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The Evolving Landscape of Brain Metastasis

Abstract : Metastasis, involving the spread of systemic cancer to the brain, results in neurologic disability and death. Current treatments are largely palliative in nature; improved therapeutic approaches represent an unmet clinical need. However, recent experimental and clinical advances challenge the bleak long-term outcome of this disease. Encompassing key recent findings in epidemiology, genetics, microenvironment, leptomeningeal disease, neurocognition, targeted therapy, immunotherapy, and prophylaxis, we review preclinical and clinical studies to provide a comprehensive picture of contemporary research and the management of secondary brain tumors.
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https://www.hal.inserm.fr/inserm-02940674
Contributor : Michel Salzet <>
Submitted on : Wednesday, September 16, 2020 - 2:31:04 PM
Last modification on : Wednesday, March 17, 2021 - 2:32:03 PM

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Manuel Valiente, Manmeet Ahluwalia, Adrienne Boire, Priscilla Brastianos, Sarah Goldberg, et al.. The Evolving Landscape of Brain Metastasis. Trends in Cancer, Cell Press, 2018, 4 (3), pp.176-196. ⟨10.1016/j.trecan.2018.01.003⟩. ⟨inserm-02940674⟩

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