Skip to Main content Skip to Navigation
Journal articles

PPARβ/δ-dependent MSC metabolism determines their immunoregulatory properties

Abstract : Mesenchymal stem cell (MSC)-based therapy is being increasingly considered a powerful opportunity for several disorders based on MSC immunoregulatory properties. Nonetheless, MSC are versatile and plastic cells that require an efficient control of their features and functions for their optimal use in clinic. Recently, we have shown that PPARβ/δ is pivotal for MSC immunoregulatory and therapeutic functions. However, the role of PPARβ/δ on MSC metabolic activity and the relevance of PPARβ/δ metabolic control on MSC immunosuppressive properties have never been addressed. Here, we demonstrate that PPARβ/δ deficiency forces MSC metabolic adaptation increasing their glycolytic activity required for their immunoregulatory functions on Th1 and Th17 cells. Additionally, we show that the inhibition of the mitochondrial production of ATP in MSC expressing PPARβ/δ, promotes their metabolic switch towards aerobic glycolysis to stably enhance their immunosuppressive capacities significantly. Altogether, these data demonstrate that PPARβ/δ governs the immunoregulatory potential of MSC by dictating their metabolic reprogramming and pave the way for enhancing MSC immunoregulatory properties and counteracting their versatility.
Document type :
Journal articles
Complete list of metadatas

Cited literature [18 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-02925972
Contributor : Myriam Bodescot <>
Submitted on : Monday, August 31, 2020 - 11:13:22 AM
Last modification on : Tuesday, September 1, 2020 - 3:30:34 AM

File

s41598-020-68347-x.pdf
Publication funded by an institution

Identifiers

Collections

Citation

Rafael Contreras-Lopez, Roberto Elizondo-Vega, Maria Torres, Ana Vega-Letter, Noymar Luque-Campos, et al.. PPARβ/δ-dependent MSC metabolism determines their immunoregulatory properties. Scientific Reports, Nature Publishing Group, 2020, 10 (1), pp.11423. ⟨10.1038/s41598-020-68347-x⟩. ⟨inserm-02925972⟩

Share

Metrics

Record views

38

Files downloads

22