Skip to Main content Skip to Navigation
Journal articles

Dynamic contrast-enhanced MR imaging pharmacokinetic parameters as predictors of treatment response of brain metastases in patients with lung cancer

Abstract : Objectives: To determine the diagnostic accuracy of pharmacokinetic parameters measured by dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) in predicting the response of brain metastases to antineoplastic therapy in patients with lung cancer. Methods: Forty-four consecutive patients with lung cancer, harbouring 123 newly diagnosed brain metastases prospectively underwent conventional 3-T MRI at baseline (within 1 month before treatment), during the early (7-10 weeks) and midterm (5-7 months) post-treatment period. An additional DCE MRI sequence was performed during baseline and early post-treatment MRI to evaluate baseline pharmacokinetic parameters (K trans, k ep, v e, v p) and their early variation (∆K trans, ∆k ep, ∆v e, ∆v p). The objective response was judged by the volume variation of each metastasis from baseline to midterm MRI. ROC curve analysis determined the best DCE MRI parameter to predict the objective response. Results: Baseline DCE MRI parameters were not associated with the objective response. Early ∆K trans, ∆v e and ∆v p were significantly associated with the objective response (p = 0.02, p = 0.001 and p = 0.02, respectively). The best predictor of objective response was ∆v e with an area under the curve of 0.93 [95% CI = 0.87, 0.99]. Conclusions: DCE MRI and early ∆v e may be a useful tool to predict the objective response of brain metastases in patients with lung cancer. Key points: • DCE MRI could predict the response of brain metastases from lung cancer • ∆v e was the best predictor of response • DCE MRI could be used to individualize patients' follow-up.
Document type :
Journal articles
Complete list of metadata

https://www.hal.inserm.fr/inserm-02940549
Contributor : Michel Salzet Connect in order to contact the contributor
Submitted on : Wednesday, September 16, 2020 - 1:13:27 PM
Last modification on : Wednesday, March 17, 2021 - 2:32:03 PM

Identifiers

Collections

Citation

Grégory Kuchcinski, Emilie Le Rhun, Alexis Cortot, Elodie Drumez, Romain Duhal, et al.. Dynamic contrast-enhanced MR imaging pharmacokinetic parameters as predictors of treatment response of brain metastases in patients with lung cancer. European Radiology, Springer Verlag, 2017, 27 (9), pp.3733-3743. ⟨10.1007/s00330-017-4756-5⟩. ⟨inserm-02940549⟩

Share

Metrics

Record views

35