Different profiles of body mass index variation among patients with multidrug-resistant tuberculosis: a retrospective cohort study - Archive ouverte HAL Access content directly
Journal Articles BMC Infectious Diseases Year : 2020

Different profiles of body mass index variation among patients with multidrug-resistant tuberculosis: a retrospective cohort study

(1, 2) , (3) , (3) , (3) , (4) , (5) , (6) , (7) , (3)
1
2
3
4
5
6
7

Abstract

Background: Despite the predictive role of body weight variation in treatment outcome in multidrug-resistant tuberculosis (MDR-TB), few corroborating data are available. We studied weight variation in patients with MDR-TB to identify groups of weight change and to determine factors that influence these changes. Methods: We analyzed patients with rifampicin resistance who were treated with an MDR-TB treatment regimen between June 07, 2016 and June 22, 2018 at three major drug-resistant TB centers in Guinea. Patients were seen monthly until the end of treatment. Clinical outcome was the body mass index (BMI). We used a linear mixed model to analyze trajectories of BMI and a latent class mixed model to identify groups of BMI trajectories. Results: Of 232 patients treated for MDR-TB during the study period, 165 were analyzed. These patients had a total of 1387 visits, with a median of 5 visits (interquartile range, 3-8 visits). Monthly BMI increase was 0.24 (SE 0.02) per kg/m2. Factors associated with faster BMI progression were success of MDR-TB treatment (0.24 [SE 0.09] per kg/m2; p = 0.0205) and absence of lung cavities on X-ray (0.18 [0.06] per kg/m2; p = 0.0068). Two groups of BMI change were identified: rapid BMI increase (n = 121; 85%) and slow BMI increase (n = 22; 15%). Patients in the slow BMI increase group were mostly female (68%) had no history of TB treatment (41%), had a positive HIV infection (59%), and had a more severe clinical condition at baseline, characterized by a higher frequency of symptoms including depression (18%), dyspnea (68%), poor adherence to MDR-TB treatment (64%), lower platelet count, and higher SGOT. These patients also had a longer time to initial culture conversion (log-rank test: p = 0.0218). Conclusion: Quantitative BMI data on patients with MDR-TB treated with a short regimen allowed the identification of subgroups of patients with different trajectories of BMI and emphasized the usefulness of BMI as a biomarker for the monitoring of MDR-TB treatment outcome
Fichier principal
Vignette du fichier
s12879-020-05028-0.pdf (1.36 Mo) Télécharger le fichier
Origin : Publication funded by an institution
Loading...

Dates and versions

inserm-02968876 , version 1 (16-10-2020)

Identifiers

Cite

Alhassane Diallo, Boubacar Djelo Diallo, Lansana Mady Camara, Lucrèce Ahouéfa Nadège Kounoudji, Boubacar Bah, et al.. Different profiles of body mass index variation among patients with multidrug-resistant tuberculosis: a retrospective cohort study. BMC Infectious Diseases, 2020, 20 (1), pp.315. ⟨10.1186/s12879-020-05028-0⟩. ⟨inserm-02968876⟩
74 View
83 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More