B. Nelson, P. D. Mcgorry, M. Wichers, J. Wigman, and J. A. Hartmann, Moving From Static to Dynamic Models of the Onset of Mental Disorder: A Review, JAMA Psychiatry, vol.74, issue.5, p.528, 2017.

O. D. Howes and R. M. Murray, Schizophrenia: An Integrated Sociodevelopmental-Cognitive Model, Lancet, vol.383, issue.13, p.62036, 2014.

P. Fusar-poli, S. Borgwardt, A. Bechdolf, J. Addington, A. Riecher-rössler et al., The Psychosis High-Risk State: A Comprehensive State-of-the-Art Review, JAMA Psychiatry, vol.70, issue.1, p.107, 2013.

O. Kebir, B. Chaumette, F. Rivollier, F. Miozzo, L. Perreault et al., Methylomic Changes during Conversion to Psychosis, Mol Psychiatry, vol.22, issue.4, pp.512-530, 2017.
URL : https://hal.archives-ouvertes.fr/hal-02929950

B. Chaumette, O. Kebir, J. Pouch, B. Ducos, and F. Selimi, Longitudinal Analyses of Blood Transcriptome During Conversion to Psychosis, Schizophr Bull, vol.45, issue.1, pp.247-55, 2019.

B. Chaumette, O. Kebir, C. Mam-lam-fook, Y. Morvan, J. Bourgin et al., Salivary Cortisol in Early Psychosis: New Findings and Meta-Analysis
URL : https://hal.archives-ouvertes.fr/hal-01312810

, Psychoneuroendocrinology, vol.63, pp.262-70, 2016.

L. Girshkin, S. L. Matheson, A. M. Shepherd, and M. J. Green, Morning Cortisol Levels in Schizophrenia and Bipolar Disorder: A Meta-Analysis, Psychoneuroendocrinology, vol.49, pp.187-206, 2014.

M. Berger, A. K. Kraeuter, D. Romanik, P. Malouf, G. P. Amminger et al., Cortisol Awakening Response in Patients with Psychosis: Systematic Review and Meta-Analysis, Neurosci Biobehav Rev, vol.68, pp.157-66, 2016.

M. Pruessner, L. Béchard-evans, L. Boekestyn, S. N. Iyer, J. C. Pruessner et al., Attenuated Cortisol Response to Acute Psychosocial Stress in Individuals at Ultra-High Risk for Psychosis, Schizophr Res, vol.146, pp.79-86, 2013.

E. F. Walker, H. D. Trotman, B. D. Pearce, J. Addington, K. S. Cadenhead et al., Cortisol Levels and Risk for Psychosis: Initial Findings From the North American Prodrome Longitudinal Study, Biol Psychiatry, vol.74, issue.6, pp.410-417, 2013.

M. Pruessner, N. Vracotas, R. Joober, J. C. Pruessner, and A. K. Malla, Blunted Cortisol Awakening Response in Men with First Episode Psychosis: Relationship to Parental Bonding, Psychoneuroendocrinology, vol.38, pp.229-269, 2013.

E. E. Carol, R. L. Spencer, and V. A. Mittal, Sex Differences in Morning Cortisol in Youth at Ultra-High-Risk for Psychosis, Psychoneuroendocrinology, vol.72, pp.87-93, 2016.

I. Jaric, D. Rocks, H. Cham, A. Herchek, and M. Kundakovic, Sex and Estrous Cycle Effects on Anxiety-and Depression-Related Phenotypes in a Two-Hit Developmental Stress Model, Front Mol Neurosci, vol.12, p.74, 2019.

C. H. Bourke, M. Q. Raees, S. Malviya, C. A. Bradburn, E. B. Binder et al., Glucocorticoid Sensitizers Bag1 and Ppid Are Regulated by Adolescent Stress in a Sex-Dependent Manner, Psychoneuroendocrinology, vol.38, pp.84-93, 2013.

J. Hill, A. Pickles, N. Wright, J. P. Quinn, C. Murgatroyd et al., Mismatched Prenatal and Postnatal Maternal Depressive Symptoms and Child Behaviours: A Sex-Dependent Role for NR3C1 DNA Methylation in the Wirral Child Health and Development Study, Cells, vol.8, p.943, 2019.

N. Sarubin, S. Hilbert, F. Naumann, P. Zill, A. M. Wimmer et al., The Sex-Dependent Role of the Glucocorticoid Receptor in Depression: Variations in the NR3C1 Gene Are Associated with Major Depressive Disorder in Women but Not in Men, Eur Arch Psychiatry Clin Neurosci, vol.267, pp.123-156, 2017.

R. Kumsta, S. Entringer, J. W. Koper, E. Van-rossum, D. H. Hellhammer et al., Sex Specific Associations between Common Glucocorticoid Receptor Gene Variants and Hypothalamus-Pituitary-Adrenal Axis Responses to Psychosocial Stress, Biol Psychiatry, vol.62, pp.863-69, 2007.

D. Sinclair, J. M. Fullerton, M. J. Webster, and C. S. Weickert, Glucocorticoid Receptor 1B and 1C MRNA Transcript Alterations in Schizophrenia and Bipolar Disorder, and Their Possible Regulation by GR Gene Variants, PloS One, vol.7, p.31720, 2012.

A. F. Schatzberg, J. Keller, L. Tennakoon, A. Lembke, G. Williams et al., HPA Axis Genetic Variation, Cortisol and Psychosis in Major Depression, Mol Psychiatry, vol.19, pp.220-247, 2014.

J. Keller, R. Gomez, G. Williams, A. Lembke, L. Lazzeroni et al., HPA Axis in Major Depression: Cortisol, Clinical Symptomatology and Genetic Variation Predict Cognition, Mol Psychiatry, vol.22, pp.527-563, 2017.

D. Smith, G. Ebrahim, and S. , Mendelian Randomization': Can Genetic Epidemiology Contribute to Understanding Environmental Determinants of Disease?, Int J Epidemiol, vol.32, pp.1-22, 2003.

Z. Zhu, F. Zhang, H. Hu, A. Bakshi, M. R. Robinson et al., Integration of Summary Data from GWAS and EQTL Studies Predicts Complex Trait Gene Targets, Nat Genet, vol.48, pp.481-87, 2016.

A. Oppetit, J. Bourgin, G. Martinez, M. Kazes, C. Mam-lam-fook et al., The C'JAAD: A French Team for Early Intervention in Psychosis in Paris: An Early Intervention Team in Paris, Early Interv Psychiatry, vol.12, pp.243-292, 2018.

A. R. Yung, H. P. Yuen, P. D. Mcgorry, L. J. Phillips, D. Kelly et al., Mapping the Onset of Psychosis: The Comprehensive Assessment of At-Risk Mental States, Aust N Z J Psychiatry, vol.39, pp.964-71, 2005.

M. O. Krebs, E. Magaud, D. Willard, C. Elkhazen, F. Chauchot et al., Évaluation des états mentaux à risque de transition psychotique : validation de la version française de la CAARMS, vol.40, pp.447-56, 2014.

P. D. Mcgorry, R. Purcell, I. B. Hickie, A. R. Yung, C. Pantelis et al., Clinical staging: a heuristic model for psychiatry and youth mental health, Med J Aust, vol.187, issue.S7, pp.40-42, 2007.

R. A. Dressendörfer, C. Kirschbaum, W. Rohde, F. Stahl, and C. J. Strasburger, Synthesis of a Cortisol-Biotin Conjugate and Evaluation as a Tracer in an Immunoassay for Salivary Cortisol Measurement, J Steroid Biochem Mol Biol, vol.43, pp.683-92, 1992.

K. J. Livak and T. D. Schmittgen, Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2-DDCT Method, Methods, vol.25, pp.402-410, 2001.

T. Hruz, M. Wyss, M. Docquier, M. W. Pfaffl, S. Masanetz et al., RefGenes: identification of reliable and condition specific reference genes for RT-qPCR data normalization, BMC Genomics, vol.12, p.156, 2011.

C. C. Chang, C. C. Chow, L. Tellier, S. Vattikuti, S. M. Purcell et al., Second-Generation PLINK: Rising to the Challenge of Larger and Richer Datasets, GigaScience, vol.4, p.7, 2015.

Y. J. Trakadis, V. Fulginiti, and M. Walterfang, Inborn errors of metabolism associated with psychosis: literature review and case-control study using exome data from 5090 adult individuals, J Inherit Metab Dis, vol.41, pp.613-634, 2018.

W. E. Swinehart and J. E. Jackman, Diversity in Mechanism and Function of TRNA Methyltransferases, RNA Biol, vol.12, pp.398-411, 2015.

S. Blanco, S. Dietmann, J. V. Flores, S. Hussain, C. Kutter et al., Aberrant Methylation of t RNA s Links Cellular Stress to Neurodevelopmental Disorders, EMBO J, vol.33, pp.2020-2059, 2014.

T. Kozuka, Y. Omori, S. Watanabe, E. Tarusawa, H. Yamamoto et al., MiR-124 Dosage Regulates Prefrontal Cortex Function by Dopaminergic Modulation, Sci Rep, vol.9, p.3445, 2019.

S. Bandres-ciga, A. J. Noyce, and B. J. Traynor, Mendelian Randomization-A Journey From Obscurity to Center Stage With a Few Potholes Along the Way, JAMA Neurol, vol.77, issue.1, pp.7-8, 2019.

H. Palma-gudiel, A. Córdova-palomera, C. Tornador, C. Falcón, N. Bargalló et al., Increased Methylation at an Unexplored Glucocorticoid Responsive Element within Exon 1 D of NR3C1 Gene Is Related to Anxious-Depressive Disorders and Decreased Hippocampal Connectivity, Eur Neuropsychopharmacol, vol.28, pp.579-88, 2018.

D. S. Tylee, D. M. Kawaguchi, and S. J. Glatt, On the Outside, Looking in: A Review and Evaluation of the Comparability of Blood and Brain '-Omes, Am J Med Genet B Neuropsychiatr Genet, vol.162, pp.595-603, 2013.