Integrated microbiota and metabolite profiles link Crohn’s disease to sulfur metabolism - Inserm - Institut national de la santé et de la recherche médicale Accéder directement au contenu
Article Dans Une Revue Nature Communications Année : 2020

Integrated microbiota and metabolite profiles link Crohn’s disease to sulfur metabolism

Résumé

Gut microbial and metabolite alterations have been linked to the pathogenesis of inflammatory bowel diseases. Here we perform a multi-omics microbiome and metabolite analysis of a longitudinal cohort of Crohn's disease patients undergoing autologous hematopoietic stem cell transplantation, and investigational therapy that induces drug free remission in a subset of patients. Via comparison of patients who responded and maintained remission, responded but experienced disease relapse and patients who did not respond to therapy, we identify shared functional signatures that correlate with disease activity despite the variability of gut microbiota profiles at taxonomic level. These signatures reflect the disease state when transferred to gnotobiotic mice. Taken together, the integration of microbiome and metabolite profiles from human cohort and mice improves the predictive modelling of disease outcome, and allows the identification of a network of bacteria-metabolite interactions involving sulfur metabolism as a key mechanism linked to disease activity in Crohn's disease.
Fichier principal
Vignette du fichier
s41467-020-17956-1.pdf (7.63 Mo) Télécharger le fichier
Origine : Publication financée par une institution
Loading...

Dates et versions

inserm-02955923 , version 1 (02-10-2020)

Identifiants

Citer

Amira Metwaly, Andreas Dunkel, Nadine Waldschmitt, Abilash Chakravarthy Durai Raj, Ilias Lagkouvardos, et al.. Integrated microbiota and metabolite profiles link Crohn’s disease to sulfur metabolism. Nature Communications, 2020, 11 (1), pp.4322. ⟨10.1038/s41467-020-17956-1⟩. ⟨inserm-02955923⟩

Collections

INSERM UP-SANTE
112 Consultations
143 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More