Cross-reactivity between tumor MHC class I-restricted antigens and an enterococcal bacteriophage

Aurélie Fluckiger; Romain Daillere; Mohamed Sassi; Barbara S Sixt; Peng Liu; Friedemann Loos; Corentin Richard; Catherine Rabu; Maryam Tidjani; Anne-Gaëlle Goubet; Fabien Lemaitre; Gladys Ferrere; Lisa Derosa; Connie Duong; Meriem Messaoudene; Andréanne Gagné; Philippe Joubert; Luisa de Sordi; Laurent Debarbieux; Sylvain Simon; Clara-Maria Scarlata; Maha Ayyoub; Belinda Palermo; Francesco Facciolo; Romain Boidot; Richard Wheeler; Ivo Gomperts Boneca; Zsofia Sztupinszki; Krisztian Papp; Istvan Csabai; Edoardo Pasolli; Nicola Segata; Carlos López-Otín; Zoltan Szallasi; Fabrice Andre; Valerio Iebba; Valentin Quiniou; David Klatzmann; Jacques Boukhalil; Saber Khelaifia; Didier Raoult; Laurence Albiges; Bernard Escudier; Alexander M Eggermont; Fathia Mami-Chouaib; Paola Nistico; François Ghiringhelli; Bertrand Routy; Nathalie Labarrière; Vincent Cattoir; Guido E Kroemer; Laurence Zitvogel

doi:10.1126/science.aax0701

Journal Articles Science Year : 2020

Cross-reactivity between tumor MHC class I-restricted antigens and an enterococcal bacteriophage

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Aurélie Fluckiger

Function : Author

Institut Gustave Roussy

Immunologie anti-tumorale et immunothérapie des cancers

Romain Daillere

Function : Author

Institut Gustave Roussy

Immunologie anti-tumorale et immunothérapie des cancers

Mohamed Sassi

Function : Author

ARN régulateurs bactériens et médecine

Barbara S Sixt

Function : Author

Umeå University

Institut Gustave Roussy

Centre de Recherche des Cordeliers

Peng Liu

Function : Author
PersonId : 1026634

Institut Gustave Roussy

Centre de Recherche des Cordeliers

Friedemann Loos

Function : Author

Institut Gustave Roussy

Centre de Recherche des Cordeliers

Corentin Richard

Function : Author
PersonId : 780821
ORCID : 0000-0001-9732-0219

Centre d'oncologie et de radiothérapie du parc [Dijon]

Institut de médecine génomique et d’immunothérapie (Genomic and Immunotherapy Medical Institute)

Catherine Rabu

Function : Author
PersonId : 181681
IdHAL : catherine-rabu
ORCID : 0000-0001-8405-2809
IdRef : 061742732

Anti-Tumor Immunosurveillance and Immunotherapy

Maryam Tidjani

Function : Author

Institut Gustave Roussy

Immunologie anti-tumorale et immunothérapie des cancers

Microbes évolution phylogénie et infections

Anne-Gaëlle Goubet

Function : Author
PersonId : 802175
ORCID : 0000-0003-3431-3067
IdRef : 22578954X

Institut Gustave Roussy

Immunologie anti-tumorale et immunothérapie des cancers

Fabien Lemaitre

Function : Author

Institut Gustave Roussy

Gladys Ferrere

Function : Author
PersonId : 779155
ORCID : 0000-0001-6103-9185

Institut Gustave Roussy

Immunologie anti-tumorale et immunothérapie des cancers

Lisa Derosa

Function : Author
PersonId : 786395
ORCID : 0000-0003-0527-2964

Institut Gustave Roussy

Immunologie anti-tumorale et immunothérapie des cancers

Université Paris-Saclay

Connie Duong

Function : Author
PersonId : 795060
ORCID : 0000-0002-9067-8557

Institut Gustave Roussy

Immunologie anti-tumorale et immunothérapie des cancers

Meriem Messaoudene

Function : Author

Institut Universitaire de Cardiologie et de Pneumologie de Québec

Andréanne Gagné

Function : Author

Institut Universitaire de Cardiologie et de Pneumologie de Québec

Philippe Joubert

Function : Author

Institut Universitaire de Cardiologie et de Pneumologie de Québec

Luisa de Sordi

Function : Author

Institut Pasteur [Paris]

Centre de Recherche Saint-Antoine

Laurent Debarbieux

Function : Author
PersonId : 14176
IdHAL : laurent-debarbieux
ORCID : 0000-0001-6875-5758
IdRef : 075090422

Institut Pasteur [Paris]

Sylvain Simon

Function : Author

Anti-Tumor Immunosurveillance and Immunotherapy

Clara-Maria Scarlata

Function : Author
PersonId : 797975
ORCID : 0000-0003-3429-2825

Centre de Recherches en Cancérologie de Toulouse

Maha Ayyoub

Function : Author
PersonId : 773870
ORCID : 0000-0003-2022-0898

Centre de Recherches en Cancérologie de Toulouse

Belinda Palermo

Function : Author

National Cancer Institute Regina Elena [Rome, Italy]

Francesco Facciolo

Function : Author

National Cancer Institute Regina Elena [Rome, Italy]

Romain Boidot

Function : Author

Centre Régional de Lutte contre le cancer Georges-François Leclerc [Dijon]

Richard Wheeler

Function : Author
PersonId : 743047
IdHAL : richard-wheeler
ORCID : 0000-0002-9249-2377

Institut Pasteur [Paris]

Ivo Gomperts Boneca

Function : Author
PersonId : 759018
ORCID : 0000-0001-8122-509X
IdRef : 150628218

Institut Pasteur [Paris]

Zsofia Sztupinszki

Function : Author

Boston Children's Hospital

Krisztian Papp

Function : Author

Eötvös Loránd University

Istvan Csabai

Function : Author

Eötvös Loránd University

Edoardo Pasolli

Function : Author
PersonId : 1013425

University of Trento [Trento]

Nicola Segata

Function : Author
PersonId : 793997
ORCID : 0000-0002-1583-5794

University of Trento [Trento]

Carlos López-Otín

Function : Author

Centre de Recherche des Cordeliers

Universidad de Oviedo [Oviedo]

Zoltan Szallasi

Function : Author
PersonId : 763125
ORCID : 0000-0001-5395-7509
IdRef : 110262344

Boston Children's Hospital

Fabrice Andre

Function : Author

Institut Gustave Roussy

Valerio Iebba

Function : Author
PersonId : 802176
ORCID : 0000-0002-0716-306X

Institut Gustave Roussy

Valentin Quiniou

Function : Author
PersonId : 784427
ORCID : 0000-0002-0792-341X
IdRef : 19241173X

Centre d'investigation clinique Biothérapie [CHU Pitié-Salpêtrière]

David Klatzmann

Function : Author
PersonId : 757052
ORCID : 0000-0002-0054-3422
IdRef : 069959846

Centre d'investigation clinique Biothérapie [CHU Pitié-Salpêtrière]

Jacques Boukhalil

Function : Author

Microbes évolution phylogénie et infections

Saber Khelaifia

Function : Author
PersonId : 767187
ORCID : 0000-0002-9303-3893

Microbes évolution phylogénie et infections

Didier Raoult

Function : Author
PersonId : 8465
IdHAL : didier-raoult
ORCID : 0000-0002-0633-5974
IdRef : 035496169

Microbes évolution phylogénie et infections

Laurence Albiges

Function : Author

Institut Gustave Roussy

Bernard Escudier

Function : Author

Institut Gustave Roussy

Alexander M Eggermont

Function : Author

Institut Gustave Roussy

Fathia Mami-Chouaib

Function : Author

Immunologie intégrative des tumeurs et immunothérapie des cancers

Paola Nistico

Function : Author

National Cancer Institute Regina Elena [Rome, Italy]

François Ghiringhelli

Function : Author
PersonId : 756197
ORCID : 0000-0002-5465-8305

Centre Régional de Lutte contre le cancer Georges-François Leclerc [Dijon]

Bertrand Routy

Function : Author
PersonId : 780259
ORCID : 0000-0003-1955-9149

Centre Hospitalier de l'Université de Montréal

Nathalie Labarrière

Function : Author
PersonId : 182569
IdHAL : nathalie-labarriere
ORCID : 0000-0002-1407-6546
IdRef : 127025154

Anti-Tumor Immunosurveillance and Immunotherapy

Vincent Cattoir

Function : Author

Centre National de Référence de la Résistance aux Antibiotiques [CHU Rennes]

Guido E Kroemer

Function : Author

Institut Gustave Roussy

Institut Universitaire de France

Laurence Zitvogel

Function : Author

Institut Gustave Roussy

Immunologie anti-tumorale et immunothérapie des cancers

Université Paris-Saclay

Institut Universitaire de France

Abstract

Intestinal microbiota have been proposed to induce commensal-specific memory T cells that cross-react with tumor-associated antigens. We identified major histocompatibility complex (MHC) class I-binding epitopes in the tail length tape measure protein (TMP) of a prophage found in the genome of the bacteriophage Enterococcus hirae Mice bearing E. hirae harboring this prophage mounted a TMP-specific H-2Kb-restricted CD8+ T lymphocyte response upon immunotherapy with cyclophosphamide or anti-PD-1 antibodies. Administration of bacterial strains engineered to express the TMP epitope improved immunotherapy in mice. In renal and lung cancer patients, the presence of the enterococcal prophage in stools and expression of a TMP-cross-reactive antigen by tumors correlated with long-term benefit of PD-1 blockade therapy. In melanoma patients, T cell clones recognizing naturally processed cancer antigens that are cross-reactive with microbial peptides were detected.

Domains

Life Sciences [q-bio] Cancer

Fichier principal

FluckigerEq3.pdf (4.08 Mo)

Origin : Files produced by the author(s)

Elizabeth Bernardo : Connect in order to contact the contributor

https://www.hal.inserm.fr/inserm-02923397

Submitted on : Thursday, August 27, 2020-9:41:46 AM

Last modification on : Tuesday, January 10, 2023-8:32:37 AM

Long-term archiving on: Saturday, November 28, 2020-12:10:43 PM

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inserm-02923397 , version 1 (27-08-2020)

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HAL Id : inserm-02923397 , version 1
DOI : 10.1126/science.aax0701
PUBMED : 32820119

Cite

Aurélie Fluckiger, Romain Daillere, Mohamed Sassi, Barbara S Sixt, Peng Liu, et al.. Cross-reactivity between tumor MHC class I-restricted antigens and an enterococcal bacteriophage. Science, 2020, 369 (6506), pp.936-942. ⟨10.1126/science.aax0701⟩. ⟨inserm-02923397⟩

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Cross-reactivity between tumor MHC class I-restricted antigens and an enterococcal bacteriophage

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