Diagnosis and treatment of brain metastases from solid tumors: guidelines from the European Association of Neuro-Oncology (EANO)
Riccardo Soffietti
(1)
,
Ufuk Abacioglu
(2)
,
Brigitta Baumert
(3)
,
Stephanie E Combs
(4)
,
Sara Kinhult
(5)
,
Johan M Kros
(6)
,
Christine Marosi
(7)
,
Philippe Metellus
(7, 8)
,
Alexander Radbruch
(9)
,
Salvador S Villa Freixa
(10)
,
Michael Brada
(11)
,
Carmine M Carapella
(12)
,
Matthias Preusser
(13)
,
Emilie Le Rhun
(14)
,
Roberta Rudà
(1)
,
Joerg C Tonn
(15)
,
Damien C Weber
(16)
,
Michael Weller
(17)
1
City of Health and Science University Hospital [Turin, Italy]
2 Neolife Medical Center [Istanbul]
3 MediClin Robert-Janker-Klinik [Bonn]
4 Department of Innovative Radiation Oncology and Radiation Sciences [Munich]
5 Skane University Hospital [Lund]
6 Erasmus MC Cancer Institute, Rotterdam
7 Medizinische Universität Wien = Medical University of Vienna
8 Hôpital Privé Clairval [Marseille]
9 DKFZ - German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg]
10 Hospital Universitari Germans Trias I Pujol [Badalona]
11 Department of Molecular and Clinical Cancer Medicine & Radiation Oncology [Liverpool]
12 Regina Elena National Cancer Institute [Rome]
13 University of Vienna [Vienna]
14 CHRU Lille - Centre Hospitalier Régional Universitaire [CHU Lille]
15 LMU - Ludwig Maximilian University [Munich] = Ludwig Maximilians Universität München
16 PSI - Paul Scherrer Institute
17 University hospital of Zurich [Zurich]
2 Neolife Medical Center [Istanbul]
3 MediClin Robert-Janker-Klinik [Bonn]
4 Department of Innovative Radiation Oncology and Radiation Sciences [Munich]
5 Skane University Hospital [Lund]
6 Erasmus MC Cancer Institute, Rotterdam
7 Medizinische Universität Wien = Medical University of Vienna
8 Hôpital Privé Clairval [Marseille]
9 DKFZ - German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg]
10 Hospital Universitari Germans Trias I Pujol [Badalona]
11 Department of Molecular and Clinical Cancer Medicine & Radiation Oncology [Liverpool]
12 Regina Elena National Cancer Institute [Rome]
13 University of Vienna [Vienna]
14 CHRU Lille - Centre Hospitalier Régional Universitaire [CHU Lille]
15 LMU - Ludwig Maximilian University [Munich] = Ludwig Maximilians Universität München
16 PSI - Paul Scherrer Institute
17 University hospital of Zurich [Zurich]
Philippe Metellus
- Fonction : Auteur
- PersonId : 768798
- ORCID : 0000-0001-8987-8116
Michael Weller
- Fonction : Auteur
- PersonId : 781346
- ORCID : 0000-0002-1748-174X
- IdRef : 194357112
Résumé
The management of patients with brain metastases has become a major issue due to the increasing frequency and complexity of the diagnostic and therapeutic approaches. In 2014, the European Association of Neuro-Oncology (EANO) created a multidisciplinary Task Force to draw evidence-based guidelines for patients with brain metastases from solid tumors. Here, we present these guidelines, which provide a consensus review of evidence and recommendations for diagnosis by neuroimaging and neuropathology, staging, prognostic factors, and different treatment options. Specifically, we addressed options such as surgery, stereotactic radiosurgery/stereotactic fractionated radiotherapy, whole-brain radiotherapy, chemotherapy and targeted therapy (with particular attention to brain metastases from non-small cell lung cancer, melanoma and breast and renal cancer), and supportive care.