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Water-Soluble Aza-BODIPYs: Biocompatible Organic Dyes for High Contrast In Vivo NIR-II Imaging

Abstract : A simple NIR-II emitting water-soluble system has been developed and applied in vitro and in vivo. In vitro, the fluorophore quickly accumulated in 2D and 3D cell cultures and rapidly reached the tumor in rodents, showing high NIR-II contrast for up to 1 week. This very efficient probe possesses all the qualities necessary for translation to the clinic as well as for the development of NIR-II emitting materials.
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https://www.hal.inserm.fr/inserm-02941480
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Submitted on : Thursday, September 17, 2020 - 9:51:16 AM
Last modification on : Monday, March 1, 2021 - 10:36:01 PM
Long-term archiving on: : Thursday, December 3, 2020 - 9:06:52 AM

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Amélie Godard, Ghadir Kalot, Jacques Pliquett, Benoit Busser, Xavier Le Guével, et al.. Water-Soluble Aza-BODIPYs: Biocompatible Organic Dyes for High Contrast In Vivo NIR-II Imaging. Bioconjugate Chemistry, American Chemical Society, 2020, 31 (4), pp.1088-1092. ⟨10.1021/acs.bioconjchem.0c00175⟩. ⟨inserm-02941480⟩

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