Pathogenesis of type 2 diabetes mellitus, Arch. Med. Res, vol.36, pp.197-209, 2005. ,
Islet G protein-coupled receptors as potential targets for treatment of type 2 diabetes, Nat. Rev. Drug Discov, vol.8, pp.369-385, 2009. ,
Mechanisms of signalling and biased agonism in G protein-coupled receptors, Nat. Rev. Mol. Cell Biol, vol.19, pp.638-653, 2018. ,
GPCR signaling and trafficking: the long and short of it, Trends Endocrinol. Metab, vol.28, pp.213-226, 2017. ,
International Union of Pharmacology. XXXIII. Mammalian gamma-aminobutyric acid(B) receptors: structure and function, Pharmacol. Rev, vol.54, pp.247-264, 2002. ,
International union of lassification on the basis of subunit composition, pharmacology, and function, Pharmacol. Rev, vol.60, pp.243-260, 2008. ,
Alternative splicing of GAD67 results in the synthesis of a third form of glutamic-acid decarboxylase in human islets and other non-neural tissues, J. Biol. Chem, vol.275, pp.5188-5192, 2000. ,
Gamma-aminobutyric acid (GABA) is an autocrine excitatory transmitter in human pancreatic beta-cells, Diabetes, vol.59, pp.1694-1701, 2010. ,
Functional characterization of native, high-affinity GABAA receptors in human pancreatic ? cells. EBioMedicine, vol.30, pp.273-282, 2018. ,
An atlas and functional analysis of G-protein coupled receptors in human islets of Langerhans, Pharmacol. Ther, vol.139, pp.359-391, 2013. ,
GABAB receptor activation inhibits exocytosis in rat pancreatic beta-cells by G-protein-dependent activation of calcineurin, J. Physiol. (Lond.), vol.559, pp.397-409, 2004. ,
GABAergic regulation of pancreatic islet cells: physiology and antidiabetic effects, J. Cell. Physiol, 2019. ,
?-Aminobutyric acid regulates both the survival and replication of human ?-cells, Diabetes, vol.62, pp.3760-3765, 2013. ,
3H-baclofen and 3H-GABA bind to bicuculline-insensitive GABA B sites in rat brain, Nature, vol.290, pp.149-152, 1981. ,
Development of a conditionally immortalized human pancreatic ? cell line, J. Clin. Invest, vol.124, pp.2087-2098, 2014. ,
URL : https://hal.archives-ouvertes.fr/hal-01329344
A genetically engineered human pancreatic ? cell line exhibiting glucose-inducible insulin secretion, J. Clin. Invest, vol.121, pp.3589-3597, 2011. ,
GABAB receptor modulation of adenylate cyclase activity in rat brain slices, Br. J. Pharmacol, vol.84, pp.249-257, 1985. ,
Human gamma-aminobutyric acid type B receptors are differentially expressed and regulate inwardly rectifying K+ channels, Proc. Natl. Acad. Sci. USA, vol.95, pp.14991-14996, 1998. ,
Identification of galpha subtype(s) involved in gamma-aminobutyric acid(B) receptor-mediated highaffinity guanosine triphosphatase activity in rat cerebral cortical membranes, Neurosci. Lett, vol.297, pp.137-141, 2001. ,
MondoA is an essential glucose-responsive transcription factor in human pancreatic ?-cells, Diabetes, vol.67, pp.461-472, 2018. ,
URL : https://hal.archives-ouvertes.fr/hal-02400698
Stimulation of insulin release in isolated rat islets by GIP in physiological concentrations and its relation to islet cyclic AMP content, Diabetologia, vol.28, pp.857-861, 1985. ,
Cyclic AMP signaling in pancreatic islets, Adv. Exp. Med. Biol, vol.654, pp.281-304, 2010. ,
Age-dependent pancreatic gene regulation reveals mechanisms governing human ? cell function, Cell Metab, vol.23, pp.909-920, 2016. ,
Islet-reactive CD8+ T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors, Sci Immunol, vol.3, 2018. ,
URL : https://hal.archives-ouvertes.fr/inserm-01918833
GABA(B) receptors function as a heteromeric assembly of the subunits GABA(B)R1 and GABA(B)R2, Nature, vol.396, pp.674-679, 1998. ,
GABA(B)-receptor subtypes assemble into functional heteromeric complexes, Nature, vol.396, pp.683-687, 1998. ,
Role of heteromer formation in GABAB receptor function, Science, vol.283, pp.74-77, 1999. ,
Heterodimerization is required for the formation of a functional GABA(B) receptor, Nature, vol.396, pp.679-682, 1998. ,
GABA-receptors in peripheral tissues, Life Sci, vol.46, pp.1489-1501, 1990. ,
GABAA and GABAB receptor site distribution in the rat central nervous system, Neuroscience, vol.20, pp.365-383, 1987. ,
GABAB receptor pharmacology, Annu. Rev. Pharmacol. Toxicol, vol.33, pp.109-147, 1993. ,
Anatomical profiling of G protein-coupled receptor expression, Cell, vol.135, pp.561-571, 2008. ,
?-Cell evolution: How the pancreas borrowed from the brain: the shared toolbox of genes expressed by neural and pancreatic endocrine cells may reflect their evolutionary relationship, BioEssays, vol.33, pp.582-587, 2011. ,
GABAB receptor cell-surface export is controlled by an endoplasmic reticulum gatekeeper, Mol. Psychiatry, vol.21, pp.480-490, 2016. ,
URL : https://hal.archives-ouvertes.fr/inserm-01153352
Cyclic AMP-dependent protein kinase phosphorylation facilitates GABA(B) receptor-effector coupling, Nat. Neurosci, vol.5, pp.415-424, 2002. ,
Roles of cAMP signalling in insulin granule exocytosis, Diabetes Obes Metab, vol.11, pp.180-188, 2009. ,
Insulin Secretion depends on intra-islet glucagon signaling, Cell Rep, vol.25, 2018. ,
Intra-islet glucagon signaling is critical for maintaining glucose homeostasis, JCI Insight, vol.5, 2019. ,
, Scientific RepoRtS |, vol.10, p.13469, 2020.
The EndoC-?H1 cell line is a valid model of human beta cells and applicable for screenings to identify novel drug target candidates, Mol. Metab, vol.8, pp.144-157, 2018. ,
The insulin secretory granule as a signaling hub, Trends Endocrinol. Metab, vol.21, pp.599-609, 2010. ,
Activation by adrenaline of a low-conductance G protein-dependent K+ channel in mouse pancreatic B cells, Nature, vol.349, pp.77-79, 1991. ,
Feedback inhibition of CREB signaling promotes beta cell dysfunction in insulin resistance, Cell. Rep, vol.10, pp.1149-1157, 2015. ,
MafA and MafB activity in pancreatic ? cells, Trends Endocrinol. Metab, vol.22, pp.364-373, 2011. ,
Cellular and molecular biology of the beta cell, Diabetologia, vol.35, issue.2, pp.41-48, 1992. ,
The Pax4 gene is essential for differentiation of insulin-producing beta cells in the mammalian pancreas, Nature, vol.386, pp.399-402, 1997. ,
Therapeutic potential of pancreatic PAX4-regulated pathways in treating diabetes mellitus, Curr. Opin. Pharmacol, vol.43, pp.1-10, 2018. ,
cAMP/CREB-regulated LINC00473 marks LKB1-inactivated lung cancer and mediates tumor growth, J. Clin. Invest, vol.126, pp.2267-2279, 2016. ,
Impairment of GLP1-induced insulin secretion: role of genetic background, insulin resistance and hyperglycaemia, Diabetes Obes. Metab, vol.14, issue.3, pp.85-90, 2012. ,
Blood glucose normalization upon transplantation of human embryonic pancreas into beta-cell-deficient SCID mice, Diabetologia, vol.44, pp.2066-2076, 2001. ,
Virus-like infection induces human ? cell dedifferentiation, JCI Insight, vol.3, 2018. ,
Expression of a neuroendocrine gene signature in gastric tumor cells from CEA 424-SV40 large T antigen-transgenic mice depends on SV40 large T antigen, PLoS ONE, vol.7, p.29846, 2012. ,
The mesenchyme controls the timing of pancreatic beta-cell differentiation, Diabetes, vol.55, pp.582-589, 2006. ,