Potassium and Calcium Channel Complexes as Novel Targets for Cancer Research - Archive ouverte HAL Access content directly
Journal Articles Reviews of Physiology Biochemistry and Pharmacology Year : 2020

Potassium and Calcium Channel Complexes as Novel Targets for Cancer Research

Complexes de canaux potassiques et calciques : nouvelles cibles pour la recherche sur le cancer

(1) , (1, 2) , (2, 1) , (1) , (3) , (4) , (5) , (6, 1) , (5) , (5) , (7, 4) , (8, 1) , (1) , (5) , (3) , (1)
1
2
3
4
5
6
7
8
Raphaël Rapetti-Mauss

Abstract

The intracellular Ca2+ concentration is mainly controlled by Ca2+ channels. These channels form complexes with K+ channels, which function to amplify Ca2+ flux. In cancer cells, voltage-gated/voltage-dependent Ca2+ channels and non-voltage-gated/voltage-independent Ca2+ channels have been reported to interact with K+ channels such as Ca2+-activated K+ channels and voltage-gated K+ channels. These channels are activated by an increase in cytosolic Ca2+ concentration or by membrane depolarization, which induces membrane hyperpolarization, increasing the driving force for Ca2+ flux. These complexes, composed of K+ and Ca2+ channels, are regulated by several molecules including lipids (ether lipids and cholesterol), proteins (e.g. STIM), receptors (e.g. S1R/SIGMAR1), and peptides (e.g. LL-37) and can be targeted by monoclonal antibodies, making them novel targets for cancer research.
Fichier principal
Vignette du fichier
PotierCartereau_Manuscript_RPBP-D-19-00034R1_accepted.pdf (258.01 Ko) Télécharger le fichier
Origin : Files produced by the author(s)
Loading...

Dates and versions

inserm-02921492 , version 1 (26-08-2020)

Identifiers

Cite

Marie Potier-Cartereau, William Raoul, Günther Weber, Karine Mahéo, Raphaël Rapetti-Mauss, et al.. Potassium and Calcium Channel Complexes as Novel Targets for Cancer Research. Reviews of Physiology Biochemistry and Pharmacology, 2020, Epub 2020 - 08 August. ⟨10.1007/112_2020_24⟩. ⟨inserm-02921492⟩
99 View
155 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More