A. Alioua, R. Lu, Y. Kumar, M. Eghbali, P. Kundu et al., Slo1 caveolin-binding motif, a mechanism of caveolin-1-Slo1 interaction regulating Slo1 surface expression, The Journal of biological chemistry, vol.283, pp.4808-4825, 2008.

I. Azimi and G. R. Monteith, Plasma membrane ion channels and epithelial to mesenchymal transition in cancer cells, Endocr. Relat. Cancer, vol.23, pp.517-525, 2016.


M. Badaoui, C. Mimsy-julienne, C. Saby, L. Van-gulick, M. Peretti et al., Collagen type 1 promotes survival of human breast cancer cells by overexpressing Kv10.1 potassium and Orai1 calcium channels through DDR1-dependent pathway, Oncotarget, vol.9, pp.24653-24671, 2018.
URL : https://hal.archives-ouvertes.fr/hal-02310419


D. Balasuriya, L. D'sa, R. Talker, E. Dupuis, F. Maurin et al., A direct interaction between the sigma-1 receptor and the hERG voltage-gated K+ channel revealed by atomic force microscopy and homogeneous time-resolved fluorescence (HTRF®), J. Biol. Chem, vol.289, pp.32353-32363, 2014.

D. Balasuriya, A. P. Stewart, D. Crottès, F. Borgese, O. Soriani et al., The sigma-1 receptor binds to the Nav1.5 voltage-gated Na+ channel with 4-fold symmetry, J. Biol. Chem, vol.287, pp.37021-37029, 2012.
URL : https://hal.archives-ouvertes.fr/hal-00760249


A. Becchetti, G. Petroni, and A. Arcangeli, Ion Channel Conformations Regulate Integrin-Dependent Signaling, Trends Cell Biol, vol.29, pp.298-307, 2019.


A. H. Bong and G. R. Monteith, Calcium signaling and the therapeutic targeting of cancer cells, Biochimica et Biophysica Acta (BBA) -Molecular Cell Research, vol.1865, pp.1786-1794, 2018.

P. J. Buchanan and K. D. Mccloskey, CaV channels and cancer: canonical functions indicate benefits of repurposed drugs as cancer therapeutics, Eur Biophys J, vol.45, pp.621-633, 2016.

S. B. Chalmers and G. R. Monteith, ORAI channels and cancer. Cell Calcium, vol.74, pp.160-167, 2018.

A. Chantome, M. Potier-cartereau, L. Clarysse, G. Fromont, S. Marionneau-lambot et al., Pivotal role of the lipid Raft SK3-Orai1 complex in human cancer cell migration and bone metastases, Cancer research, vol.73, pp.4852-61, 2013.
URL : https://hal.archives-ouvertes.fr/inserm-00848873

H. Cheng, S. Wang, and R. Feng, STIM1 plays an important role in TGF-?-induced suppression of breast cancer cell proliferation, Oncotarget, vol.7, pp.16866-16878, 2016.


J. Cooper and F. G. Giancotti, Integrin Signaling in Cancer: Mechanotransduction, Stemness, Epithelial Plasticity, and Therapeutic Resistance, Cancer Cell, vol.35, pp.347-367, 2019.


J. H. Cox, S. Hussell, H. Søndergaard, K. Roepstorff, J. Bui et al., Antibody-mediated targeting of the Orai1 calcium channel inhibits T cell function, PLoS ONE, vol.8, 2013.

D. Crottès, H. Guizouarn, P. Martin, F. Borgese, and O. Soriani, The sigma-1 receptor: a regulator of cancer cell electrical plasticity?, Front Physiol, vol.4, 2013.

D. Crottès, S. Martial, R. Rapetti-mauss, D. F. Pisani, C. Loriol et al., Sig1R protein regulates hERG channel expression through a post-translational mechanism in leukemic cells, J. Biol. Chem, vol.286, pp.27947-27958, 2011.

D. Crottès, R. Rapetti-mauss, F. Alcaraz-perez, M. Tichet, G. Gariano et al., SIGMAR1 Regulates Membrane Electrical Activity in Response to Extracellular Matrix Stimulation to Drive Cancer Cell Invasiveness, Cancer Res, vol.76, pp.607-618, 2016.


F. M. Davis, I. Azimi, R. A. Faville, A. A. Peters, K. Jalink et al., Induction of epithelial-mesenchymal transition (EMT) in breast cancer cells is calcium signal dependent, Oncogene, vol.33, pp.2307-2316, 2014.

M. Debant, M. Burgos, P. Hemon, P. Buscaglia, T. Fali et al., STIM1 at the plasma membrane as a new target in progressive chronic lymphocytic leukemia, Journal for immunotherapy of cancer, vol.7, p.111, 2019.
URL : https://hal.archives-ouvertes.fr/hal-02114358

N. Déliot and B. Constantin, Plasma membrane calcium channels in cancer: Alterations and consequences for cell proliferation and migration, Biochim. Biophys. Acta, vol.1848, pp.2512-2522, 2015.

S. H. Den-uil, V. M. Coupé, J. F. Linnekamp, E. Van-den-broek, J. A. Goos et al., Loss of KCNQ1 expression in stage II and stage III colon cancer is a strong prognostic factor for disease recurrence, Br. J. Cancer, vol.115, pp.1565-1574, 2016.

X. W. Ding, H. S. Luo, X. Jin, J. J. Yan, and Y. W. Ai, Aberrant expression of Eag1 potassium channels in gastric cancer patients and cell lines, Medical oncology, vol.24, pp.345-50, 2007.

X. W. Ding, H. S. Luo, J. J. Yan, P. An, and P. Lu, , 2007.

, Zhonghua bing li xue za zhi = Chinese journal of pathology, vol.36, pp.410-411

X. W. Ding, X. G. Wang, H. S. Luo, S. Y. Tan, S. Gao et al., Expression and prognostic roles of Eag1 in resected esophageal squamous cell carcinomas, 2008.

, Digestive diseases and sciences, vol.53, pp.2039-2083

C. Dubois, F. Vanden-abeele, V. Lehen'kyi, D. Gkika, B. Guarmit et al., Remodeling of Channel-Forming ORAI Proteins Determines an Oncogenic Switch in Prostate Cancer, Cancer Cell, vol.26, pp.19-32, 2014.


F. Elinder and S. I. Liin, Actions and Mechanisms of Polyunsaturated Fatty Acids on Voltage-Gated Ion Channels, Frontiers in physiology, vol.8, p.43, 2017.

H. Fan, M. Zhang, and W. Liu, Hypermethylated KCNQ1 acts as a tumor suppressor in hepatocellular carcinoma, Biochem. Biophys. Res. Commun, vol.503, pp.3100-3107, 2018.


S. Figiel, F. Bery, A. Chantôme, D. Fontaine, C. Pasqualin et al., A Novel Calcium-Mediated EMT Pathway Controlled by Lipids: An Opportunity for Prostate Cancer Adjuvant Therapy, Cancers, p.11, 2019.
URL : https://hal.archives-ouvertes.fr/hal-02460772


A. Fiore, L. Carraresi, A. Morabito, S. Polvani, A. Fortunato et al., Characterization of hERG1 channel role in mouse colorectal carcinogenesis, Cancer Med, vol.2, pp.583-594, 2013.


K. Fukunaga, Y. Shinoda, and H. Tagashira, The role of SIGMAR1 gene mutation and mitochondrial dysfunction in amyotrophic lateral sclerosis, J. Pharmacol. Sci, vol.127, pp.36-41, 2015.

A. Gambade, S. Zreika, M. Gueguinou, I. Chourpa, G. Fromont et al., Activation of TRPV2 and BKCa channels by the LL-37 enantiomers stimulates calcium entry and migration of cancer cells, Oncotarget, vol.7, pp.23785-800, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01387061

S. Garaud, T. E. Taher, M. Debant, M. Burgos, S. Melayah et al., CD5 expression promotes IL-10 production through activation of the MAPK/Erk pathway and upregulation of TRPC1, 2018.
URL : https://hal.archives-ouvertes.fr/hal-01353347

V. Garg, W. Sun, and K. Hu, Caveolin-3 negatively regulates recombinant cardiac K(ATP) channels, Biochemical and biophysical research communications, vol.385, pp.472-479, 2009.

D. Gomez-varela, E. Zwick-wallasch, H. Knotgen, A. Sanchez, T. Hettmann et al., Monoclonal antibody blockade of the human Eag1 potassium channel function exerts antitumor activity, Cancer research, vol.67, pp.7343-7352, 2007.

M. Gueguinou, A. Chantome, G. Fromont, P. Bougnoux, C. Vandier et al., KCa and Ca(2+) channels: the complex thought, Biochimica et biophysica acta, vol.1843, pp.2322-2355, 2014.
URL : https://hal.archives-ouvertes.fr/hal-02372872

M. Gueguinou, D. Crottes, A. Chantome, R. Rapetti-mauss, M. Potier-cartereau et al., The SigmaR1 chaperone drives breast and colorectal cancer cell migration, 2017.
URL : https://hal.archives-ouvertes.fr/hal-02372859

, Oncogene, vol.36, pp.3640-3647

M. Gueguinou, A. Gambade, R. Felix, A. Chantome, Y. Fourbon et al., Lipid rafts, KCa/ClCa/Ca2+ channel complexes and EGFR signaling: Novel targets to reduce tumor development by lipids?, Biochimica et biophysica acta, vol.1848, pp.2603-2623, 2015.
URL : https://hal.archives-ouvertes.fr/hal-02372867

M. Gueguinou, T. Harnois, D. Crottes, A. Uguen, N. Deliot et al., , p.28

M. Cartereau, SK3/TRPC1/Orai1 complex regulates SOCE-dependent colon cancer cell migration: a novel opportunity to modulate anti-EGFR mAb action by the alkyl-lipid Ohmline, Oncotarget, vol.7, pp.36168-36184, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01539569

C. Habes, G. Weber, and C. Goupille, Sulfated Glycoaminoglycans and Proteoglycan Syndecan-4 Are Involved in Membrane Fixation of LL-37 and Its Pro-Migratory Effect in Breast Cancer Cells, 2019.

K. L. Hamilton, C. A. Syme, and D. C. Devor, Molecular localization of the inhibitory arachidonic acid binding site to the pore of hIK1, The Journal of biological chemistry, vol.278, pp.16690-16697, 2003.

F. Hartung, W. Stuhmer, and L. A. Pardo, Tumor cell-selective apoptosis induction through targeting of K(V)10.1 via bifunctional TRAIL antibody, Molecular cancer, vol.10, p.109, 2011.

A. Haustrate, A. Hantute-ghesquier, N. Prevarskaya, and V. Lehen'kyi, Monoclonal Antibodies Targeting Ion Channels and Their Therapeutic Potential, Frontiers in pharmacology, vol.10, p.606, 2019.

D. Heitzmann and R. Warth, Physiology and pathophysiology of potassium channels in gastrointestinal epithelia, Physiol. Rev, vol.88, pp.1119-1182, 2008.


F. E. Herrera, C. M. Sevrain, P. A. Jaffres, H. Couthon, A. Grelard et al., Singular Interaction between an Antimetastatic Agent and the Lipid Bilayer: The Ohmline Case, ACS omega, vol.2, pp.6361-6370, 2017.
URL : https://hal.archives-ouvertes.fr/hal-01624549

J. Hu, K. Qin, Y. Zhang, J. Gong, N. Li et al., Downregulation of transcription factor Oct4 induces an epithelial-to-mesenchymal transition via 29 enhancement of Ca2+ influx in breast cancer cells, Biochem. Biophys. Res. Commun, vol.411, pp.786-791, 2011.

C. J. Hutchings, P. Colussi, and T. G. Clark, Ion channels as therapeutic antibody targets, mAbs, vol.11, pp.265-296, 2019.

S. Ibrahim, H. Dakik, C. Vandier, R. Chautard, G. Paintaud et al., Expression Profiling of Calcium Channels and Calcium-Activated Potassium Channels in Colorectal Cancer, Cancers, vol.11
URL : https://hal.archives-ouvertes.fr/inserm-02152189

T. Jespersen, M. Grunnet, and S. Olesen, The KCNQ1 potassium channel: from gene to physiological function, Physiology (Bethesda), vol.20, pp.408-416, 2005.


A. M. Jimenez-garduno, M. Mitkovski, I. K. Alexopoulos, A. Sanchez, W. Stuhmer et al., KV10.1 K(+)-channel plasma membrane discrete domain partitioning and its functional correlation in neurons, Biochimica et biophysica acta, vol.1838, pp.921-952, 2014.

N. Joubert, C. Denevault-sabourin, F. Bryden, and M. C. Viaud-massuard, Towards antibody-drug conjugates and prodrug strategies with extracellular stimuli-responsive drug delivery in the tumor microenvironment for cancer therapy, European journal of medicinal chemistry, vol.142, pp.393-415, 2017.
URL : https://hal.archives-ouvertes.fr/hal-02389855

M. Kacik, A. Olivan-viguera, and R. Kohler, Modulation of K(Ca)3.1 channels by eicosanoids, omega-3 fatty acids, and molecular determinants, PloS one, vol.9, 2014.

S. Kappel, A. Borgström, P. Stok?osa, K. Dörr, and C. Peinelt, Store-operated calcium entry in disease: Beyond STIM/Orai expression levels, Seminars in Cell & Developmental Biology, vol.94, pp.66-73, 2019.

T. Kohl, E. Lorinczi, L. A. Pardo, and W. Stuhmer, Rapid internalization of the oncogenic K+ channel K(V)10.1. PloS one 6, 2011.

S. Kourrich, T. Hayashi, J. Chuang, S. Tsai, T. Su et al., Dynamic interaction between sigma-1 receptor and Kv1.2 shapes neuronal and behavioral responses to cocaine, Cell, vol.152, pp.236-247, 2013.

W. Lai, L. Liu, Y. Zeng, H. Wu, H. Xu et al., KCNN4 channels participate in the EMT induced by PRL-3 in colorectal cancer, Med. Oncol, vol.30, 2013.

F. Lin, R. Elliott, A. Colombero, K. Gaida, L. Kelley et al., Generation and Characterization of Fully Human Monoclonal Antibodies Against Human Orai1 for Autoimmune Disease, J Pharmacol Exp Ther, vol.345, pp.225-238, 2013.


P. A. Lopes, R. Martins, I. V. Da-silva, M. S. Madeira, J. A. Prates et al., Modulation of aquaporin gene expression by n-3 long-chain PUFA lipid structures in white and brown adipose tissue from hamsters, The British journal of nutrition, vol.120, pp.1098-1106, 2018.

J. A. Lundbaek, P. Birn, J. Girshman, A. J. Hansen, and O. S. Andersen, Membrane stiffness and channel function, Biochemistry, vol.35, pp.3825-3855, 1996.

F. Maingret, A. J. Patel, F. Lesage, M. Lazdunski, and E. Honore, Lysophospholipids open the two-pore domain mechano-gated K(+) channels TREK-1 and TRAAK, The Journal of biological chemistry, vol.275, pp.10128-10161, 2000.

S. S. Manji, N. J. Parker, R. T. Williams, L. Van-stekelenburg, R. B. Pearson et al., , 2000.

, Biochim. Biophys. Acta, vol.1481, issue.00, pp.105-114

M. J. Marques-carvalho, J. Oppermann, E. Munoz, A. S. Fernandes, G. Gabant et al., Molecular Insights into the Mechanism of Calmodulin Inhibition of the EAG1 Potassium Channel, Structure, vol.24, pp.1742-1754, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01407944

O. Mignen, B. Constantin, M. Potier-cartereau, A. Penna, M. Gautier et al., Constitutive calcium entry and cancer: updated views and insights, Eur Biophys J, vol.46, pp.395-413, 2017.
URL : https://hal.archives-ouvertes.fr/inserm-01526286

J. Napp, L. A. Pardo, F. Hartung, L. F. Tietze, W. Stuhmer et al., In vivo imaging of tumour xenografts with an antibody targeting the potassium channel Kv10.1, Eur Biophys J, vol.45, pp.721-733, 2016.

H. A. Nelson and M. W. Roe, Molecular physiology and pathophysiology of stromal interaction molecules, Exp Biol Med (Maywood), vol.243, pp.451-472, 2018.


L. A. Pardo and W. Stuhmer, Eag1: an emerging oncological target, Cancer research, vol.68, pp.1611-1614, 2008.

B. Penke, L. Fulop, M. Szucs, and E. Frecska, The Role of Sigma-1 Receptor, an Intracellular Chaperone in Neurodegenerative Diseases, Curr Neuropharmacol, vol.16, pp.97-116, 2018.

M. Peretti, M. Badaoui, A. Girault, L. Van-gulick, M. P. Mabille et al., Original association of ion transporters mediates the ECM-induced breast cancer cell survival: Kv10.1-Orai1-SPCA2 partnership, Scientific reports, vol.9, 2019.
URL : https://hal.archives-ouvertes.fr/hal-02310333

E. Piktel, K. Niemirowicz, U. Wnorowska, M. W?tek, T. Wollny et al., The Role of Cathelicidin LL-37 in Cancer Development, Arch. Immunol. Ther. Exp. (Warsz.), vol.64, pp.33-46, 2016.

S. Pillozzi, M. F. Brizzi, P. A. Bernabei, B. Bartolozzi, R. Caporale et al., VEGFR-1 (FLT-1), beta1 integrin, and hERG K+ channel for a macromolecular signaling complex in acute myeloid leukemia: role in cell migration and clinical outcome, Blood, vol.110, pp.1238-1250, 2007.


O. Pochynyuk, J. Medina, N. Gamper, H. Genth, J. D. Stockand et al., Rapid translocation and insertion of the epithelial Na+ channel in response to RhoA signaling, The Journal of biological chemistry, vol.281, pp.26520-26527, 2006.

R. Qiu and R. S. Lewis, Structural features of STIM and Orai underlying store-operated calcium entry, Current Opinion in Cell Biology, vol.57, pp.90-98, 2019.


R. Rapetti-mauss, V. Bustos, W. Thomas, J. Mcbryan, H. Harvey et al., Bidirectional KCNQ1:?-catenin interaction drives colorectal cancer cell differentiation, Proc. Natl, 2017.

, Acad. Sci. U.S.A, vol.114, pp.4159-4164

L. O. Romero, A. E. Massey, A. D. Mata-daboin, F. J. Sierra-valdez, S. C. Chauhan et al., Dietary fatty acids fine-tune Piezo1 mechanical response, Nature communications, vol.10, p.1200, 2019.

J. Säll, M. Carlsson, O. Gidlöf, A. Holm, J. Humlén et al., The antimicrobial peptide LL-37 alters human osteoblast Ca2+ handling and induces Ca2+-independent apoptosis, J Innate Immun, vol.5, pp.290-300, 2013.

A. Schaar, P. Sukumaran, Y. Sun, A. Dhasarathy, and B. B. Singh, TRPC1-STIM1 activation modulates transforming growth factor ?-induced epithelial-to-mesenchymal transition, Oncotarget, vol.7, pp.80554-80567, 2016.

L. V. Schagina, K. Blasko, A. E. Grinfeldt, Y. E. Korchev, and A. A. Lev, Cholesteroldependent gramicidin A channel inactivation in red blood cell membranes and lipid bilayer membranes, Biochimica et biophysica acta, vol.978, pp.145-50, 1989.

L. V. Schagina, Y. E. Korchev, A. E. Grinfeldt, A. A. Lev, and K. Blasto, Sterol specific inactivation of gramicidin A induced membrane cation permeability, Biochimica et biophysica acta, vol.1109, pp.91-97, 1992.

R. Schonherr, Inhibition of human ether a go-go potassium channels by Ca2+/calmodulin, The EMBO Journal, vol.19, pp.3263-3271, 2000.


S. Sharma, N. Sahoo, and A. Bhunia, Antimicrobial Peptides and their Pore/Ion Channel Properties in Neutralization of Pathogenic Microbes, Curr Top Med Chem, vol.16, pp.46-53, 2016.

T. J. Shuttleworth, J. L. Thompson, and O. Mignen, STIM1 and the noncapacitative ARC channels, Cell Calcium, vol.42, pp.183-191, 2007.

K. Simons and D. Toomre, Lipid rafts and signal transduction, Nature reviews, vol.1, pp.31-40, 2000.

D. K. Singh, A. Rosenhouse-dantsker, C. G. Nichols, D. Enkvetchakul, and I. Levitan, Direct regulation of prokaryotic Kir channel by cholesterol, The Journal of biological chemistry, vol.284, pp.30727-30763, 2009.

R. C. Soletti, L. Del-barrio, S. Daffre, A. Miranda, H. L. Borges et al., Peptide gomesin triggers cell death through L-type channel calcium influx, MAPK/ERK, PKC and PI3K signaling and generation of reactive oxygen species, Chem. Biol. Interact, vol.186, pp.135-143, 2010.


R. Sood, Y. Domanov, M. Pietiainen, V. P. Kontinen, and P. K. Kinnunen, Binding of LL-37 to model biomembranes: insight into target vs host cell recognition, Biochimica et biophysica acta, vol.1778, pp.983-96, 2008.

R. Sood and P. K. Kinnunen, Cholesterol, lanosterol, and ergosterol attenuate the membrane association of LL-37(W27F) and temporin L, Biochimica et biophysica acta, vol.1778, pp.1460-1466, 2008.

O. Soriani and R. Rapetti-mauss, Sigma 1 Receptor and Ion Channel Dynamics in Cancer, Adv. Exp. Med. Biol, vol.964, pp.63-77, 2017.

T. Su, T. Hayashi, T. Maurice, S. Buch, and A. E. Ruoho, The sigma-1 receptor chaperone as an inter-organelle signaling modulator, Trends Pharmacol. Sci, vol.31, pp.557-566, 2010.

B. L. Than, J. A. Goos, A. L. Sarver, M. G. O'sullivan, A. Rod et al., The role of KCNQ1 in mouse and human gastrointestinal cancers, Oncogene, vol.33, pp.3861-3868, 2014.

J. L. Thompson, O. Mignen, and T. J. Shuttleworth, The ARC Channel-An Endogenous Store-Independent Orai Channel, Current Topics in Membranes, pp.125-148, 2013.

Y. Tian, M. Aursnes, T. V. Hansen, J. E. Tungen, J. D. Galpin et al., Atomic determinants of BK channel activation by polyunsaturated fatty acids, Proceedings of the National Academy of Sciences of the United States of America, vol.113, pp.13905-13910, 2016.

S. Tsai, T. Hayashi, T. Mori, and T. Su, Sigma-1 receptor chaperones and diseases, Cent Nerv Syst Agents Med Chem, vol.9, pp.184-189, 2009.


M. Uhlen, L. Fagerberg, B. M. Hallstrom, C. Lindskog, P. Oksvold et al., Proteomics. Tissue-based map of the human proteome, Science, vol.347, p.1260419, 2015.
URL : https://hal.archives-ouvertes.fr/hal-02280776

E. T. Verjans, S. Zels, W. Luyten, B. Landuyt, and L. Schoofs, Molecular mechanisms of LL-37-induced receptor activation: An overview, Peptides, vol.85, pp.16-26, 2016.

G. Weber, C. I. Chamorro, F. Granath, A. Liljegren, S. Zreika et al., Human antimicrobial protein hCAP18/LL-37 promotes a metastatic phenotype in breast cancer, Breast Cancer Res, vol.11, 2009.
URL : https://hal.archives-ouvertes.fr/hal-00375670

R. T. Williams, P. V. Senior, L. Van-stekelenburg, J. E. Layton, P. J. Smith et al., Stromal interaction molecule 1 (STIM1), a transmembrane protein with growth suppressor activity, contains an extracellular SAM domain modified by N-linked glycosylation, Biochim. Biophys. Acta, vol.1596, issue.02, p.211, 2002.

K. Yamamoto and J. Ando, Vascular endothelial cell membranes differentiate between stretch and shear stress through transitions in their lipid phases, American journal of physiology, vol.309, pp.1178-85, 2015.

F. Zakany, P. Pap, F. Papp, T. Kovacs, P. Nagy et al., Determining the target of membrane sterols on voltage-gated potassium channels, Biochimica et biophysica acta. Molecular and cell biology of lipids, 2018.