Going Platinum to the Tune of a Remarkable Guanine Quadruplex Binder: Solution‐ and Solid‐State Investigations. - Archive ouverte HAL Access content directly
Journal Articles Angewandte Chemie International Edition Year : 2020

Going Platinum to the Tune of a Remarkable Guanine Quadruplex Binder: Solution‐ and Solid‐State Investigations.

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Abstract

Guanine quadruplex recognition has gained increasing attention, inspired by the growing awareness of the key roles played by these non-canonical nucleic acid architectures in cellular regulatory processes. We report here the solution and solid-state studies of a novel planar platinum(II) complex that is easily assembled from a simple ligand, and exhibits notable binding affinity for guanine quadruplex structures, while maintaining good selectivity for guanine quadruplex over duplex structures. A crystal structure of this ligand complexed with a telomeric quadruplex confirms double end-capping, with dimerization at the 5' interface.
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inserm-02976985 , version 1 (23-10-2020)

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Caitlin Miron, Laura van Staalduinen, Alana Rangaswamy, Mickey Chen, Yushi Liang, et al.. Going Platinum to the Tune of a Remarkable Guanine Quadruplex Binder: Solution‐ and Solid‐State Investigations.. Angewandte Chemie International Edition, 2020, Online ahead of print. ⟨10.1002/anie.202012520⟩. ⟨inserm-02976985⟩
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