Glioblastoma in adults: a Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future directions - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles Neuro-Oncology Year : 2020

Glioblastoma in adults: a Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future directions

1 Dana-Farber Cancer Institute [Boston]
2 BWH - Brigham & Women’s Hospital [Boston]
3 University hospital of Zurich [Zurich]
4 UZH - Universität Zürich [Zürich] = University of Zurich
5 Case Western Reserve University [Cleveland]
6 JAX - The Jackson Laboratory [Bar Harbor]
7 YSM - Yale School of Medicine [New Haven, Connecticut]
8 UC San Francisco - University of California [San Francisco]
9 UCLA - University of California [Los Angeles]
10 MD Anderson Cancer Center [Houston]
11 Mayo Clinic [Rochester]
12 NCI-NIH - National Cancer Institute [Bethesda]
13 UNIL - Université de Lausanne = University of Lausanne
14 CHUV - Centre Hospitalier Universitaire Vaudois [Lausanne]
15 Northwestern University Feinberg School of Medicine
16 HMS - Harvard Medical School [Boston]
17 New York Presbyterian Hospital
18 CUIMC - Columbia University Irving Medical Center
19 PRISM - Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U 1192
20 CHRU Lille - Centre Hospitalier Régional Universitaire [Lille]
21 UNICANCER/Lille - Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille]
22 Johns Hopkins University School of Medicine [Baltimore]
23 Miami Cancer Institute [Florida]
24 Memorial Sloane Kettering Cancer Center [New York]
25 UNISI - Università degli Studi di Siena = University of Siena
26 Heidelberg University
27 Medizinische Universität Wien = Medical University of Vienna
28 ICM - Institut du Cerveau = Paris Brain Institute
29 University of Virginia
30 University of Leeds
31 Leiden University Medical Center (LUMC)
32 LMU - Ludwig Maximilian University [Munich]
33 DKFZ - German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg]
34 Heidelberg University Hospital [Heidelberg]
35 Princess Margaret Cancer Centre [Toronto, Canada]
36 Erasmus MC - Erasmus University Medical Center [Rotterdam]

Abstract

Glioblastomas are the most common form of malignant primary brain tumor and an important cause of morbidity and mortality. In recent years there have been important advances in understanding the molecular pathogenesis and biology of these tumors, but this has not translated into significantly improved outcomes for patients. In this consensus review from the Society for Neuro-Oncology (SNO) and the European Association of Neuro-Oncology (EANO), the current management of isocitrate dehydrogenase wildtype (IDHwt) glioblastomas will be discussed. In addition, novel therapies such as targeted molecular therapies, agents targeting DNA damage response and metabolism, immunotherapies, and viral therapies will be reviewed, as well as the current challenges and future directions for research.

Dates and versions

inserm-02941679 , version 1 (17-09-2020)

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Patrick y Wen, Michael Weller, Eudocia Quant Lee, Brian M Alexander, Jill S Barnholtz-Sloan, et al.. Glioblastoma in adults: a Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future directions. Neuro-Oncology, 2020, 22 (8), pp.1073-1113. ⟨10.1093/neuonc/noaa106⟩. ⟨inserm-02941679⟩
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