D. Weerd, J. P. Greving, B. Hedblad, M. W. Lorenz, E. B. Mathiesen et al., Prevalence of asymptomatic carotid artery stenosis in the general population: an individual participant data meta-analysis, Stroke, vol.41, pp.1294-1301, 2010.

A. R. Naylor, J. B. Ricco, G. J. De-borst, S. Debus, J. De-haro et al., Management of atherosclerotic carotid and vertebral artery disease: 2017 clinical practice guidelines of the European Society for Vascular Surgery (ESVS), Eur J Vasc Endovasc Surg, vol.55, pp.3-81, 2018.

P. M. Rothwell, M. Eliasziw, S. A. Gutnikov, A. J. Fox, D. W. Taylor et al., Analysis of pooled data from the randomized controlled trials of endarterectomy for symptomatic carotid stenosis, Lancet, vol.361, pp.107-123, 2003.

, Executive committee for the Asymptomatic Carotid Atherosclerosis Study. Endarterectomy for asymptomatic carotid artery stenosis, JAMA, vol.273, pp.1421-1429, 1995.

A. Halliday, M. Harrison, E. Hayter, X. Kong, A. Mansfield et al., Asymptomatic Carotid Surgery Trial (ACST) Collaborative Group. 10-year stroke prevention after successful carotid endarterectomy for asymptomatic stenosis (ACST-1): a multicenter randomised trial, Lancet, vol.376, pp.1074-84, 2010.

A. R. Naylor, Time to rethink management strategies in asymptomatic carotid disease, Nat Rev Cardiol, vol.9, pp.116-140, 2012.

S. Chaturvedi, M. Chimowitz, R. D. Brown, B. K. Lal, and J. F. Meschia, The urgent need for contemporary clinical trials in patients with asymptomatic carotid stenosis, Neurology, vol.87, pp.2271-2279, 2016.

T. G. Brott, R. W. Hobson, G. Howard, G. S. Roubin, W. M. Clark et al., Stenting versus endarterectomy for treatment of carotid-artery stenosis, N Engl J Med, vol.363, pp.11-23, 2010.

K. Rosenfield, J. S. Matsumura, S. Chaturvedi, T. Riles, G. M. Ansel et al., ACT I Investigators. Randomized trial of stent versus surgery for asymptomatic carotid stenosis, N Engl J Med, vol.374, pp.1011-1031, 2016.

J. L. Mas, G. Chatellier, B. Beyssen, A. Branchereau, T. Moulin et al., EVA-3S Investigators. Endarterectomy versus stenting in patients with symptomatic severe carotid stenosis, N Engl J Med, vol.355, pp.1660-71, 2006.

J. L. Mas, C. Arquizan, D. Calvet, A. Viguier, J. F. Albucher et al., Long-term follow-up study of endarterectomy versus angio-plasty in patients with symptomatic severe carotid stenosis trial, Stroke, vol.45, pp.2750-2756, 2014.

G. Howard, G. S. Roubin, O. Jansen, J. Hendrikse, A. Halliday et al., Carotid Stenting Trialists' Collaboration. Association between age and risk of stroke or death from carotid endarterectomy and carotid stenting: a meta-analysis of pooled patient data from four randomised trials, Lancet, vol.387, pp.1305-1316, 2016.

P. Vikatmaa, D. Mitchell, L. P. Jensen, B. Beiles, M. Björck et al., Variation in clinical practice in carotid surgery in nine countries 2005-2010. Lessons from VASCUNET and recommendations for the future of national clinical audit, Eur J Vasc Endovasc Surg, vol.44, pp.11-18, 2012.

F. E. Wang, D. Esterbrooks, Y. F. Kuo, A. Mooss, S. M. Mohiuddin et al., Outcomes after carotid artery stenting and endarterectomy in the medicare population, Stroke, vol.42, pp.2019-2044, 2011.

A. L. Abbott, Medical (nonsurgical) intervention alone is now best for prevention of stroke associated with asymptomatic severe carotid stenosis: results of a systematic review and analysis, Stroke, vol.40, pp.573-83, 2009.

A. R. Naylor, What is the current status of invasive treatment of extracranial carotid artery disease?, Stroke, vol.42, pp.2080-2085, 2011.

P. M. Rothwell, Carotid stenting: more risky than endarterectomy and often no better than medical treatment alone, Lancet, vol.375, pp.957-966, 2010.

G. W. Van-lammeren, H. M. Den-ruijter, J. Vrijenhoek, M. D. Van-der-laan, E. Velema et al., Time-dependent changes in atherosclerotic plaque composition in patients undergoing carotid surgery, Circulation, vol.129, pp.2269-76, 2014.

J. H. Lichtman, M. R. Jones, E. C. Leifheit, A. J. Sheffet, G. Howard et al., Carotid endarterectomy and carotid artery stenting in the US Medicare population, JAMA, vol.318, pp.1035-1081, 1999.

D. G. Hackam and J. D. Spence, Decline in the severity of carotid atherosclerosis and associated risk factors from, Stroke, vol.49, pp.2786-2794, 2002.

K. Paraskevas, E. Kalmykov, and A. R. Naylor, Stroke/death rates following carotid artery stenting and carotid endarterectomy in contemporary administrative dataset registries: a systematic review, Eur J Vasc Endovasc Surg, vol.51, pp.3-12, 2016.

G. A. Antoniou, S. Hajibandeh, S. Hajibandeh, S. R. Vallabhaneni, J. A. Brennan et al., Meta-analysis of the effects of statins on perioperative outcomes in vascular and endovascular surgery, J Vasc Surg, vol.61, pp.519-551, 2015.

S. K. Kakkos, A. N. Nicolaides, I. Charalambous, D. Thomas, A. Giannopoulos et al., Predictors and clinical significance of progression or regression of asymptomatic carotid stenosis, J Vasc Surg, vol.59, pp.956-67, 2014.

L. S. Hirt, Progression rate and ipsilateral neurological events in asymptomatic carotid stenosis, Stroke, vol.45, pp.702-708, 2014.

A. Gupta, K. Kesavabhotla, H. Baradaran, H. Kamel, A. Pandya et al., Plaque echolucency and stroke risk in asymptomatic carotid stenosis: a systematic review and metaanalysis, Stroke, vol.46, pp.91-98, 2015.

H. S. Markus, A. King, M. Shipley, R. Topakian, M. Cullinane et al., Asymptomatic embolisation for prediction of stroke in the asymptomatic carotid emboli study: a prospective observational study, Lancet Neurol, vol.9, pp.663-71, 2010.

R. Topakian, A. King, U. Kwon, A. Schaafsma, M. Shipley et al., Ultrasonic plaque echolucency and emboli signals predict stroke in asymptomatic carotid stenosis, Neurology, vol.77, pp.751-759, 2011.

A. Nicolaides, S. K. Kakkos, E. Kyriacou, M. Griffin, D. J. Thomas et al., Asymptomatic internal carotid artery stenosis and cerebrovascular risk stratification, J Vasc Surg, vol.52, pp.1486-96, 2010.

S. K. Kakkos, M. B. Griffin, A. N. Nicolaides, E. Kyriacou, M. M. Sabetai et al., The size of the juxta-luminal hypoechoic area in ultrasound images of asymptomatic carotid plaques predicts the occurrence of stroke, J Vasc Surg, vol.57, pp.609-627, 2013.

A. Gupta, H. Baradaran, A. D. Schweitzer, H. Kamel, A. Pandya et al., Carotid plaque MRI and stroke risk: a systematic review and meta-analysis, Stroke, vol.44, pp.3071-3078, 2013.

A. King, J. Serena, N. M. Bornstein, and H. M. Markus, On behalf of the ACES Investigators. Does impaired cerebrovascular reactivity predict stroke risk in asymptomatic carotid stenosis: a prospective substudy of the asymptomatic carotid emboli study, Stroke, vol.42, pp.1550-1555, 2011.

S. K. Kakkos, M. Sabetai, T. Tegos, J. Stevens, D. Thomas et al., Silent embolic infarcts on computed tomography brain scans and risk of ipsilateral hemispheric events in patients with asymptomatic internal carotid artery stenosis, J Vasc Surg, vol.49, pp.902-911, 2009.

A. N. Nicolaides, S. K. Kakkos, M. Griffin, M. Sabetai, S. Dhanjil et al., Severity of asymptomatic carotid stenosis and risk of ipsilateral hemispheric ischaemic events: results from ACSRS, Eur J Vasc Endovasc Surg, vol.30, pp.275-84, 2005.

J. B. Wallaert, J. L. Cronenwett, D. J. Bertges, A. Schanzer, B. W. Nolan et al., Optimal selection of asymptomatic patients for carotid endarterectomy based on predicted 5-year survival, J Vasc Surg, vol.58, pp.112-120, 2013.

S. Keyhani, E. Madden, E. M. Cheng, D. M. Bravata, E. Halm et al., Risk prediction tools to improve patient selection for carotid endarterectomy among patients with asymptomatic carotid stenosis, JAMA Surg, 2019.

H. S. Gurm, J. S. Yadav, P. Fayad, B. T. Katzen, G. J. Mishkel et al., Long-term results of carotid stenting versus endarterectomy in high-risk patients, NEJM, vol.358, pp.1572-1581, 2008.

H. H. Eckstein, T. Reiff, P. Ringleb, O. Jansen, U. Mansmann et al., SPACE-2 investigators. SPACE-2: a missed opportunity to compare carotid endarterectomy, carotid stenting, and best medical treatment in patients with asymptomatic carotid stenoses, Eur J Vasc Endovasc Surg, vol.51, pp.761-766, 2016.

V. Aboyans, J. B. Ricco, M. Bartelink, M. Björck, M. Brodmann et al., ESC Scientific Document Group. 2017 ESC guidelines on the diagnosis and treatment of peripheral arterial diseases, in collaboration with the European Society for Vascular Surgery (ESVS), Eur Heart J, vol.39, pp.763-816, 2018.