Lung Cancers: Molecular Characterization, Clonal Heterogeneity and Evolution, and Cancer Stem Cells, Cancers (Basel, vol.10, p.248, 2018. ,
How asbestos and other fibers cause mesothelioma, Transl. Lung Cancer Res, vol.2020, pp.39-46 ,
Two cases of squamous carcinoma of the lung occurring in asbestosis, Tubercle, vol.17, pp.5-10, 1935. ,
Lung Tumor Cell-Derived Exosomes Promote M2 Macrophage Polarization, Cells, vol.2020, 1303. ,
Role of exosomal microRNAs in lung cancer biology and clinical applications, Cell Prolif, 2020. ,
MicroRNAs in Tumor Exosomes Drive Immune Escape in Melanoma, Cancer Immunol. Res, 2019. ,
URL : https://hal.archives-ouvertes.fr/inserm-02426329
Most mammalian mRNAs are conserved targets of microRNAs, Genome Res, vol.19, pp.92-105, 2009. ,
Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles, Annu. Rev. Cell Dev. Biol, vol.30, pp.255-289, 2014. ,
URL : https://hal.archives-ouvertes.fr/inserm-02452769
The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes, J. Biol. Chem, vol.288, pp.11649-11661, 2013. ,
Plasma membrane lipid domains as platforms for vesicle biogenesis and shedding?, vol.8, p.94, 2018. ,
Ceramide triggers budding of exosome vesicles into multivesicular endosomes, Science, vol.319, pp.1244-1247, 2008. ,
To be or not to be secreted as exosomes, a balance finely tuned by the mechanisms of biogenesis, Essays Biochem, vol.62, pp.177-191, 2018. ,
Exosomes: Mechanisms of Uptake, J. Circ. Biomark, vol.4, issue.7, 2015. ,
Functional delivery of viral miRNAs via exosomes, Proc. Natl. Acad. Sci, vol.107, pp.6328-6333, 2010. ,
ExoCarta: A Web-Based Compendium of Exosomal Cargo, J. Mol. Biol, vol.428, pp.688-692, 2016. ,
, A compendium for extracellular vesicles with continuous community annotation, vol.10, 2012.
A community web resource for prokaryotic and eukaryotic extracellular vesicles research, Semin. Cell Dev. Biol, vol.40, pp.4-7, 2015. ,
Silvente-Poirot, S. Exosomes as new vesicular lipid transporters involved in cell-cell communication and various pathophysiologies, Biochim. Biophys. Acta, vol.1841, pp.108-120, 2014. ,
PLD2 is enriched on exosomes and its activity is correlated to the release of exosomes, FEBS Lett, vol.572, pp.11-14, 2004. ,
Minimal information for studies of extracellular vesicles 2018 (MISEV2018): A position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines, J. Extracell, vol.7, 2018. ,
Neutral sphingomyelinase 2 (nSMase2)-dependent exosomal transfer of angiogenic microRNAs regulate cancer cell metastasis, J. Biol. Chem, vol.288, pp.10849-10859, 2013. ,
Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs, Nat. Commun, 2013. ,
The RNA-Binding Protein SYNCRIP Is a Component of the Hepatocyte Exosomal Machinery Controlling MicroRNA Sorting, Cell Rep, vol.17, pp.799-808, 2016. ,
Y-box protein 1 is required to sort microRNAs into exosomes in cells and in a cell-free reaction, vol.5, 2016. ,
Nontemplated nucleotide additions distinguish the small RNA composition in cells from exosomes, Cell Rep, vol.8, pp.1649-1658, 2014. ,
Selective extracellular vesicle-mediated export of an overlapping set of microRNAs from multiple cell types, BMC Genom, vol.13, 2012. ,
Tumour-associated macrophages are a distinct M2 polarised population promoting tumour progression: Potential targets of anti-cancer therapy, Eur. J. Cancer, vol.42, pp.717-727, 2006. ,
Macrophage targeting: Opening new possibilities for cancer immunotherapy, Immunology, vol.155, pp.285-293, 2018. ,
Macrophage and Tumor Cell Cross-Talk Is Fundamental for Lung Tumor Progression: We Need to Talk, Front. Oncol, vol.10, 2020. ,
Tumor-derived exosomes in the regulation of macrophage polarization, Inflamm. Res, vol.69, pp.435-451, 2020. ,
Hypoxic Lung-Cancer-Derived Extracellular Vesicle MicroRNA-103a Increases the Oncogenic Effects of Macrophages by Targeting PTEN, Mol. Ther, vol.26, pp.568-581, 2018. ,
Epidermal growth factor receptor-containing exosomes induce tumor-specific regulatory T cells. Cancer Investig, vol.31, pp.330-335, 2013. ,
Tumor-secreted miR-214 induces regulatory T cells: A major link between immune evasion and tumor growth, Cell Res, vol.24, pp.1164-1180, 2014. ,
Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells, J. Clin. Investig, vol.120, pp.457-471, 2010. ,
URL : https://hal.archives-ouvertes.fr/inserm-00451697
Exosomal PD-L1 promotes tumor growth through immune escape in non-small cell lung cancer, Exp. Mol. Med, vol.51, pp.1-13, 2019. ,
Hypoxic tumor-derived microvesicles negatively regulate NK cell function by a mechanism involving TGF-? and miR23a transfer ,
Exosomes and the MICA-NKG2D system in cancer, Blood Cells Mol. Dis, vol.34, pp.206-213, 2005. ,
Cancer exosomes express CD39 and CD73, which suppress T cells through adenosine production, J. Immunol, vol.187, pp.676-683, 2011. ,
Lung cancer exosomes as drivers of epithelial mesenchymal transition, Oncotarget, vol.7, pp.54852-54866, 2016. ,
Exosomes form EGFR-mutated adenocarcinoma induce tumour invasion, Eur. Respir. J, vol.54, 2019. ,
Exosomal Leucine-Rich-Alpha2-Glycoprotein 1 Derived from Non-Small-Cell Lung Cancer Cells Promotes Angiogenesis via TGF-? Signal Pathway, Mol. Ther. Oncolytics, vol.14, pp.313-322, 2019. ,
Exosomal Proteins as Diagnostic Biomarkers in Lung Cancer, J. Thorac. Oncol, vol.11, pp.1701-1710, 2016. ,
Proteomic identification of exosomal LRG1: A potential urinary biomarker for detecting NSCLC, Electrophoresis, vol.32, 1976. ,
Human tumor-derived exosomes selectively impair lymphocyte responses to interleukin-2, Cancer Res, vol.67, pp.7458-7466, 2007. ,
Secreted primary human malignant mesothelioma exosome signature reflects oncogenic cargo, Sci. Rep, vol.6, p.32643, 2016. ,
Hypoxic lung cancer-secreted exosomal miR-23a increased angiogenesis and vascular permeability by targeting prolyl hydroxylase and tight junction protein ZO-1, vol.36, pp.4929-4942, 2017. ,
Exosome cargo reflects TGF-?1-mediated epithelial-to-mesenchymal transition (EMT) status in A549 human lung adenocarcinoma cells, Biochem. Biophys. Res. Commun, vol.478, pp.643-648, 2016. ,
STAT3-regulated exosomal miR-21 promotes angiogenesis and is involved in neoplastic processes of transformed human bronchial epithelial cells, Cancer Lett, vol.370, pp.125-135, 2016. ,
Tissue inhibitor of metalloproteinases-1 induces a pro-tumourigenic increase of miR-210 in lung adenocarcinoma cells and their exosomes, Oncogene, vol.34, pp.3640-3650, 2015. ,
Circulating exosomal microRNAs as prognostic biomarkers for non-small-cell lung cancer, Oncotarget, vol.8, pp.13048-13058, 2017. ,
Exosomal miR-106b serves as a novel marker for lung cancer and promotes cancer metastasis via targeting PTEN, Life Sci, vol.244, 2020. ,
Hypoxic BMSC-derived exosomal miRNAs promote metastasis of lung cancer cells via STAT3-induced EMT, Mol. Cancer, vol.18, pp.1-15, 2019. ,
MicroRNAs derived from circulating exosomes as noninvasive biomarkers for screening and diagnosing lung cancer, J. Thorac. Oncol, vol.8, pp.1156-1162, 2013. ,
Differential miRNA expression in pleural effusions derived from extracellular vesicles of patients with lung cancer, pulmonary tuberculosis, or pneumonia, Tumour Biol, 2016. ,
Cisplatin-Resistant Lung Cancer Cell & Ndash; Derived Exosomes Increase Cisplatin Resistance of Recipient Cells in Exosomal Mir-100 & Ndash; 5p-Dependent Manner, 2020. ,
Exosomal Transfer of Cisplatin-Induced MiR-425-3p Confers Cisplatin Resistance in NSCLC Through Activating Autophagy, 2020. ,
Exosome-mediated gefitinib resistance in lung cancer HCC827 cells via delivery of miR-21, Oncol. Lett, vol.15, pp.9811-9817, 2018. ,
Exosomal transfer of miR-214 mediates gefitinib resistance in non-small cell lung cancer, Biochem. Biophys. Res. Commun, vol.507, pp.457-464, 2018. ,
Exosomal miR-499a-5p promotes cell proliferation, migration and EMT via mTOR signaling pathway in lung adenocarcinoma, Exp. Cell Res, vol.379, pp.203-213, 2019. ,
Extracellular vesicle-delivered miR-505-5p, as a diagnostic biomarker of early lung adenocarcinoma, inhibits cell apoptosis by targeting TP53AIP1, Int. J. Oncol, vol.54, pp.1821-1832, 2019. ,
Exosomal miR-660-5p promotes tumor growth and metastasis in non-small cell lung cancer, J. BUON, vol.24, pp.599-607, 2019. ,
Exosomal microRNA: A diagnostic marker for lung cancer, Clin. Lung Cancer, vol.10, pp.42-46, 2009. ,
Different exosome cargo from plasma/bronchoalveolar lavage in non-small-cell lung cancer, Genes Chromosomes Cancer, vol.53, pp.713-724, 2014. ,
EV-associated miRNAs from pleural lavage as potential diagnostic biomarkers in lung cancer, Sci. Rep, vol.9, 2019. ,
Detection of circulating exosomal miR-17-5p serves as a novel non-invasive diagnostic marker for non-small cell lung cancer patients, Pathol. Res. Pract, vol.215, 2019. ,
Evaluation of Tumor-Derived Exosomal miRNA as Potential Diagnostic Biomarkers for Early-Stage Non-Small Cell Lung Cancer Using Next-Generation Sequencing, Clin. Cancer Res, vol.23, pp.5311-5319, 2017. ,
Vesicle-related microRNAs in plasma of nonsmall cell lung cancer patients and correlation with survival, Eur. Respir. J, vol.37, pp.617-623, 2011. ,
Serum exosomal miR-378 upregulation is associated with poor prognosis in non-small-cell lung cancer patients, J. Clin. Lab. Anal, vol.2020, 23237. ,
Exosomal microRNA in plasma as a non-invasive biomarker for the recurrence of non-small cell lung cancer, Oncol. Lett, vol.13, pp.1256-1263, 2017. ,
Circulating miRNAs and extracellular vesicle containing miRNAs as response biomarkers of anti PD-1/PD-L1 therapy in non-small-cell lung cancer, J. Thorac. Oncol, 2020. ,
MiR-146a-5p level in serum exosomes predicts therapeutic effect of cisplatin in non-small cell lung cancer, Eur. Rev. Med. Pharmacol. Sci, vol.21, pp.2650-2658, 2017. ,
Follow up analysis by exosomal miRNAs in EGFR mutated non-small cell lung cancer (NSCLC) patients during osimertinib (AZD9291) treatment: A potential prognostic biomarker tool, vol.34, 2016. ,
Exosomal miR-16-5p as a target for malignant mesothelioma, Sci. Rep, vol.9, 2019. ,
Plasmatic extracellular vesicle microRNAs in malignant pleural mesothelioma and asbestos-exposed subjects suggest a 2-miRNA signature as potential biomarker of disease, PLoS ONE, vol.12, 2017. ,
Single-Cell RNA Sequencing Maps Endothelial Metabolic Plasticity in Pathological Angiogenesis, Cell Metab, vol.31, pp.862-877, 2020. ,
MiR-23a regulates TGF-?-induced epithelial-mesenchymal transition by targeting E-cadherin in lung cancer cells, Int. J. Oncol, vol.41, pp.869-875, 2012. ,
Circulating exosomal microRNA-96 promotes cell proliferation, migration and drug resistance by targeting LMO7, J. Cell. Mol. Med, vol.21, pp.1228-1236, 2017. ,
The distribution of secondary growths in cancer of the breast. 1889, Cancer Metastasis Rev, vol.8, pp.98-101, 1989. ,
Progression and metastasis of lung cancer, Cancer Metastasis Rev, vol.35, pp.75-91, 2016. ,
Postmortem findings of malignant pleural mesothelioma: A two-center study of 318 patients, Chest, vol.142, pp.1267-1273, 2012. ,
Extracellular vesicle tetraspanin-8 level predicts distant metastasis in non-small cell lung cancer after concurrent chemoradiation ,
Tumour exosome integrins determine organotropic metastasis, Nature, vol.527, pp.329-335, 2015. ,
Platelet integrin ?6?1 controls lung metastasis through direct binding to cancer cell-derived ADAM9, JCI Insight, vol.1, 2016. ,
Levels of Extracellular Vesicles in Pulmonary and Peripheral Blood Correlate with Stages of Lung Cancer Patients, World J. Surg, 2020. ,
Plasma exosome levels in non-small-cell lung cancer: Correlation with clinicopathological features and prognostic implications, Cancer Biomark, vol.22, pp.267-274, 2018. ,
Counting on extracellular vesicles for glioblastoma patients, Oncogene, vol.2020, pp.1-10 ,
URL : https://hal.archives-ouvertes.fr/inserm-02915935
Triple SILAC quantitative proteomic analysis reveals differential abundance of cell signaling proteins between normal and lung cancer-derived exosomes, J. Proteom, vol.133, pp.161-169, 2016. ,
Exosomal proteins as prognostic biomarkers in non-small cell lung cancer, Mol. Oncol, vol.10, pp.1595-1602, 2016. ,
Unique microRNA molecular profiles in lung cancer diagnosis and prognosis, Cancer Cell, vol.9, pp.189-198, 2006. ,
Extracellular Vesicle lincRNA-p21 Expression in Tumor-Draining Pulmonary Vein Defines Prognosis in NSCLC and Modulates Endothelial Cell Behavior, Cancers ,
Tumor-released lncRNA H19 promotes gefitinib resistance via packaging into exosomes in non-small cell lung cancer, Oncol. Rep, vol.40, pp.3438-3446, 2018. ,
Role of exosomes and exosomal microRNAs in cancer, Future Sci, vol.2020 ,
Exosomal miRNAs as cancer biomarkers and therapeutic targets, J. Extracell. Vesicles, vol.5, p.31292, 2016. ,
MiR-1289 and "Zipcode"-Like Sequence Enrich mRNAs in Microvesicles, Mol. Ther. Nucleic Acids, vol.1, 2012. ,
Exosome removal as a therapeutic adjuvant in cancer, J. Transl. Med, vol.10, 2012. ,
MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response, Proc. Natl. Acad. Sci, vol.109, pp.2110-2116, 2012. ,
Accelerated growth of B16BL6 tumor in mice through efficient uptake of their own exosomes by B16BL6 cells, Cancer Sci, vol.108, pp.1803-1810, 2017. ,
Extracellular vesicles: Potential roles in regenerative medicine, Front. Immunol, vol.5, 2014. ,
Effects of gefitinib treatment on cellular uptake of extracellular vesicles in EGFR-mutant non-small cell lung cancer cells, Int. J. Pharm, vol.572, 2019. ,
Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells, Nanomedicine, vol.12, pp.655-664, 2016. ,
Manufacturing Exosomes: A Promising Therapeutic Platform, Trends Mol. Med, vol.24, pp.242-256, 2018. ,
Production of plasma membrane vesicles with chloride salts and their utility as a cell membrane mimetic for biophysical characterization of membrane protein interactions, Anal. Chem, vol.84, pp.8650-8655, 2012. ,
Investigating cellular signaling reactions in single attoliter vesicles, J. Am. Chem. Soc, vol.127, pp.2908-2912, 2005. ,
Generation and testing of clinical-grade exosomes for pancreatic cancer, JCI Insight, vol.3, 2018. ,
Lipid Nano-and Microparticles: An Overview of Patent-Related Research, 2020. ,
Exosome-mimetic nanoplatforms for targeted cancer drug delivery, J. Nanobiotechnol, vol.17, 2019. ,
A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy, Biomaterials, vol.35, pp.2383-2390, 2014. ,
Integrin expression profiling identifies integrin alpha5 and beta1 as prognostic factors in early stage non-small cell lung cancer, Mol. Cancer, vol.9, p.152, 2010. ,
Engineered extracellular vesicles with synthetic lipids via membrane fusion to establish efficient gene delivery, Int. J. Pharm, vol.573, p.118802, 2020. ,
Viral cancer therapies: Are they ready for combination with other immunotherapies? Future Oncol, vol.13, pp.1569-1571, 2017. ,
Delivery of oncolytic adenovirus into the nucleus of tumorigenic cells by tumor microparticles for virotherapy, Biomaterials, vol.89, pp.56-66, 2016. ,
Antitumor effect of oncolytic virus and paclitaxel encapsulated in extracellular vesicles for lung cancer treatment, J. Control, vol.283, pp.223-234, 2018. ,
Extracellular vesicles enhance the targeted delivery of immunogenic oncolytic adenovirus and paclitaxel in immunocompetent mice, J. Control. Release, vol.294, pp.165-175, 2019. ,
A phase I study of dexosome immunotherapy in patients with advanced non-small cell lung cancer, J. Transl. Med, vol.3, issue.9, 2005. ,
Dendritic cell-derived exosomes as maintenance immunotherapy after first line chemotherapy in NSCLC ,
URL : https://hal.archives-ouvertes.fr/hal-01440237
Autologous tumor cell-derived microparticle-based targeted chemotherapy in lung cancer patients with malignant pleural effusion, Sci. Transl. Med, vol.11, 2019. ,
, This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license, © 2020 by the authors. Licensee MDPI