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Glioblastoma in adults: a Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future directions

Patrick Wen 1, 2 Michael Weller 3, 4 Eudocia Quant Lee 1, 2 Brian Alexander 1, 2 Jill Barnholtz-Sloan 5 Floris Barthel 6 Tracy Batchelor 1, 2 Ranjit Bindra 7 Susan Chang 8 E Antonio Chiocca 1 Timothy Cloughesy 9 John Degroot 10 Evanthia Galanis 11 Mark Gilbert 12 Monika Hegi 13, 14 Craig Horbinski 15 Raymond Huang 16, 2 Andrew Lassman 17, 18 Emilie Le Rhun 19, 20, 21, 4 Michael Lim 22 Minesh Mehta 23 Ingo Mellinghoff 24 Giuseppe Minniti 25 David Nathanson 9 Michael Platten 26 Matthias Preusser 27 Patrick Roth 3, 4 Marc Sanson 28 David Schiff 29 Susan Short 30 Martin Taphoorn 31 Joerg-Christian Tonn 32 Jonathan Tsang 9 Roel Verhaak 6 Andreas von Deimling 26, 33 Wolfgang Wick 34 Gelareh Zadeh 35 David Reardon 1, 2 Kenneth Aldape 12 Martin van den Bent 36
Abstract : Glioblastomas are the most common form of malignant primary brain tumor and an important cause of morbidity and mortality. In recent years there have been important advances in understanding the molecular pathogenesis and biology of these tumors, but this has not translated into significantly improved outcomes for patients. In this consensus review from the Society for Neuro-Oncology (SNO) and the European Association of Neuro-Oncology (EANO), the current management of isocitrate dehydrogenase wildtype (IDHwt) glioblastomas will be discussed. In addition, novel therapies such as targeted molecular therapies, agents targeting DNA damage response and metabolism, immunotherapies, and viral therapies will be reviewed, as well as the current challenges and future directions for research.
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https://www.hal.inserm.fr/inserm-02941679
Contributor : Michel Salzet Connect in order to contact the contributor
Submitted on : Thursday, September 17, 2020 - 11:18:42 AM
Last modification on : Friday, December 3, 2021 - 12:14:00 PM

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Patrick Wen, Michael Weller, Eudocia Quant Lee, Brian Alexander, Jill Barnholtz-Sloan, et al.. Glioblastoma in adults: a Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future directions. Neuro-Oncology, Oxford University Press (OUP), 2020, 22 (8), pp.1073-1113. ⟨10.1093/neuonc/noaa106⟩. ⟨inserm-02941679⟩

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