Genomic analysis of the host response to hepatitis B virus infection, Proc. Natl. Acad. Sci. U.S.A, vol.101, pp.6669-6674, 2004. ,
Temporal analysis of early immune responses in patients with acute hepatitis B virus infection, Gastroenterology, vol.137, pp.1289-1300, 2009. ,
Epidemiology of viral hepatitis and hepatocellular carcinoma, Gastroenterology, vol.142, pp.1264-1273, 2012. ,
, European Association for the Study of the, L. EASL. Clinical Practice guidelines on the management of hepatitis B virus infection, European Association for the Study of the Liver. Electronic address, vol.67, pp.370-398, 2017.
Hepatitis B virus infection, Lancet, vol.384, issue.14, pp.60220-60228, 2014. ,
URL : https://hal.archives-ouvertes.fr/hal-02649042
Hepatitis B cure: From discovery to regulatory approval, Hepatology, vol.66, pp.1296-1313, 2017. ,
Current treatments for chronic hepatitis B virus infections, Curr. Opin. Virol, vol.18, pp.109-116, 2016. ,
URL : https://hal.archives-ouvertes.fr/hal-01796195
IFN-alpha inhibits HBV transcription and replication in cell culture and in humanized mice by targeting the epigenetic regulation of the nuclear cccDNA minichromosome, J. Clin. Investig, vol.122, pp.529-537, 2012. ,
Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA, Science, vol.343, p.62, 2014. ,
Interferon-gamma and tumor necrosis factor-alpha produced by T cells reduce the HBV persistence form, cccDNA without cytolysis A, Gastroenterology, vol.150, pp.194-205, 2016. ,
Comparative analysis of the antiviral effects mediated by type I and III Interferons in Hepatitis B virusinfected Hepatocytes, J. Infect. Dis, vol.220, pp.567-577, 2019. ,
Hepatitis B virus does not interfere with innate immune responses in the human liver, Gastroenterology, vol.154, pp.1778-1790, 2018. ,
Secreted interferon-inducible factors restrict Hepatitis B and C virus entry in vitro, J. Immunol. Res, 2017. ,
PKR-dependent mechanisms of interferon-alpha for inhibiting hepatitis B virus replication, Mol. Cells, vol.32, pp.167-172, 2011. ,
The Interferon-inducible protein tetherin Inhibits Hepatitis B virus virion secretion, J. Virol, vol.89, pp.9200-9212, 2015. ,
Antiviral activity of various interferons and pro-inflammatory cytokines in non-transformed cultured hepatocytes infected with hepatitis B virus, Antivir. Res, vol.130, pp.36-45, 2016. ,
URL : https://hal.archives-ouvertes.fr/hal-01797274
Control of Hepatitis B virus by cytokines, vol.9, 2017. ,
Not interferon, but interleukin-6 controls early gene expression in hepatitis B virus infection, Hepatology, vol.50, pp.1773-1782, 2009. ,
The role of tumour necrosis factor in hepatitis B infection: Jekyll and Hyde, Clin. Transl. Immunol, vol.5, 2016. ,
GS-9620, an oral agonist of Toll-like receptor-7, induces prolonged suppression of hepatitis B virus in chronically infected chimpanzees, Gastroenterology, vol.144, pp.1508-1517, 2013. ,
Combination therapy including CpG oligodeoxynucleotides and entecavir induces early viral response and enhanced inhibition of viral replication in a woodchuck model of chronic hepadnaviral infection, Antivir. Res, vol.125, pp.14-24, 2016. ,
Sustained efficacy and seroconversion with the Toll-like receptor 7 agonist GS-9620 in the Woodchuck model of chronic hepatitis B, J. Hepatol, vol.62, pp.1237-1245, 2015. ,
Direct antiviral properties of TLR ligands against HBV replication in immune-competent hepatocytes, Sci. Rep, vol.8, 2018. ,
URL : https://hal.archives-ouvertes.fr/hal-01953649
Toll-like receptor 7 agonist GS-9620 induces prolonged inhibition of HBV via a type I interferon-dependent mechanism, J. Hepatol, vol.68, pp.922-931, 2018. ,
Characterization of pattern recognition receptor expression and functionality in liver primary cells and derived cell lines, J. Innate Immun, vol.10, pp.1-10, 2018. ,
The MEK1/2-ERK pathway inhibits type I IFN production in plasmacytoid dendritic cells, Front. Immunol, vol.9, 2018. ,
URL : https://hal.archives-ouvertes.fr/hal-01772995
HCV glycoprotein E2 is a novel BDCA-2 ligand and acts as an inhibitor of IFN production by plasmacytoid dendritic cells, Blood, vol.120, pp.4544-4551, 2012. ,
URL : https://hal.archives-ouvertes.fr/hal-02507284
Regulation of TLR7/9 signaling in plasmacytoid dendritic cells, Protein Cell, vol.4, pp.40-52, 2013. ,
The multifaceted biology of plasmacytoid dendritic cells, Nat. Rev. Immunol, vol.15, pp.471-485, 2015. ,
Impaired Toll-like receptor 7 and 9 signaling: from chronic viral infections to cancer, Trends Immunol, vol.31, pp.391-397, 2010. ,
Expression and functionality of toll-and RIG-like receptors in HepaRG cells, J. Hepatol, vol.63, pp.1077-1085, 2015. ,
Interaction between toll-like receptor 9-CpG oligodeoxynucleotides and Hepatitis B Virus virions leads to entry inhibition in hepatocytes and reduction of alpha interferon production by plasmacytoid dendritic cells, Antimicrob. Agents Chemother, 2018. ,
URL : https://hal.archives-ouvertes.fr/inserm-01760408
Intratumoral immunotherapy with TLR7/8 agonist MEDI9197 modulates the tumor microenvironment leading to enhanced activity when combined with other immunotherapies, J. Immunother. Cancer, vol.7, 2019. ,
TLR agonist combinations that stimulate Th type I polarizing responses from human neonates, Innate Immun, vol.24, pp.240-251, 2018. ,
Dual TLR2 and TLR7 agonists as HIV latency-reversing agents, JCI Insight, 2018. ,
Pharmacokinetic and pharmacodynamic properties of GS-9620, a novel Toll-like receptor 7 agonist, demonstrate interferon-stimulated gene induction without detectable serum interferon at low oral doses, J. Pharmacol. Exp. Ther, vol.348, pp.96-105, 2014. ,
Hepatitis C virus fails to activate NF-kappaB signaling in plasmacytoid dendritic cells, J. Virol, vol.86, pp.1090-1096, 2011. ,
Transmitted/founder hepatitis C viruses induce cell-type-and genotype-specific differences in innate signaling within the liver, MBio, vol.6, 2015. ,
Dual role of the tyrosine kinase Syk in regulation of toll-like receptor signaling in plasmacytoid dendritic cells, PLoS ONE, vol.11, p.63, 2016. ,
URL : https://hal.archives-ouvertes.fr/inserm-01357267
Virus or TLR agonists induce TRAIL-mediated cytotoxic activity of plasmacytoid dendritic cells, J. Immunol, vol.176, pp.248-255, 2006. ,
URL : https://hal.archives-ouvertes.fr/inserm-00286442
Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848, Nat. Immunol, vol.3, p.499, 2002. ,
Molecular mechanisms of regulation of Toll-like receptor signaling, J. Leukoc. Biol, vol.100, pp.927-941, 2016. ,
IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors, Annu. Rev. Immunol, vol.23, pp.275-306, 2005. ,
TLR7 and TLR8 activate distinct pathways in monocytes during RNA virus infection, Sci. Signal, 2019. ,
, Scientific RepoRtS |, vol.10, p.12767, 2020.
Safety and efficacy of vesatolimod (GS-9620) in patients with chronic hepatitis B who are not currently on antiviral treatment, J. Viral. Hepat, vol.25, pp.1331-1340, 2018. ,
Safety, efficacy and pharmacodynamics of vesatolimod (GS-9620) in virally suppressed patients with chronic hepatitis B, J. Hepatol, vol.68, pp.431-440, 2018. ,
Safety, pharmacokinetics and pharmacodynamics of the oral toll-like receptor 7 agonist GS-9620 in treatment-naive patients with chronic hepatitis C, Antivir. Ther, vol.20, pp.699-708, 2015. ,
Clinical evaluation of CpG oligonucleotides as adjuvants for vaccines targeting infectious diseases and cancer, Vaccine, vol.32, pp.6377-6389, 2014. ,
Targeting of immune cells by dual TLR2/7 ligands suppresses features of allergic Th2 immune responses in mice, J. Immunol. Res, 2017. ,
PRMT5: a novel regulator of hepatitis B virus replication and an arginine methylase of HBV core, PLoS ONE, vol.12, p.82, 2017. ,
Metabolic capacities in cultured human hepatocytes obtained by a new isolating procedure from non-wedge small liver biopsies, Hum. Exp. Toxicol, vol.17, p.4, 1998. ,
URL : https://hal.archives-ouvertes.fr/hal-00502782
Hepatitis C virus is a weak inducer of interferon alpha in plasmacytoid dendritic cells in comparison with influenza and human herpesvirus type-1, PLoS ONE, vol.4, p.4319, 2009. ,