J. Kang, M. M. Lim, and R. J. Bateman, Amyloid-? Dynamics are Regulated by Orexin 124 and the Sleep-Wake Cycle, Science, vol.326, pp.1005-1007, 2009.

J. K. Holth, S. K. Fritschi, and C. Wang, The sleep-wake cycle regulates brain interstitial 126

, mice and CSF tau in humans, vol.363, pp.880-884, 2019.

L. Xie, H. Kang, and Q. Xu, Sleep Drives Metabolite Clearance from the Adult Brain, Science, vol.342, pp.373-377, 2013.

C. V. Senaratna, J. L. Perret, and C. J. Lodge, Prevalence of obstructive sleep apnea in the 130 general population: A systematic review, Sleep Med. Rev, vol.34, pp.70-81, 2017.

Y. Leng, C. T. Mcevoy, and I. E. Allen, Association of Sleep-Disordered Breathing With 132

, Cognitive Function and Risk of Cognitive Impairment: A Systematic Review, p.133

. Meta-analysis, JAMA Neurol, vol.74, pp.1237-1245, 2017.

C. André, S. Rehel, and E. Kuhn, Association of Sleep-Disordered Breathing With 135

, Alzheimer Disease Biomarkers in Community-Dwelling Older Adults: A Secondary 136

, Analysis of a Randomized Clinical Trial, JAMA Neurol, pp.200311-137, 2020.

G. Poisnel, E. Arenaza-urquijo, and F. Collette, The Age-Well randomized controlled 138 trial of the Medit-Ageing European project: Effect of meditation or foreign language 139 training on brain and mental health in older adults, Transl. Res

, Clin. Interv, vol.4, pp.714-723, 2018.

L. Li, X. Zhang, and D. Yang, Hypoxia increases Abeta generation by altering beta-142 and gamma-cleavage of APP, Neurobiol. Aging, vol.30, pp.1091-1099, 2009.

A. W. Bero, P. Yan, and J. H. Roh, Neuronal activity regulates the regional vulnerability 144 to amyloid-? deposition, Nat. Neurosci, vol.14, pp.750-756, 2011.

J. W. Kinney, S. M. Bemiller, and A. S. Murtishaw, Inflammation as a central mechanism 146

, Alzheimer's disease, Transl. Res. Clin. Interv, vol.4, pp.575-147, 2018.