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Potassium and Calcium Channel Complexes as Novel Targets for Cancer Research

Abstract : The intracellular Ca2+ concentration is mainly controlled by Ca2+ channels. These channels form complexes with K+ channels, which function to amplify Ca2+ flux. In cancer cells, voltage-gated/voltage-dependent Ca2+ channels and non-voltage-gated/voltage-independent Ca2+ channels have been reported to interact with K+ channels such as Ca2+-activated K+ channels and voltage-gated K+ channels. These channels are activated by an increase in cytosolic Ca2+ concentration or by membrane depolarization, which induces membrane hyperpolarization, increasing the driving force for Ca2+ flux. These complexes, composed of K+ and Ca2+ channels, are regulated by several molecules including lipids (ether lipids and cholesterol), proteins (e.g. STIM), receptors (e.g. S1R/SIGMAR1), and peptides (e.g. LL-37) and can be targeted by monoclonal antibodies, making them novel targets for cancer research.
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Submitted on : Wednesday, August 26, 2020 - 9:55:47 AM
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Marie Potier-Cartereau, William Raoul, Günther Weber, Karine Mahéo, Raphaël Rapetti-Mauss, et al.. Potassium and Calcium Channel Complexes as Novel Targets for Cancer Research. Reviews of Physiology Biochemistry and Pharmacology, Springer Verlag, 2020, Epub 2020 - 08 August. ⟨10.1007/112_2020_24⟩. ⟨inserm-02921492⟩



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