Fueling immunity: insights into metabolism and lymphocyte function, Science, vol.342, p.1242454, 2013. ,
mTOR signaling at a glance, J. Cell Sci, vol.122, pp.3589-3594, 2009. ,
Prolonged TCR/ CD28 engagement drives IL-2-independent T cell clonal expansion through signaling mediated by the mammalian target of rapamycin, J. Immunol, vol.176, pp.2730-2738, 2006. ,
A role for mammalian target of rapamycin in regulating T cell activation versus anergy, J. Immunol, vol.178, pp.2163-2170, 2007. ,
Anergic T cells are metabolically anergic, J. Immunol, vol.183, pp.6095-6101, 2009. ,
The AKT-mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells, J. Exp. Med, vol.205, pp.565-574, 2008. ,
T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR, Proc. Natl. Acad. Sci. USA, vol.105, pp.7797-7802, 2008. ,
The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment, Immunity, vol.30, pp.832-844, 2009. ,
The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2, Nat. Immunol, vol.12, pp.295-303, 2011. ,
mTOR and metabolic regulation of conventional and regulatory T cells, J. Leukoc. Biol, vol.97, pp.837-847, 2015. ,
Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets, J. Immunol, vol.186, pp.3299-3303, 2011. ,
Foxp3-mediated inhibition of Akt inhibits Glut1 (glucose transporter 1) expression in human T regulatory cells, J. Leukoc. Biol, vol.97, pp.279-283, 2015. ,
Foxp3 and toll-like receptor signaling balance T reg cell anabolic metabolism for suppression, Nat. Immunol, vol.17, pp.1459-1466, 2016. ,
Foxp3 reprograms T cell metabolism to function in low-glucose, high-lactate environments, Cell Metab, vol.25, pp.1282-1293, 2017. ,
Glycolysis controls the induction of human regulatory T cells by modulating the expression of FOXP3 exon 2 splicing variants, Nat. Immunol, vol.16, pp.1174-1184, 2015. ,
The proteomic landscape of human ex vivo regulatory and conventional T cells reveals specific metabolic requirements, Immunity, vol.44, pp.406-421, 2016. ,
2013. mTORC1 couples immune signals and metabolic programming to establish T(reg)-cell function, Nature, vol.499, pp.485-490 ,
mTOR coordinates transcriptional programs and mitochondrial metabolism of activated T reg subsets to protect tissue homeostasis, Nat. Commun, vol.9, p.2095, 2018. ,
Cutting edge: TGF-b and phosphatidylinositol 3-kinase signals modulate distinct metabolism of regulatory T cell subsets, J. Immunol, vol.201, pp.2215-2219, 2018. ,
mTOR complex 1 signaling regulates the generation and function of central and effector Foxp3 + regulatory T cells, J. Immunol, vol.201, pp.481-492, 2018. ,
Foxo1 is a T cell-intrinsic inhibitor of the RORgt-Th17 program, J. Immunol, vol.195, pp.1791-1803, 2015. ,
Analysis of cell metabolism using LC-MS and isotope tracers, Methods Enzymol, vol.561, pp.171-196, 2015. ,
Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy, J. Cell Biol, vol.187, pp.859-874, 2009. ,
URL : https://hal.archives-ouvertes.fr/hal-02126916
Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces, Immunity, vol.28, pp.546-558, 2008. ,
Guidance factors orchestrating regulatory T cell positioning in tissues during development, homeostasis, and response, Immunol. Rev, vol.289, pp.129-141, 2019. ,
Metabolism, migration and memory in cytotoxic T cells, Nat. Rev. Immunol, vol.11, pp.109-117, 2011. ,
Peripheral tolerance can be modified by altering KLF2-regulated Treg migration, Proc. Natl. Acad. Sci. USA, vol.113, pp.4662-4670, 2016. ,
Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival, Nat. Med, vol.10, pp.942-949, 2004. ,
Altering the distribution of Foxp3(+) regulatory T cells results in tissue-specific inflammatory disease, J. Exp. Med, vol.204, pp.1335-1347, 2007. ,
Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo, Nat. Immunol, vol.10, pp.1000-1007, 2009. ,
Natural Treg cells spontaneously differentiate into pathogenic helper cells in lymphopenic conditions, Eur. J. Immunol, vol.39, pp.948-955, 2009. ,
Cutting edge: regulatory T cells induce CD4+CD25-Foxp3-T cells or are self-induced to become Th17 cells in the absence of exogenous TGF-beta, J. Immunol, vol.178, pp.6725-6729, 2007. ,
Molecular antagonism and plasticity of regulatory and inflammatory T cell programs, Immunity, vol.29, pp.44-56, 2008. ,
Plasticity of CD4(+) FoxP3(+) T cells, Curr. Opin. Immunol, vol.21, pp.281-285, 2009. ,
Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer, Nat. Immunol, vol.9, pp.194-202, 2008. ,
An essential role of the Forkhead-box transcription factor Foxo1 in control of T cell homeostasis and tolerance, Immunity, vol.30, pp.358-371, 2009. ,
Graded Foxo1 activity in Treg cells differentiates tumour immunity from spontaneous autoimmunity, Nature, vol.529, pp.532-536, 2016. ,
Regulatory T cell migration is dependent on glucokinase-mediated glycolysis, Immunity, vol.48, pp.875-889, 2017. ,
Glutamine-dependent a-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation, Sci. Signal, vol.8, p.97, 2015. ,
Metabolic control of T H 17 and induced T reg cell balance by an epigenetic mechanism, Nature, vol.548, pp.228-233, 2017. ,
Functional reprogramming of regulatory T cells in the absence of Foxp3, Nat. Immunol, vol.20, pp.1208-1219, 2019. ,