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Journal articles
Going Platinum to the Tune of a Remarkable Guanine Quadruplex Binder: Solution‐ and Solid‐State Investigations.
Abstract : Guanine quadruplex recognition has gained increasing attention, inspired by the growing awareness of the key roles played by these non-canonical nucleic acid architectures in cellular regulatory processes. We report here the solution and solid-state studies of a novel planar platinum(II) complex that is easily assembled from a simple ligand, and exhibits notable binding affinity for guanine quadruplex structures, while maintaining good selectivity for guanine quadruplex over duplex structures. A crystal structure of this ligand complexed with a telomeric quadruplex confirms double end-capping, with dimerization at the 5' interface.
Cited literature [69 references]
https://www.hal.inserm.fr/inserm-02976985
Contributor : Jean-Louis Mergny <>
Submitted on : Friday, October 23, 2020 - 6:31:09 PM
Last modification on : Monday, December 7, 2020 - 9:44:02 AM
Contributor : Jean-Louis Mergny <>
Submitted on : Friday, October 23, 2020 - 6:31:09 PM
Last modification on : Monday, December 7, 2020 - 9:44:02 AM