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G. , Representative western blot and quantification of MHC-I, SOD2, and FAK proteins in muscles from WT controls and Prnp -/-mice

H. , Proposed schematic model explaining the relationship between CPT2 deficiency, ROS imbalance, PrP C cleavage, altered FA dynamics and impaired myotubes differentiation

, Results are means of at least three independent experiments carried out on 3 controls. (D) Images are representative of two independent experiments on 2 controls. (E) Four fields of each condition were counted at x20 magnification. (F-G) Results are means of at least three independent experiments performed on 4 WT and 4 Prnp -/-mice

C. and (. , statistical significance was assessed by paired two-tailed Student's t test. For (G), statistical significance was assessed by unpaired two-tailed Student's t test. The P values are