, PE/Cy5 anti-mouse CD127 (IL-7Ralpha) (A7R34) (1/100) Biolegend, p.135016
5 anti-mouse CD25 (PC61) (1/100) Biolegend 102029 ,
, Brilliant Violet 605 anti-mouse CD69 (HI-2F3) (1/100) Biolegend 104530 PE anti-mouse CD11c (N418) (1/100) Biolegend 117308
, PerCP-eFluor 710 anti-mouse CD170 (Siglec-F) (IRNM44N) (1/100) eBioscience, pp.46-1702
, Alexa Fluor 700 anti-mouse IFN-? (XMG1.2) (1/100) BD, Biosciences, vol.557998
, , vol.5
Low-grade inflammation, obesity, and diabetes, Curr. Obes. Rep, vol.3, pp.422-431, 2014. ,
Inflammatory mechanisms in obesity, Annu. Rev. Immunol, vol.29, pp.415-445, 2011. ,
Type 2 diabetes as an inflammatory disease, Nat. Rev. Immunol, vol.11, pp.98-107, 2011. ,
Local proliferation of macrophages contributes to obesityassociated adipose tissue inflammation, Cell Metab, vol.19, pp.162-171, 2014. ,
Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance, Science, vol.259, pp.87-91, 1993. ,
Identification of adipose tissue dendritic cells correlated with obesity-associated insulin-resistance and inducing Th17 responses in mice and patients, Diabetes, vol.61, pp.2238-2247, 2012. ,
URL : https://hal.archives-ouvertes.fr/inserm-00726176
Adipose tissue as an immunological organ, Obesity, vol.23, pp.512-518, 2015. ,
CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity, Nat. Med, vol.15, pp.914-920, 2009. ,
Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase, Nat. Med, vol.18, pp.1407-1412, 2012. ,
NK cells link obesity-induced adipose stress to inflammation and insulin resistance, Nat. Immunol, vol.16, pp.376-385, 2015. ,
Adipose natural killer cells regulate adipose tissue macrophages to promote insulin resistance in obesity, Cell Metab, vol.23, pp.685-698, 2016. ,
Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages, J. Exp. Med, vol.210, pp.535-549, 2013. ,
Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis, Science, vol.332, pp.243-247, 2011. ,
Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters, Nat. Med, vol.15, pp.930-939, 2009. ,
Macrophages, immunity, and metabolic disease, Immunity, vol.41, pp.36-48, 2014. ,
PPAR-gamma is a major driver of the accumulation and phenotype of adipose tissue Treg cells, Nature, vol.486, pp.549-553, 2012. ,
The effect of diet on the human gut microbiome: a metagenomic analysis in humanized gnotobiotic mice, Sci. Transl. Med, vol.1, pp.6-14, 2009. ,
Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43, Nature, vol.461, pp.1282-1286, 2009. ,
Diet, gut microbiota and immune responses, Nat. Immunol, vol.12, pp.5-9, 2011. ,
Mucosal-associated invariant T cells and disease, Nature Rev. Immunol, vol.19, pp.643-657, 2019. ,
URL : https://hal.archives-ouvertes.fr/inserm-02380171
Regulation of obesity-related insulin resistance with gut antiinflammatory agents, Cell Metab, vol.21, pp.527-542, 2015. ,
Jejunal T cell inflammation in human obesity correlates with decreased enterocyte insulin signaling, Cell Metab, vol.22, pp.113-124, 2015. ,
URL : https://hal.archives-ouvertes.fr/hal-02540998
The gut microbiota regulates intestinal CD4 T cells expressing RORgammat and controls metabolic disease, Cell Metab, vol.22, pp.100-112, 2015. ,
The intestinal immune system in obesity and insulin resistance, Cell Metab, vol.23, pp.413-426, 2016. ,
Gut microbiota modulation with norfloxacin and ampicillin enhances glucose tolerance in mice, FASEB J, vol.22, pp.2416-2426, 2008. ,
URL : https://hal.archives-ouvertes.fr/inserm-00409179
Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41. Proc. Natl Acad. Sci. USA 105, pp.16767-16772, 2008. ,
An obesity-associated gut microbiome with increased capacity for energy harvest, Nature, vol.444, pp.1027-1031, 2006. ,
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity, Nature, vol.482, pp.179-185, 2012. ,
Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1, Nature, vol.422, pp.164-169, 2003. ,
Analysis of T cell antigen receptor (TCR) expression by human peripheral blood CD4-8-alpha/ beta T cells demonstrates preferential use of several V beta genes and an invariant TCR alpha chain, J. Exp. Med, vol.178, pp.1-16, 1993. ,
MHC class I-related molecule, MR1, and mucosalassociated invariant T cells, Immunol. Rev, vol.272, pp.120-138, 2016. ,
Antimicrobial activity of mucosal-associated invariant T cells, Nat. Immunol, vol.11, pp.701-708, 2010. ,
URL : https://hal.archives-ouvertes.fr/hal-00550333
T-cell activation by transitory neo-antigens derived from distinct microbial pathways, Nature, vol.509, pp.361-365, 2014. ,
MR1 presents microbial vitamin B metabolites to MAIT cells, Nature, vol.491, pp.717-723, 2012. ,
Altered distribution and increased IL-17 production by mucosal-associated invariant T cells in adult and childhood obesity, J. Immunol, vol.194, pp.5775-5780, 2015. ,
Mucosal-associated invariant T cell alterations in obese and type 2 diabetic patients, J. Clin. Investig, vol.125, pp.1752-1762, 2015. ,
Activation-induced cell death of mucosal-associated invariant T cells is amplified by OX40 in type 2 diabetic patients, J. Immunol, vol.203, pp.2614-2620, 2019. ,
Identification of phenotypically and functionally heterogeneous mouse mucosal-associated invariant T cells using MR1 tetramers, J. Exp. Med, vol.212, pp.1095-1108, 2015. ,
Antigen-loaded MR1 tetramers define T cell receptor heterogeneity in mucosal-associated invariant T cells, J. Exp. Med, vol.210, pp.2305-2320, 2013. ,
Obesity-induced inflammatory changes in adipose tissue, J. Clin. Investig, vol.112, pp.1785-1788, 2003. ,
Adipose tissue-resident immune cells: key players in immunometabolism, Trends Endocrinol. Metab.: TEM, vol.23, pp.407-415, 2012. ,
A novel transcription factor, T-bet, directs Th1 lineage commitment, Cell, vol.100, pp.655-669, 2000. ,
A molecular basis underpinning the T cell receptor heterogeneity of mucosal-associated invariant T cells, J. Exp. Med, vol.211, pp.1585-1600, 2014. ,
Drugs and drug-like molecules can modulate the function of mucosal-associated invariant T cells, Nat. Immunol, vol.18, pp.402-411, 2017. ,
MR1 antigen presentation to mucosal-associated invariant T cells was highly conserved in evolution, Proc. Natl Acad. Sci. USA, vol.106, pp.8290-8295, 2009. ,
A three-stage intrathymic development pathway for the mucosal-associated invariant T cell lineage, Nat. Immunol, vol.17, pp.1300-1311, 2016. ,
Molecular mechanisms of lineage decisions in metabolitespecific T cells, Nat. Immunol, vol.20, pp.1244-1255, 2019. ,
Microbial metabolites control the thymic development of mucosal-associated invariant T cells, Science, vol.366, pp.494-499, 2019. ,
URL : https://hal.archives-ouvertes.fr/hal-02349402
Adipokines in inflammation and metabolic disease, Nat. Rev. Immunol, vol.11, pp.85-97, 2011. ,
Peroxisome proliferator-activated receptor (PPAR) gamma: adipose-predominant expression and induction early in adipocyte differentiation, Endocrinology, vol.135, pp.798-800, 1994. ,
Regulation of PPARgamma activity during adipogenesis, Int. J. Obes, vol.29, issue.1, pp.13-16, 2005. ,
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells, Nature, vol.441, pp.235-238, 2006. ,
The immune cells in adipose tissue, Diabetes, Obes. Metab, vol.15, issue.3, pp.34-38, 2013. ,
The frequencies of immunosuppressive cells in adipose tissue differ in human, non-human primate, and mouse models, Front. Immunol, vol.10, p.117, 2019. ,
URL : https://hal.archives-ouvertes.fr/inserm-02143406
Mucosal-associated invariant T (MAIT) cells are depleted and prone to apoptosis in cardiometabolic disorders, FASEB J, vol.32, pp.5078-5089, 2018. ,
URL : https://hal.archives-ouvertes.fr/inserm-02380779
Cytotoxic and regulatory roles of mucosal-associated invariant T cells in type 1 diabetes, Nat. Immunol, vol.18, pp.1321-1331, 2017. ,
URL : https://hal.archives-ouvertes.fr/inserm-02339318
Mucosal-associated invariant T cells in autoimmune and immune-mediated diseases, Immunol. Cell Biol, vol.96, pp.618-629, 2018. ,
URL : https://hal.archives-ouvertes.fr/inserm-02339443
Mucosal-associated invariant T cells are a profibrogenic immune cell population in the liver, Nat. Commun, vol.9, p.2146, 2018. ,
URL : https://hal.archives-ouvertes.fr/inserm-02339519
Diet-induced alterations of host cholesterol metabolism are likely to affect the gut microbiota composition in hamsters, Appl. Environ. Microbiol, vol.79, pp.516-524, 2013. ,
Metabolic adaptation to a high-fat diet is associated with a change in the gut microbiota, Gut, vol.61, pp.543-553, 2012. ,
URL : https://hal.archives-ouvertes.fr/inserm-00726182
Gut microbiome composition is linked to whole graininduced immunological improvements, ISME J, vol.7, pp.269-280, 2013. ,
Immunomodulatory mechanisms of lactobacilli, Microb. Cell Factories, vol.10, issue.1, p.17, 2011. ,
Changes in gut microbiota control metabolic endotoxemiainduced inflammation in high-fat diet-induced obesity and diabetes in mice, Diabetes, vol.57, pp.1470-1481, 2008. ,
URL : https://hal.archives-ouvertes.fr/inserm-00410066
Microbiota and metabolites in metabolic diseases, Nat. Rev. Endocrinol, vol.15, pp.69-70, 2019. ,
In vitro and in vivo analysis of the gram-negative bacteriaderived riboflavin precursor derivatives activating mouse MAIT cells, J. Immunol, vol.194, pp.4641-4649, 2015. ,
URL : https://hal.archives-ouvertes.fr/hal-01433111
Gut metagenome in European women with normal, impaired and diabetic glucose control, Nature, vol.498, pp.99-103, 2013. ,
Activation and in vivo evolution of the MAIT cell transcriptome in mice and humans reveals tissue repair functionality, Cell Rep, vol.28, pp.3249-3262, 2019. ,
TCR and inflammatory signals tune human MAIT cells to exert specific tissue repair and effector functions, Cell Rep, vol.28, p.3075, 2019. ,
Stepwise Development of MAIT Cells in Mouse and Human, PLoS Biol, vol.7, p.1000054, 2009. ,
URL : https://hal.archives-ouvertes.fr/inserm-00707793
In vivo equilibrium of proinflammatory IL-17 + and regulatory IL-10 + Foxp3 + ROR?t + T cells, J. Exp. Med, vol.205, pp.1381-1393, 2008. ,
Structural insight into MR1-mediated recognition of the mucosal associated invariant T cell receptor, J. Exp. Med, vol.209, pp.761-774, 2012. ,
Production of monoclonal antibodies to group A erythrocytes, HLA and other human cell surface antigens-new tools for genetic analysis, Cell, vol.14, pp.9-20, 1978. ,
Sex differences in the gut microbiome drive hormonedependent regulation of autoimmunity, Science, vol.339, pp.1084-1088, 2013. ,
FLASH: fast length adjustment of short reads to improve genome assemblies, Bioinformatics, vol.27, pp.2957-2963, 2011. ,
Introducing mothur: Open-Source, Platform-Independent, Community-Supported Software for Describing and Comparing Microbial Communities, Appl. Environ. Microbiol, vol.75, pp.7537-7541, 2009. ,
UCHIME improves sensitivity and speed of chimera detection, Bioinformatics, vol.27, pp.2194-2200, 2011. ,
Greengenes, a Chimera-Checked 16S rRNA Gene Database and Workbench Compatible with ARB, Appl. Environ. Microbiol, vol.72, pp.5069-5072, 2006. ,
Naive Bayesian Classifier for Rapid Assignment of rRNA Sequences into the New Bacterial Taxonomy, Appl. Environ. Microbiol, vol.73, pp.5261-5267, 2007. ,
More powerful procedures for multiple significance testing, Stat. Med, vol.9, pp.811-818, 1990. ,