Glioblastoma quo vadis : Will migration and invasiveness reemerge as therapeutic targets? - Archive ouverte HAL Access content directly
Journal Articles Cancer Treatment Reviews Year : 2018

Glioblastoma quo vadis : Will migration and invasiveness reemerge as therapeutic targets?

(1) , (2, 3) , (4) , (5, 6)
1
2
3
4
5
6

Abstract

Purpose: The purpose of the current review is to highlight, on one hand, the fact that the migratory pattern of glioma cells is the major obstacle to combat them with chemotherapy, and on the other one, the new treatment strategies to overcome this obstacle. Methods: This review surveys several membrane and extracellular molecules involved in glioma cell migration, invasiveness and resistance to apoptosis. Results: This review focuses on signaling pathways implicated in the positive regulation of glioblastoma cell migration, including glutamate and ion channel networks, microtubes and membrane-derived extracellular vesicles (EV) containing microRNAs. Glioma cells release glutamate to the extracellular matrix, inducing neuronal cell death, which may facilitate glioma growth and invasion. Glioma cell migration and invasion are further facilitated through ion channels and transporters that modify cellular volume. Microtubes and EV promote connections and communication among glioma cells and with the microenvironment and are associated with progression and resistance to therapy. Potential therapies linked to these pathways for glioblastoma are being developed. Conclusion: Our view is evolving from an intracellular view of the complex intracellular signaling pathways to one of orchestral machinery, including connections between heterogeneous tumoral and nontumoral cells and with the microenvironment through channels, microtubes, and extracellular miRNA, generating different signals at different times. All of these elements give rise to a new perspective for the treatment of glioblastoma.
Fichier principal
Vignette du fichier
1-s2.0-S0305737218301117-main.pdf (1.26 Mo) Télécharger le fichier
Origin : Publication funded by an institution
Loading...

Dates and versions

inserm-02940699 , version 1 (16-09-2020)

Identifiers

Cite

Florence Lefranc, Emilie Le Rhun, Robert Kiss, Michael Weller. Glioblastoma quo vadis : Will migration and invasiveness reemerge as therapeutic targets?. Cancer Treatment Reviews, 2018, 68, pp.145-154. ⟨10.1016/j.ctrv.2018.06.017⟩. ⟨inserm-02940699⟩

Collections

INSERM UNIV-LILLE
9 View
29 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More