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Brain Substrates of Time-Based Prospective Memory Decline in Aging: A Voxel-Based Morphometry and Diffusion Tensor Imaging Study: Neural substrates of prospective memory decline in aging

Abstract : Time-based prospective memory (TBPM) allows us to remember to perform intended actions at a specific time in the future. TBPM is sensitive to the effects of age, but the neural substrates of this decline are still poorly understood. The aim of the present study was thus to better characterize the brain substrates of the age-related decline in TBPM, focusing on macrostructural gray-matter and microstructural white-matter integrity. We administered a TBPM task to 22 healthy young (26 ± 5.2 years) and 23 older (63 ± 5.9 years) participants, who also underwent volumetric magnetic resonance imaging and diffusion tensor imaging scans. Neuroimaging analyses revealed lower gray-matter volumes in several brain areas in older participants, but these did not correlate with TBPM performance. By contrast, an age-related decline in fractional anisotropy in several white-matter tracts connecting frontal and occipital regions did correlate with TBPM performance, while there was no significant correlation in healthy young subjects. According to the literature, these tracts are connected to the anterior prefrontal cortex and the thalamus, two structures involved in TBPM. These results confirm the view that a disconnection process occurs in aging and contributes to cognitive decline.
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https://www.hal.inserm.fr/inserm-02933201
Contributor : Francis Eustache <>
Submitted on : Tuesday, September 8, 2020 - 11:23:18 AM
Last modification on : Friday, September 18, 2020 - 2:35:05 PM

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  • HAL Id : inserm-02933201, version 1

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Alexandrine Morand, Shailendra Segobin, Grégory Lecouvey, Julie Gonneaud, Francis Eustache, et al.. Brain Substrates of Time-Based Prospective Memory Decline in Aging: A Voxel-Based Morphometry and Diffusion Tensor Imaging Study: Neural substrates of prospective memory decline in aging. Cerebral Cortex, Oxford University Press (OUP), In press. ⟨inserm-02933201⟩

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