins ferritin and ferroportin in the photoreceptor layer in age-related macular degenerationNo Title, Arch. Opthalmol, vol.123, pp.1745-1746, 2005. ,
Iron accumulation in Bruch's membrane and melanosomes of donor eyes with age-related macular degeneration, Exp. Eye Res, vol.137, pp.39-49, 2015. ,
Levels of Aqueous Humor Trace Elements in Patients with Non-Exsudative Age-related Macular Degeneration: A Case-control Study, PLoS ONE, vol.8, 2013. ,
The iron carrier transferrin is upregulated in retinas from patients with age-related macular degeneration, Investig. Opthalmol. Vis. Sci, vol.47, pp.2135-2140, 2006. ,
Transferrin receptor levels and polymorphism of its gene in age-related macular degeneration, Acta Biochim. Pol, vol.62, pp.177-184, 2015. ,
Genetic polymorphism of the iron-regulatory protein-1 and-2 genes in age-related macular degeneration, Mol. Biol. Rep, vol.39, pp.7077-7087, 2012. ,
An association between polymorphism of the heme oxygenase-1 and-2 genes and age-related macular degeneration, Mol. Biol. Rep, vol.39, pp.2081-2087, 2012. ,
Impaired retinal iron homeostasis associated with defective phagocytosis in Royal College of surgeons rats, Investig. Opthalmol. Vis. Sci, vol.43, pp.537-545, 2002. ,
Overexpressed or intraperitoneally injected human transferrin prevents photoreceptor degeneration in rd10 mice, Mol. Vis, vol.16, pp.2612-2625, 2010. ,
Alteration in iron metabolism during retinal degeneration in rd10 mouse, Investig. Opthalmol. Vis. Sci, vol.50, pp.1360-1365, 2009. ,
Mutations in FLVCR1 cause posterior column ataxia and retinitis pigmentosa, Am. J. Hum. Genet, vol.87, pp.643-654, 2010. ,
The oral iron chelator deferiprone protects against iron overload-induced retinal degeneration, Investig. Opthalmol. Vis. Sci, vol.52, pp.959-968, 2011. ,
Systemic administration of the antioxidant/iron chelator ?-lipoic acid protects against light-induced photoreceptor degeneration in the mouse retina, Investig. Opthalmol. Vis. Sci, vol.55, pp.5979-5988, 2014. ,
Zinc-desferrioxamine attenuates retinal degeneration in the rd10 mouse model of retinitis pigmentosa. Free Radic, Biol. Med, vol.51, pp.1482-1491, 2011. ,
The Oral Iron Chelator Deferiprone Protects Against Retinal Degeneration Induced through Diverse Mechanisms, Transl. Vis. Sci. Technol, vol.1, issue.2, 2012. ,
Iron-chelating drugs enhance cone photoreceptor survival in a mouse model of retinitis pigmentosa, Investig. Opthalmol. Vis. Sci, vol.58, pp.5287-5297, 2017. ,
Deferoxamine (Desferal)-induced toxic retinal pigmentary degeneration and presumed optic neuropathyitle, Opthalmology, vol.91, pp.443-452, 1984. ,
The protective role of transferrin in Müller glial cells after iron-induced toxicity, Mol. Vis, vol.14, pp.928-941, 2008. ,
Light-induced retinal degeneration correlates with changes in iron metabolism gene expression, ferritin level, and aging, Investig. Opthalmol. Vis. Sci, vol.52, pp.1261-1274, 2011. ,
Targeting iron-mediated retinal degeneration by local delivery of transferrin. Free Radic, Biol. Med, vol.89, pp.1105-1121, 2015. ,
URL : https://hal.archives-ouvertes.fr/inserm-02980617
Contribution of plasma proteins to the vitreous of the rat, Curr. Eye Res, vol.5, pp.655-663, 1986. ,
Plasmid electrotransfer of eye ciliary muscle: Principles and therapeutic efficacy using hTNF-? soluble receptor in uveitis, FASEB J, vol.20, pp.389-391, 2006. ,
Protein delivery for retinal diseases: From basic considerations to clinical applications, Prog. Retin. Eye Res, vol.29, pp.443-465, 2010. ,
Non-viral ocular gene therapy, pEYS606, for the treatment of non-infectious uveitis: Preclinical evaluation of the medicinal product, J. Control, vol.285, pp.244-251, 2018. ,
Ocular gene therapies in clinical practice: Viral vectors and nonviral alternatives, Drug Discov. Today, vol.24, pp.1685-1693, 2019. ,
URL : https://hal.archives-ouvertes.fr/hal-02303632
The ciliary smooth muscle electrotransfer: Basic principles and potential for sustained intraocular production of therapeutic proteins, J. Gene Med, vol.12, pp.904-919, 2010. ,
Improved antibiotic-free plasmid vector design by incorporation of transient expression enhancers, Gene Ther, vol.18, pp.334-343, 2011. ,
Development of Antibiotic-Free Selection System for Safer DNA Vaccination, DNA Vaccines, vol.1143, pp.91-111, 2014. ,
The temporal topography of the N-Methyl-N-nitrosourea induced photoreceptor degeneration in mouse retina, Sci. Rep, vol.5, pp.1-14, 2015. ,
Caspase-3 inhibitor rescues N-methyl-N-nitrosourea-induced retinal degeneration in Sprague-Dawley rats, Exp. Eye Res, vol.71, pp.629-635, 2000. ,
Mild and selective labeling of malondialdehyde with 2-aminoacridone: Assessment of urinary malondialdehyde levels, Analyst, vol.136, pp.2763-2769, 2011. ,
Light-induced retinal damage using different light sources, protocols and rat strains reveals LED phototoxicity, Neuroscience, vol.339, pp.296-307, 2016. ,
URL : https://hal.archives-ouvertes.fr/hal-01383394
Protective effect of carnosic acid, a pro-electrophilic compound, in models of oxidative stress and light-induced retinal degeneration, Investig. Opthalmol. Vis. Sci, vol.53, pp.7847-7854, 2012. ,
Role of oxidative stress in retinal photoreceptor cell death in N-methyl-N-nitrosourea-treated mice, J. Pharmacol. Sci, vol.118, pp.351-362, 2012. ,
Photoreceptor apoptosis induced by a single systemic administration of N-methyl-N-nitrosourea in the rat retina, Am. J. Pathol, vol.148, pp.631-641, 1996. ,
Pigmentary degeneration induced by N-met hyl-N-nitrosourea and the fate of pigment epithelial cells in the rat retina, Pathol. Int, vol.46, pp.874-882, 1996. ,
Mechanisms of photoreceptor cell apoptosis induced by N-methyl-N-nitrosourea in Sprague-Dawley rats, Lab. Investig, vol.79, pp.1359-1367, 1999. ,
Inherited retinal dystrophy: Primary defect in pigment epithelium determined with experimental rat chimeras, Science, vol.192, pp.799-801, 1976. ,
Homozygous deletion in the coding sequence of the c-mer gene in RCS rats unravels general mechanisms of physiological cell adhesion and apoptosis, Neurobiol. Dis, vol.7, pp.586-599, 2000. ,
Early events in retinal degeneration caused by rhodopsin mutation or pigment epithelium malfunction: Differences and similarities, Front. Neuroanat, vol.11, 2017. ,
Lipid peroxidation-derived aldehydes, 4-hydroxynonenal and malondialdehyde in aging-related disorders, Antioxidants, vol.7, p.102, 2018. ,
A review of recent studies on malondialdehyde as toxic molecule and biological marker of oxidative stress, Nutr. Metab. Cardiovasc. Dis, vol.15, pp.316-328, 2005. ,
Local ocular immunomodulation resulting from electrotransfer of plasmid encoding soluble TNF receptors in the ciliary muscle, Investig. Opthalmol. Vis. Sci, vol.50, pp.1761-1768, 2009. ,
URL : https://hal.archives-ouvertes.fr/hal-02421775
Long-term efficacy of ciliary muscle gene transfer of three sFlt-1 variants in a rat model of laser-induced choroidal neovascularization, Gene Ther, vol.20, pp.1093-1103, 2013. ,
Non-viral gene therapy for GDNF production in RCS rat: The crucial role of the plasmid dose, Gene Ther, vol.19, pp.886-898, 2012. ,
Retinal damage by light in rats, Investig. Opthalmol, vol.5, pp.450-473, 1966. ,
Light damage induced changes in mouse retinal gene expression, Exp. Eye Res, vol.79, pp.239-247, 2004. ,
Molecular mechanisms of light-induced photoreceptor apoptosis and neuroprotection for retinal degeneration, Prog. Retin. Eye Res, vol.24, pp.275-306, 2005. ,
Oxidative damage is a potential cause of cone cell death in retinitis pigmentosa, J. Cell. Physiol, vol.203, pp.457-464, 2005. ,
Extreme retinal remodeling triggered by light damage: Implications for age related macular degeneration, Mol. Vis, vol.14, pp.782-806, 2008. ,
Microarray analysis of murine retinal light damage reveals changes in iron regulatory, complement, and antioxidant genes in the neurosensory retina and isolated RPE, Investig. Opthalmol. Vis. Sci, vol.53, pp.5231-5241, 2012. ,
Topography of retinal damage in light-exposed albino rats, Exp. Eye Res, vol.87, pp.292-295, 2008. ,
Inhalation of growth factors and apo-transferrin to protect and repair the hypoxic-ischemic brain, Pharmacol. Res, vol.109, pp.81-85, 2016. ,
Calpain Inhibition Restores Basal Autophagy and Suppresses MNU-induced Photoreceptor Cell Death in Mice, vol.25, pp.617-624, 2011. ,
Antioxidants reduce cone cell death in a model of retinitis pigmentosa, Proc. Natl. Acad. Sci, vol.103, pp.11300-11305, 2006. ,
NADPH oxidase plays a central role in cone cell death in retinitis pigmentosa, J. Neurochem, vol.110, pp.1028-1037, 2009. ,
Is There Excess Oxidative Stress and Damage in Eyes of Patients with Retinitis Pigmentosa?, Antioxid. Redox Signal, vol.23, pp.643-648, 2015. ,
Mutation of the receptor tyrosine kinase gene Mertk in the retinal dystrophic RCS rat, Hum. Mol. Genet, vol.9, pp.645-651, 2000. ,
AAV-mediated gene transfer slows photoreceptor loss in the RCS rat model of retinitis pigmentosa, Mol. Ther, vol.8, pp.188-195, 2003. ,
Long-term preservation of retinal function in the RCS rat model of retinitis pigmentosa following lentivirus-mediated gene therapy, Gene Ther, vol.12, pp.694-701, 2005. ,
A simple fluorometric assay for lipoperoxide in blood plasma, Biochem. Med, vol.15, pp.212-216, 1976. ,
Potential treatment of retinal diseases with iron chelators, Pharmaceuticals, vol.11, 2018. ,
Iron levels in human retina: Sex difference and increase with age, Neuroreport, vol.17, pp.1803-1806, 2006. ,
Human RPE melanosomes protect from photosensitized and iron-mediated oxidation but become pro-oxidant in the presence of iron upon photodegradation, Investig. Opthalmol. Vis. Sci, vol.49, pp.2838-2847, 2008. ,