F. Bray, J. Ferlay, I. Soerjomataram, R. L. Siegel, L. A. Torre et al., Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries, CA Cancer J. Clin, vol.68, pp.394-424, 2018.

R. L. Siegel, K. D. Miller, and A. Jemal, CA Cancer J. Clin, vol.68, pp.7-30, 2018.

G. J. Riely, M. G. Kris, D. Rosenbaum, J. Marks, A. Li et al., Frequency and distinctive spectrum of KRAS mutations in never smokers with lung adenocarcinoma, Clin. Cancer Res, vol.14, pp.5731-5734, 2008.

A. E. Karnoub and R. A. Weinberg, Ras oncogenes: split personalities, Nat. Rev. Mol. Cell Biol, vol.9, pp.517-531, 2008.

G. J. Riely and M. Ladanyi, KRAS mutations: an old oncogene becomes a new predictive biomarker, J. Mol. Diagn, vol.10, pp.493-495, 2008.

C. Tan and X. Du, KRAS mutation testing in metastatic colorectal cancer, World J. Gastroenterol, vol.18, pp.5171-5180, 2012.

A. M. Krasinskas, S. I. Chiosea, T. Pal, and S. Dacic, KRAS mutational analysis and immunohistochemical studies can help distinguish pancreatic metastases from primary lung adenocarcinomas, Mod. Pathol, vol.27, pp.262-270, 2014.

A. D. Cox, S. W. Fesik, A. C. Kimmelman, J. Luo, and C. J. Der, Drugging the undruggable RAS: Mission possible?, Nat. Rev. Drug Discov, vol.13, pp.828-851, 2014.

H. Ying, A. C. Kimmelman, C. A. Lyssiotis, S. Hua, G. C. Chu et al., Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism, Cell, vol.149, pp.656-670, 2012.

M. H. Yang, S. Nickerson, E. T. Kim, C. Liot, G. Laurent et al., Regulation of RAS oncogenicity by acetylation, vol.109, pp.10843-10848, 2012.

T. Maurer, L. S. Garrenton, A. Oh, K. Pitts, D. J. Anderson et al., Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity, vol.109, pp.5299-5304, 2012.

B. Bournet, C. Buscail, F. Muscari, P. Cordelier, and L. Buscail, Targeting KRAS for diagnosis, prognosis, and treatment of pancreatic cancer: Hopes and realities, Eur. J. Cancer, vol.54, pp.75-83, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01278606

M. B. Ryan and R. B. Corcoran, Therapeutic strategies to target RAS-mutant cancers, Nat. Rev. Clin. Oncol, vol.15, pp.709-720, 2018.

C. Xie, Y. Li, L. L. Li, X. X. Fan, Y. W. Wang et al., Identification of a new potent inhibitor targeting KRAS in non-small cell lung cancer cells, Front. Pharmacol, vol.8, p.823, 2017.

Q. Sun, J. P. Burke, J. Phan, M. C. Burns, E. T. Olejniczak et al., Discovery of small molecules that bind to K-Ras and inhibit Sos-mediated activation, Angew. Chem, vol.51, pp.6140-6143, 2012.

E. L. Leung, L. X. Luo, Z. Q. Liu, V. K. Wong, L. L. Lu et al., Inhibition of KRAS-dependent lung cancer cell growth by deltarasin: blockage of autophagy increases its cytotoxicity, Cell Death. Dis, vol.9, p.216, 2018.

A. D. Cox, C. J. Der, and M. R. Philips, Targeting RAS membrane association: back to the future for anti-RAS drug discovery?, Clin. Cancer Res, vol.21, pp.1819-1827, 2015.

E. Pupo, D. Avanzato, E. Middonti, F. Bussolino, and L. Lanzetti, KRAS-driven metabolic rewiring reveals novel actionable targets in cancer, Front. Oncol, vol.9, p.848, 2019.

W. Kim, S. Lee, H. S. Kim, M. Song, Y. H. Cha et al., Targeting mutant KRAS with CRISPR-Cas9 controls tumor growth, Genome Res, vol.28, pp.374-382, 2018.

A. Bedrat, L. Lacroix, and J. L. Mergny, Re-evaluation of G-quadruplex propensity with G4Hunter, Nucleic Acids Res, vol.44, pp.1746-1759, 2016.

H. M. Wong, O. Stegle, S. Rodgers, and J. L. Huppert, A toolbox for predicting g-quadruplex formation and stability, J. Nucleic Acids, p.564946, 2010.

Y. Sannohe and H. Sugiyama, Overview of formation of G-quadruplex structures, Curr. Protoc. Nucleic Acid Chem, 2010.

O. Stegle, L. Payet, J. L. Mergny, D. J. Mackay, and J. H. Leon, Predicting and understanding the stability of G-quadruplexes, 2009.

, Bioinformatics, vol.25, pp.374-382

R. Tippana, W. Xiao, and S. Myong, G-quadruplex conformation and dynamics are determined by loop length and sequence, Nucleic Acids Res, vol.42, pp.8106-8114, 2014.

X. Cang, J. Sponer, and T. E. Cheatham, Explaining the varied glycosidic conformational, G-tract length and sequence preferences for anti-parallel G-quadruplexes, Nucleic Acids Res, vol.39, pp.4499-4512, 2011.

H. T. Le, W. L. Dean, R. Buscaglia, J. B. Chaires, and J. O. Trent, An investigation of G-quadruplex structural polymorphism in the human telomere using a combined approach of hydrodynamic bead modeling and molecular dynamics simulation, J. Phys. Chem. B, vol.118, pp.5390-5405, 2014.

J. Dai, M. Carver, and D. Yang, Polymorphism of human telomeric quadruplex structures, Biochimie, vol.90, pp.1172-1183, 2008.

M. L. Bochman, K. Paeschke, and V. A. Zakian, DNA secondary structures: stability and function of G-quadruplex structures, Nat. Rev. Genet, vol.13, pp.770-780, 2012.

H. J. Lipps and D. Rhodes, G-quadruplex structures: in vivo evidence and function, Trends Cell Biol, vol.19, pp.414-422, 2009.

J. Gomez-marquez, DNA G-quadruplex: structure, function and human disease, FEBS J, vol.277, p.3451, 2010.

J. Amato, T. W. Madanayake, N. Iaccarino, E. Novellino, A. Randazzo et al., HMGB1 binds to the KRAS promoter G-quadruplex: a new player in oncogene transcriptional regulation?, Chem. Commun, vol.54, pp.9442-9445, 2018.

S. Cogoi, V. Rapozzi, S. Cauci, and L. E. Xodo, Critical role of hnRNP A1 in activating KRAS transcription in pancreatic cancer cells: a molecular mechanism involving G4 DNA, Biochim. Biophys. Acta Gen. Subj, vol.1861, pp.1389-1398, 2017.

J. Carvalho, E. Pereira, J. Marquevielle, M. P. Campello, J. L. Mergny et al., Fluorescent light-up acridine orange derivatives bind and stabilize KRAS-22RT G-quadruplex, Biochimie, vol.144, pp.144-152, 2018.

S. Neidle, The structures of quadruplex nucleic acids and their drug complexes, Curr. Opin. Struct. Biol, vol.19, pp.239-250, 2009.

S. Cogoi, M. Paramasivam, V. Filichev, I. Geci, E. B. Pedersen et al., Identification of a new G-quadruplex motif in the KRAS promoter and design of pyrene-modified G4-decoys with antiproliferative activity in pancreatic cancer cells, J. Med. Chem, vol.52, pp.564-568, 2009.

R. Pattanayak, P. Basak, S. Sen, and M. Bhattacharyya, Interaction of KRAS G-quadruplex with natural polyphenols: a spectroscopic analysis with molecular modeling, Int. J. Biol. Macromol, vol.89, pp.228-237, 2016.

, Nucleic Acids Research, vol.48, issue.16, p.9345, 2020.

V. Sklenar, T. Dieckmann, S. E. Butcher, and J. Feigon, Through-bond correlation of imino and aromatic resonances in 13C-, 15N-labeled RNA via heteronuclear TOCSY, J. Biomol. NMR, vol.7, pp.83-87, 1996.

V. Sklenar, J. E. Masse, and J. Feigon, HCCCH experiment for through-bond correlation of thymine resonances in 13C-labeled DNA oligonucleotides, J. Magn. Reson, vol.137, pp.345-349, 1999.

A. T. Brunger, P. D. Adams, G. M. Clore, W. L. Delano, P. Gros et al., Crystallography & NMR system: A new software suite for macromolecular structure determination, Acta crystallog D, Biol Crystallogr, vol.54, pp.905-921, 1998.

A. T. Brunger, Version 1.2 of the crystallography and NMR system, Nat. Protoc, vol.2, pp.2728-2733, 2007.

A. Randazzo, G. P. Spada, and M. W. Da-silva, Circular dichroism of quadruplex structures, Top. Curr. Chem, vol.330, pp.67-86, 2013.

M. Vorlickova, I. Kejnovska, K. Bednarova, D. Renciuk, and J. Kypr, Circular dichroism spectroscopy of DNA: from duplexes to quadruplexes, Chirality, vol.24, pp.691-698, 2012.

M. Webba-da-silva, NMR methods for studying quadruplex nucleic acids, Methods, vol.43, pp.264-277, 2007.

S. Cogoi, M. Paramasivam, B. Spolaore, and L. E. Xodo, Structural polymorphism within a regulatory element of the human KRAS promoter: formation of G4-DNA recognized by nuclear proteins, Nucleic Acids Res, vol.36, pp.3765-3780, 2008.

S. Cogoi and L. E. Xodo, G-quadruplex formation within the promoter of the KRAS proto-oncogene and its effect on transcription, Nucleic Acids Res, vol.34, pp.2536-2549, 2006.

A. T. Phan, V. Kuryavyi, H. Y. Gaw, and D. J. Patel, Small-molecule interaction with a five-guanine-tract G-quadruplex structure from the human MYC promoter, Nat. Chem. Biol, vol.1, pp.167-173, 2005.

P. Sengupta, S. Chattopadhyay, and S. Chatterjee, , 2017.

G. , Quadruplex surveillance in BCL-2 gene: a promising therapeutic intervention in cancer treatment, Drug Discov. Today, vol.22, pp.1165-1186

A. P. Francisco and A. Paulo, Oncogene expression modulation in cancer cell lines by DNA G-Quadruplex-Interactive small molecules, Curr. Med. Chem, vol.24, pp.4873-4904, 2017.

S. Asamitsu, S. Obata, Z. Yu, T. Bando, and H. Sugiyama, Recent progress of targeted G-Quadruplex-Preferred ligands toward cancer therapy, Molecules, p.24, 2019.

R. Hansel-hertsch, D. Beraldi, S. V. Lensing, G. Marsico, K. Zyner et al., , 2016.

, G-quadruplex structures mark human regulatory chromatin, Nat. Genet, vol.48, pp.1267-1272

M. Paramasivam, S. Cogoi, and L. E. Xodo, Primer extension reactions as a tool to uncover folding motifs within complex G-rich sequences: analysis of the human KRAS NHE, Chem. Commun. (Camb.), vol.47, pp.4965-4967, 2011.

P. Podbevsek and J. Plavec, KRAS promoter oligonucleotide with decoy activity dimerizes into a unique topology consisting of two G-quadruplex units, Nucleic Acids Res, vol.44, pp.917-925, 2016.

S. Cogoi, S. Zorzet, V. Rapozzi, I. Geci, E. B. Pedersen et al., MAZ-binding G4-decoy with locked nucleic acid and twisted intercalating nucleic acid modifications suppresses KRAS in pancreatic cancer cells and delays tumor growth in mice, Nucleic Acids Res, vol.41, pp.4049-4064, 2013.

A. T. Phan, V. Kuryavyi, H. Y. Gaw, and D. J. Patel, Small-molecule interaction with a five-guanine-tract G-quadruplex structure from the human MYC promoter, Nat. Chem. Biol, vol.1, pp.67-173, 2005.