J. L. Leahy, Pathogenesis of type 2 diabetes mellitus, Arch. Med. Res, vol.36, pp.197-209, 2005.

B. Ahrén, Islet G protein-coupled receptors as potential targets for treatment of type 2 diabetes, Nat. Rev. Drug Discov, vol.8, pp.369-385, 2009.

D. Wootten, A. Christopoulos, M. Marti-solano, M. M. Babu, and P. M. Sexton, Mechanisms of signalling and biased agonism in G protein-coupled receptors, Nat. Rev. Mol. Cell Biol, vol.19, pp.638-653, 2018.

N. J. Pavlos and P. A. Friedman, GPCR signaling and trafficking: the long and short of it, Trends Endocrinol. Metab, vol.28, pp.213-226, 2017.

N. G. Bowery, International Union of Pharmacology. XXXIII. Mammalian gamma-aminobutyric acid(B) receptors: structure and function, Pharmacol. Rev, vol.54, pp.247-264, 2002.

R. W. Olsen and W. Sieghart, International union of lassification on the basis of subunit composition, pharmacology, and function, Pharmacol. Rev, vol.60, pp.243-260, 2008.

S. D. Chessler and A. Lernmark, Alternative splicing of GAD67 results in the synthesis of a third form of glutamic-acid decarboxylase in human islets and other non-neural tissues, J. Biol. Chem, vol.275, pp.5188-5192, 2000.

M. Braun, Gamma-aminobutyric acid (GABA) is an autocrine excitatory transmitter in human pancreatic beta-cells, Diabetes, vol.59, pp.1694-1701, 2010.

S. V. Korol, Functional characterization of native, high-affinity GABAA receptors in human pancreatic ? cells. EBioMedicine, vol.30, pp.273-282, 2018.

S. Amisten, A. Salehi, P. Rorsman, P. M. Jones, and S. J. Persaud, An atlas and functional analysis of G-protein coupled receptors in human islets of Langerhans, Pharmacol. Ther, vol.139, pp.359-391, 2013.

M. Braun, GABAB receptor activation inhibits exocytosis in rat pancreatic beta-cells by G-protein-dependent activation of calcineurin, J. Physiol. (Lond.), vol.559, pp.397-409, 2004.

Q. Wang, L. Ren, Y. Wan, and G. J. Prud'homme, GABAergic regulation of pancreatic islet cells: physiology and antidiabetic effects, J. Cell. Physiol, 2019.

J. Tian, ?-Aminobutyric acid regulates both the survival and replication of human ?-cells, Diabetes, vol.62, pp.3760-3765, 2013.

D. R. Hill and N. G. Bowery, 3H-baclofen and 3H-GABA bind to bicuculline-insensitive GABA B sites in rat brain, Nature, vol.290, pp.149-152, 1981.

R. Scharfmann, Development of a conditionally immortalized human pancreatic ? cell line, J. Clin. Invest, vol.124, pp.2087-2098, 2014.
URL : https://hal.archives-ouvertes.fr/hal-01329344

P. Ravassard, A genetically engineered human pancreatic ? cell line exhibiting glucose-inducible insulin secretion, J. Clin. Invest, vol.121, pp.3589-3597, 2011.

D. R. Hill, GABAB receptor modulation of adenylate cyclase activity in rat brain slices, Br. J. Pharmacol, vol.84, pp.249-257, 1985.

K. Kaupmann, Human gamma-aminobutyric acid type B receptors are differentially expressed and regulate inwardly rectifying K+ channels, Proc. Natl. Acad. Sci. USA, vol.95, pp.14991-14996, 1998.

Y. Odagaki and T. Koyama, Identification of galpha subtype(s) involved in gamma-aminobutyric acid(B) receptor-mediated highaffinity guanosine triphosphatase activity in rat cerebral cortical membranes, Neurosci. Lett, vol.297, pp.137-141, 2001.

P. Richards, MondoA is an essential glucose-responsive transcription factor in human pancreatic ?-cells, Diabetes, vol.67, pp.461-472, 2018.
URL : https://hal.archives-ouvertes.fr/hal-02400698

E. G. Siegel and W. Creutzfeldt, Stimulation of insulin release in isolated rat islets by GIP in physiological concentrations and its relation to islet cyclic AMP content, Diabetologia, vol.28, pp.857-861, 1985.

B. Furman, W. K. Ong, and N. J. Pyne, Cyclic AMP signaling in pancreatic islets, Adv. Exp. Med. Biol, vol.654, pp.281-304, 2010.

H. E. Arda, Age-dependent pancreatic gene regulation reveals mechanisms governing human ? cell function, Cell Metab, vol.23, pp.909-920, 2016.

S. Culina, Islet-reactive CD8+ T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors, Sci Immunol, vol.3, 2018.
URL : https://hal.archives-ouvertes.fr/inserm-01918833

K. A. Jones, GABA(B) receptors function as a heteromeric assembly of the subunits GABA(B)R1 and GABA(B)R2, Nature, vol.396, pp.674-679, 1998.

K. Kaupmann, GABA(B)-receptor subtypes assemble into functional heteromeric complexes, Nature, vol.396, pp.683-687, 1998.

R. Kuner, Role of heteromer formation in GABAB receptor function, Science, vol.283, pp.74-77, 1999.

J. H. White, Heterodimerization is required for the formation of a functional GABA(B) receptor, Nature, vol.396, pp.679-682, 1998.

J. Ong and D. I. Kerr, GABA-receptors in peripheral tissues, Life Sci, vol.46, pp.1489-1501, 1990.

N. G. Bowery, A. L. Hudson, and G. W. Price, GABAA and GABAB receptor site distribution in the rat central nervous system, Neuroscience, vol.20, pp.365-383, 1987.

N. G. Bowery, GABAB receptor pharmacology, Annu. Rev. Pharmacol. Toxicol, vol.33, pp.109-147, 1993.

J. B. Regard, I. T. Sato, and S. R. Coughlin, Anatomical profiling of G protein-coupled receptor expression, Cell, vol.135, pp.561-571, 2008.

M. E. Arntfield and D. Van-der-kooy, ?-Cell evolution: How the pancreas borrowed from the brain: the shared toolbox of genes expressed by neural and pancreatic endocrine cells may reflect their evolutionary relationship, BioEssays, vol.33, pp.582-587, 2011.

S. Doly, GABAB receptor cell-surface export is controlled by an endoplasmic reticulum gatekeeper, Mol. Psychiatry, vol.21, pp.480-490, 2016.
URL : https://hal.archives-ouvertes.fr/inserm-01153352

A. Couve, Cyclic AMP-dependent protein kinase phosphorylation facilitates GABA(B) receptor-effector coupling, Nat. Neurosci, vol.5, pp.415-424, 2002.

S. Seino, H. Takahashi, W. Fujimoto, and T. Shibasaki, Roles of cAMP signalling in insulin granule exocytosis, Diabetes Obes Metab, vol.11, pp.180-188, 2009.

B. Svendsen, Insulin Secretion depends on intra-islet glucagon signaling, Cell Rep, vol.25, 2018.

L. Zhu, Intra-islet glucagon signaling is critical for maintaining glucose homeostasis, JCI Insight, vol.5, 2019.

, Scientific RepoRtS |, vol.10, p.13469, 2020.

V. G. Tsonkova, The EndoC-?H1 cell line is a valid model of human beta cells and applicable for screenings to identify novel drug target candidates, Mol. Metab, vol.8, pp.144-157, 2018.

J. Suckale and M. Solimena, The insulin secretory granule as a signaling hub, Trends Endocrinol. Metab, vol.21, pp.599-609, 2010.

P. Rorsman, Activation by adrenaline of a low-conductance G protein-dependent K+ channel in mouse pancreatic B cells, Nature, vol.349, pp.77-79, 1991.

E. Blanchet, Feedback inhibition of CREB signaling promotes beta cell dysfunction in insulin resistance, Cell. Rep, vol.10, pp.1149-1157, 2015.

Y. Hang and R. Stein, MafA and MafB activity in pancreatic ? cells, Trends Endocrinol. Metab, vol.22, pp.364-373, 2011.

D. F. Steiner and D. E. James, Cellular and molecular biology of the beta cell, Diabetologia, vol.35, issue.2, pp.41-48, 1992.

B. Sosa-pineda, K. Chowdhury, M. Torres, G. Oliver, and P. Gruss, The Pax4 gene is essential for differentiation of insulin-producing beta cells in the mammalian pancreas, Nature, vol.386, pp.399-402, 1997.

P. I. Lorenzo, N. Cobo-vuilleumier, and B. R. Gauthier, Therapeutic potential of pancreatic PAX4-regulated pathways in treating diabetes mellitus, Curr. Opin. Pharmacol, vol.43, pp.1-10, 2018.

Z. Chen, cAMP/CREB-regulated LINC00473 marks LKB1-inactivated lung cancer and mediates tumor growth, J. Clin. Invest, vol.126, pp.2267-2279, 2016.

S. Herzberg-schäfer, M. Heni, N. Stefan, H. Häring, and A. Fritsche, Impairment of GLP1-induced insulin secretion: role of genetic background, insulin resistance and hyperglycaemia, Diabetes Obes. Metab, vol.14, issue.3, pp.85-90, 2012.

M. Castaing, Blood glucose normalization upon transplantation of human embryonic pancreas into beta-cell-deficient SCID mice, Diabetologia, vol.44, pp.2066-2076, 2001.

M. Oshima, Virus-like infection induces human ? cell dedifferentiation, JCI Insight, vol.3, 2018.

F. Ihler, Expression of a neuroendocrine gene signature in gastric tumor cells from CEA 424-SV40 large T antigen-transgenic mice depends on SV40 large T antigen, PLoS ONE, vol.7, p.29846, 2012.

B. Duvillié, The mesenchyme controls the timing of pancreatic beta-cell differentiation, Diabetes, vol.55, pp.582-589, 2006.