Journal articles

Glioblastoma in adults: a Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future directions

Patrick y Wen ^{1, 2} Michael Weller ^{3, 4} Eudocia Quant Lee ^{1, 2} Brian M Alexander ^{1, 2} Jill S Barnholtz-Sloan ⁵ Floris P Barthel ⁶ Tracy T Batchelor ^{1, 2} Ranjit S Bindra ⁷ Susan M Chang ⁸ E Antonio Chiocca ¹ Timothy F Cloughesy ⁹ John F Degroot ¹⁰ Evanthia Galanis ¹¹ Mark R Gilbert ¹² Monika E Hegi ^{13, 14} Craig Horbinski ¹⁵ Raymond y Huang ^{16, 2} Andrew B Lassman ^{17, 18} Emilie Le Rhun ^{19, 20, 21, 4} Michael Lim ²² Minesh P Mehta ²³ Ingo K Mellinghoff ²⁴ Giuseppe Minniti ²⁵ David Nathanson ⁹ Michael Platten ²⁶ Matthias Preusser ²⁷ Patrick Roth ^{3, 4} Marc Sanson ²⁸ David Schiff ²⁹ Susan C Short ³⁰ Martin J.B Taphoorn ³¹ Joerg-Christian Tonn ³² Jonathan Tsang ⁹ Roel G.W Verhaak ⁶ Andreas von Deimling ^{26, 33} Wolfgang Wick ³⁴ Gelareh Zadeh ³⁵ David A Reardon ^{1, 2} Kenneth D Aldape ¹² Martin J van den Bent ³⁶

1 Dana-Farber Cancer Institute [Boston]

2 BWH - Brigham & Women’s Hospital [Boston]

3 University hospital of Zurich [Zurich]

4 UZH - Universität Zürich [Zürich] = University of Zurich

5 Case Western Reserve University [Cleveland]

6 JAX - The Jackson Laboratory [Bar Harbor]

7 YSM - Yale School of Medicine [New Haven, Connecticut]

8 UCSF - University of California [San Francisco]

9 UCLA - University of California [Los Angeles]

10 MD Anderson Cancer Center [Houston]

11 Mayo Clinic [Rochester]

12 NCI-NIH - National Cancer Institute [Bethesda]

13 UNIL - Université de Lausanne

14 CHUV - Centre Hospitalier Universitaire Vaudois [Lausanne]

15 Northwestern University Feinberg School of Medicine

16 HMS - Harvard Medical School [Boston]

17 New York Presbyterian Hospital

18 CUIMC - Columbia University Irving Medical Center

19 PRISM - Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U 1192

20 CHRU Lille - Centre Hospitalier Régional Universitaire [Lille]

21 UNICANCER/Lille - Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille]

22 Johns Hopkins University School of Medicine [Baltimore]

23 Miami Cancer Institute [Florida]

24 Memorial Sloane Kettering Cancer Center [New York]

25 UNISI - Università degli Studi di Siena = University of Siena

26 Heidelberg University

27 Medizinische Universität Wien = Medical University of Vienna

28 ICM - Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute

29 University of Virginia [Charlottesville]

30 University of Leeds

31 Leiden University Medical Center (LUMC)

32 LMU - Ludwig Maximilian University [Munich]

33 DKFZ - German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg]

34 Heidelberg University Hospital [Heidelberg]

35 Princess Margaret Cancer Centre [Toronto, Canada]

36 Erasmus MC - Erasmus University Medical Center [Rotterdam]

Abstract : Glioblastomas are the most common form of malignant primary brain tumor and an important cause of morbidity and mortality. In recent years there have been important advances in understanding the molecular pathogenesis and biology of these tumors, but this has not translated into significantly improved outcomes for patients. In this consensus review from the Society for Neuro-Oncology (SNO) and the European Association of Neuro-Oncology (EANO), the current management of isocitrate dehydrogenase wildtype (IDHwt) glioblastomas will be discussed. In addition, novel therapies such as targeted molecular therapies, agents targeting DNA damage response and metabolism, immunotherapies, and viral therapies will be reviewed, as well as the current challenges and future directions for research.

Keywords : clinical trials diagnosis glioblastoma therapy

Document type :

Journal articles

Domain :

Life Sciences [q-bio]

Complete list of metadata

https://www.hal.inserm.fr/inserm-02941679
Contributor : Michel SALZET Connect in order to contact the contributor
Submitted on : Thursday, September 17, 2020 - 11:18:42 AM
Last modification on : Friday, May 20, 2022 - 11:06:46 AM