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Aspects immunologiques du cancer de l’ovaire : perspectives thérapeutiques

Abstract : Ovarian cancer is recognized by the immunological system of its host. Initially, it is effective to destroy and eliminate the cancer. But gradually, resistant tumor cells more aggressive and those able to protect themselves by inducing immune tolerance will be selected. Immunotherapy to be effective should consider both components of immune response with an action on cytotoxic immune effectors and action on tolerance mechanisms. The manipulations of the immune system should be cautious, because the immune effects are not isolated. A theoretically efficient handling may simultaneously cause an adverse effect which was not envisaged and could neutralize the benefits of treatment. Knowledge of tolerance mechanisms set up by the tumor is for the clinician a prerequisite before they prescribe these treatments. For each cancer, the knowledge of its immunological status is a prerequisite to propose adapted immunological therapies.
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https://www.hal.inserm.fr/inserm-02940288
Contributor : Michel Salzet <>
Submitted on : Wednesday, September 16, 2020 - 11:13:36 AM
Last modification on : Monday, September 21, 2020 - 1:30:40 PM

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M. Nayama, P. Collinet, Michel Salzet, D. Vinatier. Aspects immunologiques du cancer de l’ovaire : perspectives thérapeutiques. Journal de Gynécologie Obstétrique et Biologie de la Reproduction, Elsevier Masson, 2016, 45 (9), pp.1020-1036. ⟨10.1016/j.jgyn.2016.05.005⟩. ⟨inserm-02940288⟩

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