The multiverse nature of epithelial to mesenchymal transition - Inserm - Institut national de la santé et de la recherche médicale Accéder directement au contenu
Article Dans Une Revue Seminars in Cancer Biology Année : 2019

The multiverse nature of epithelial to mesenchymal transition

Résumé

The epithelial mesenchymal transition (EMT) program is defined as a cellular transition from an epithelial to a mesenchymal state. This process occurs to provide the cell with new phenotypic assets and new skills to perform complex processes. EMT is regulated at multilayer levels, including transcriptional control of gene expression, regulation of RNA splicing, and translational/post-translational control. Although transcriptional regulation by EMT-inducing transcription factors (EMT-TFs), including Zeb, Snail and Slug members, is generally considered the master step in this process, emerging data indicate that all these regulatory networks may have a role in the control of EMT. There is a sort of parallelism between the biological and still unrevealed EMT complexity and the cosmological hypothesis that sustains the universe may exist as a multiverse. The presence of different EMT transition states together with the occurrence of multiple layers of regulation support the idea that EMT is just one on many out there. Is the activation of a single layer of regulation sufficient to initiate the whole EMT program? Can we postulate the activation of different EMT "dimensions"? If we think about these layers as multiple separate "universes", various scenarios can be revealed.
Fichier sous embargo
Fichier sous embargo
Date de visibilité indéterminée
Loading...

Dates et versions

inserm-02940760 , version 1 (16-09-2020)

Identifiants

Citer

Pasquale Simeone, Marco Trerotola, Julien Franck, Tristan Cardon, Marco Marchisio, et al.. The multiverse nature of epithelial to mesenchymal transition. Seminars in Cancer Biology, 2019, 58, pp.1-10. ⟨10.1016/j.semcancer.2018.11.004⟩. ⟨inserm-02940760⟩

Collections

INSERM UNIV-LILLE
27 Consultations
1 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More