Imaging challenges of immunotherapy and targeted therapy in patients with brain metastases: response, progression, and pseudoprogression - Archive ouverte HAL Access content directly
Journal Articles Neuro-Oncology Year : 2020

Imaging challenges of immunotherapy and targeted therapy in patients with brain metastases: response, progression, and pseudoprogression

(1, 2) , (2, 1) , (1) , (1) , (1) , (1) , (3) , (4) , (5, 6, 7, 8) , (7, 8) , (9, 10) , (1, 2) , (2, 11)
1
2
3
4
5
6
7
8
9
10
11

Abstract

The advent of immunotherapy using immune checkpoint inhibitors (ICIs) and targeted therapy (TT) has dramatically improved the prognosis of various cancer types. However, following ICI therapy or TT-either alone (especially ICI) or in combination with radiotherapy-imaging findings on anatomical contrast-enhanced MRI can be unpredictable and highly variable, and are often difficult to interpret regarding treatment response and outcome. This review aims at summarizing the imaging challenges related to TT and ICI monotherapy as well as combined with radiotherapy in patients with brain metastases, and to give an overview on advanced imaging techniques which potentially overcome some of these imaging challenges. Currently, major evidence suggests that imaging parameters especially derived from amino acid PET, perfusion-/diffusion-weighted MRI, or MR spectroscopy may provide valuable additional information for the differentiation of treatment-induced changes from brain metastases recurrence and the evaluation of treatment response.

Dates and versions

inserm-02941717 , version 1 (17-09-2020)

Identifiers

Cite

Norbert Galldiks, Martin Kocher, Garry Ceccon, Jan-Michael Werner, Anna Brunn, et al.. Imaging challenges of immunotherapy and targeted therapy in patients with brain metastases: response, progression, and pseudoprogression. Neuro-Oncology, 2020, 22 (1), pp.17-30. ⟨10.1093/neuonc/noz147⟩. ⟨inserm-02941717⟩

Collections

INSERM UNIV-LILLE
7 View
0 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More