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Journal articles
The antidiabetic drug glibenclamide exerts direct retinal neuroprotection: Glibenclamide exerts retinal neuroprotection
Marianne Berdugo
1
Kimberley Delaunay
1
Marie-Christine Naud
1
Justine Guegan
2
Alexandre Moulin
3
Michèle Savoldelli
4
Émilie Picard
1
Lolita Radet
1
Laurent Jonet
1
Zoubir Djerada
5
Claire Gozalo
6
Alejandra Daruich
7
Jacques Beltrand
8, 9
Jean-Claude Jeanny
1
Elsa Kermorvant-Duchemin
10
Patricia Crisanti
1
Michel Polak
8, 9
Francine Behar-Cohen
1
Marianne Berdugo 1
Author
Kimberley Delaunay 1
Author
Marie-Christine Naud 1
Author
Justine Guegan 2
Author
Alexandre Moulin 3
Author
Michèle Savoldelli 4
Author
Émilie Picard 1
Author IdHAL : emilie-picard
Lolita Radet 1
Author
Jacques Beltrand 8, 9
Author
Jean-Claude Jeanny 1
Author
Elsa Kermorvant-Duchemin 10
Author
Patricia Crisanti 1
Author
Michel Polak 8, 9
Author
Francine Behar-Cohen 1
Author
1
CRC (UMR_S_1138 / U1138) - Centre de Recherche des Cordeliers (15 rue de l'Ecole de Médecine - Bâtiment B -
75270 Paris Cedex 06 - France)
- EPHE - École pratique des hautes études (4-14 Rue Ferrus, 75014 Paris - France)
- PSL - Université Paris sciences et lettres (60 rue Mazarine 75006 Paris - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1138 (101, rue de Tolbiac, 75013 Paris - France)
- SU - Sorbonne Université (21 rue de l’École de médecine - 75006 Paris - France)
- UP - Université de Paris : UMR_S_1138 (85 boulevard Saint-Germain 75006 Paris - France)
2
Plateforme iCONICS [Paris] (France)
- ICM - Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (47-83 Boulevard de l'Hôpital 75651 Paris Cedex 13 - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1127 (101, rue de Tolbiac, 75013 Paris - France)
- CHU Pitié-Salpêtrière [AP-HP] (47-83 Boulevard de l'Hôpital, 75013 Paris - France)
- Sorbonne Université (France)
- AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP) (France)
- SU - Sorbonne Université : UM75 (21 rue de l’École de médecine - 75006 Paris - France)
- CNRS - Centre National de la Recherche Scientifique : UMR7225 (France)
3
UNIL - Université de Lausanne (CH-1015 Lausanne - Switzerland)
4
Laboratoire Biotechnologie et Œil (1, place du Parvis Notre Dame, 75181 Paris cedex 04 - France)
- UPD5 - Université Paris Descartes - Paris 5 (12, rue de l'École de Médecine - 75270 Paris cedex 06 - France)
- Hôpital Hôtel-Dieu [Paris] (1, place du Parvis Notre-Dame 75004 Paris - France)
5
Laboratoire de Pharmacologie et Toxicologie [CHU Reims] (France)
- CHU Reims - Centre Hospitalier Universitaire de Reims (45, rue Cognacq-Jay 51100 Reims - France)
6
Laboratoire de Pharmacologie-Toxicologie [CHU de Dijon] (CHU de Dijon - 14 rue Paul Gaffarel - 21079 Dijon - France)
- CHU Dijon - Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon - 14 rue Paul Gaffarel - 21079 Dijon - France)
7
Service d'ophtalmologie [CHU Necker] (CHU Necker - 149 rue de Sèvres 75015 Paris - France)
- AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP) (France)
- CHU Necker - Enfants Malades [AP-HP] (149 Rue de Sèvres 75015 Paris - France)
8
IC UM3 (UMR 8104 / U1016) - Institut Cochin (22 rue Méchain, 75014 Paris - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1016 (101, rue de Tolbiac, 75013 Paris - France)
- CNRS - Centre National de la Recherche Scientifique : UMR 8104 (France)
- UP - Université de Paris : UM 3 (85 boulevard Saint-Germain 75006 Paris - France)
9
Imagine - U1163 - Imagine - Institut des maladies génétiques (IHU) (IHU Imagine,
156 rue de Vaugirard, 75015 PARIS
et
24 Boulevard du Montparnasse, 75015 Paris - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1163 (101, rue de Tolbiac, 75013 Paris - France)
- CNRS - Centre National de la Recherche Scientifique (France)
- UP - Université de Paris : UMR_S 1163 (85 boulevard Saint-Germain 75006 Paris - France)
10
Service de Réanimation Néonatale et Pédiatrique (Paris - France)
- AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP) (France)
- CHU Necker - Enfants Malades [AP-HP] (149 Rue de Sèvres 75015 Paris - France)
Abstract : Sulfonylureas, widely used as hypoglycemic agents in adults with type 2 diabetes, have neuroprotective effects in preclinical models of central nervous system injury, and in children with neuropsychomotor impairments linked to neonatal diabetes secondary to ATP-sensitive potassium channel mutations. In the human and rodent retina, we show that the glibenclamide-activated channel sulfonylurea receptor 1 (SUR1) is expressed in the retina and enriched in the macula; we also show that it colocalizes with the potassium channel Kir6.2, and with the cation channel transporter TRPM4. Glibenclamide (glyburide), administered at doses that did not decrease the glycemia, or injected directly into the eye, protected the structure and the function of the retina in various models of retinal injury that recapitulate the pathogenic neurodegenerative events in the diabetic retina. The downregulation of SUR1 using a siRNA suppressed the neuroprotective effects of glibenclamide on excitotoxic stress-induced cell death. The glibenclamide effects include the transcriptional regulation of antioxidant and neuroprotective genes. Ocular glibenclamide could be repurposed for diabetic retinopathy.
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Journal articles
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https://www.hal.inserm.fr/inserm-02980520
Contributor : Emilie Picard <>
Submitted on : Tuesday, October 27, 2020 - 3:11:51 PM
Last modification on : Wednesday, June 23, 2021 - 11:04:18 AM
Long-term archiving on: : Thursday, January 28, 2021 - 7:08:24 PM
Contributor : Emilie Picard <>
Submitted on : Tuesday, October 27, 2020 - 3:11:51 PM
Last modification on : Wednesday, June 23, 2021 - 11:04:18 AM
Long-term archiving on: : Thursday, January 28, 2021 - 7:08:24 PM
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- HAL Id : inserm-02980520, version 1
- PUBMED : 33080394
- DOI : 10.1016/j.trsl.2020.10.003
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Citation
Marianne Berdugo, Kimberley Delaunay, Marie-Christine Naud, Justine Guegan, Alexandre Moulin, et al.. The antidiabetic drug glibenclamide exerts direct retinal neuroprotection: Glibenclamide exerts retinal neuroprotection. American Journal of Translational Research, E-Century Publishing Corporation, 2020, pp.S1931-5244(20)30244-9. ⟨10.1016/j.trsl.2020.10.003⟩. ⟨inserm-02980520⟩
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