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Recommendations for ototoxicity surveillance for childhood, adolescent, and young adult cancer survivors: a report from the International Late Effects of Childhood Cancer Guideline Harmonization Group in collaboration with the PanCare Consortium

Eva Clemens 1, 2 Marry van den Heuvel-Eibrink 1 Renée Mulder 1, 3 Leontien Kremer 1, 3 Melissa Hudson 4, 5 Roderick Skinner 6 Louis Constine 7 Johnnie Bass 4 Claudia Kuehni 8 Thorsten Langer 9 Elvira van Dalen 1, 3 Edith Bardi 1 Nicolas-Xavier Bonne 10, 11 Penelope Brock 12 Beth Brooks 4, 13 Bruce Carleton 13 Eric Caron 4 Kay Chang 14 Karen Johnston 15 Kristin Knight 16 Paul Nathan 17 Etan Orgel 18, 19 Pinki Prasad 20, 21 Jan Rottenberg 22 Katrin Scheinemann 23, 24, 25 Andrica de Vries 1 Thomas Walwyn 26, 27 Annette Weiss 28 Antoinette Am Zehnhoff-Dinnesen 29 Richard Cohn 15, 30 Wendy Landier 31
Abstract : Childhood, adolescent, and young adult (CAYA) cancer survivors treated with platinum-based drugs, head or brain radiotherapy, or both have an increased risk of ototoxicity (hearing loss, tinnitus, or both). To ensure optimal care and reduce consequent problems—such as speech and language, social–emotional development, and learning difficulties—for these CAYA cancer survivors, clinical practice guidelines for monitoring ototoxicity are essential. The implementation of surveillance across clinical settings is hindered by differences in definitions of hearing loss, recommendations for surveillance modalities, and remediation. To address these deficiencies, the International Guideline Harmonization Group organised an international multidisciplinary panel, including 32 experts from ten countries, to evaluate the quality of evidence for ototoxicity following platinum-based chemotherapy and head or brain radiotherapy, and formulate and harmonise ototoxicity surveillance recommendations for CAYA cancer survivors.
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https://www.hal.inserm.fr/inserm-02941725
Contributor : Michel Salzet <>
Submitted on : Thursday, September 17, 2020 - 11:45:52 AM
Last modification on : Tuesday, July 6, 2021 - 5:12:02 PM

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Eva Clemens, Marry van den Heuvel-Eibrink, Renée Mulder, Leontien Kremer, Melissa Hudson, et al.. Recommendations for ototoxicity surveillance for childhood, adolescent, and young adult cancer survivors: a report from the International Late Effects of Childhood Cancer Guideline Harmonization Group in collaboration with the PanCare Consortium. The Lancet Oncology, 2019, 20 (1), pp.e29-e41. ⟨10.1016/S1470-2045(18)30858-1⟩. ⟨inserm-02941725⟩

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