J. A. Whitsett, T. V. Kalin, Y. Xu, and V. V. Kalinichenko, Building and Regenerating the Lung 645 Cell by Cell, Physiological reviews, vol.2019, issue.1, pp.513-554

E. E. Morrisey and B. L. Hogan, Preparing for the first breath: genetic and cellular 647 mechanisms in lung development, Developmental cell, vol.2010, issue.1, pp.8-23

. Euro-peristat-project, European Perinatal Health Report. Core indicators of the 649 health and care of pregnant women and babies in Europe in 2015

L. Liu, S. Oza, D. Hogan, and J. Perin,

, Global, regional, and national causes of child mortality in 2000-13, with projections to inform 653 post-2015 priorities: an updated systematic analysis, Lancet, vol.2015, issue.9966, pp.430-440

A. J. Jobe, The new BPD: an arrest of lung development, Pediatric research, issue.6, pp.641-643, 1999.

E. Baraldi and M. Filippone, Chronic lung disease after premature birth. The New England 657 journal of medicine, pp.1946-1955, 2007.

J. E. Maclean, K. Dehaan, D. Fuhr, S. Hariharan, B. Kamstra et al., , p.659

C. Majaesic, A. T. Lovering, R. B. Thompson, D. Nicholas, B. Thebaud et al., Altered 660 breathing mechanics and ventilatory response during exercise in children born extremely 661 preterm, Thorax, vol.2016, issue.11, pp.1012-1019

M. K. Tracy and S. K. Berkelhamer, Bronchopulmonary Dysplasia and Pulmonary Outcomes 663 of Prematurity, Pediatric annals, vol.2019, issue.4, pp.148-153

A. Hadchouel, J. Rousseau, J. C. Roze, C. Arnaud, A. Bellino et al., , p.665

M. Mittaine, D. Pinquier, M. Verstraete, P. Y. Ancel, C. Delacourt et al., Association between 666 asthma and lung function in adolescents born very preterm: results of the EPIPAGE cohort 667 study, Thorax, vol.2018, issue.12, pp.1174-1176

R. Urs, S. Kotecha, G. L. Hall, and S. J. Simpson, Persistent and progressive long-term lung 669 disease in survivors of preterm birth, Paediatric respiratory reviews, vol.28, pp.87-94, 2018.

E. Priante, L. Moschino, V. Mardegan, P. Manzoni, S. Salvadori et al.,

, Outcome after Preterm Birth: A Long and Difficult Journey, vol.672, pp.1040-1042, 2016.

V. Kumar, H. Wang, S. Kishkurno, B. S. Paturi, L. Nielsen et al., , p.674

, Effects of Neonatal Hyperoxia in Adult Mice, Anatomical, vol.301, issue.4, p.13, 2018.

R. T. Menon, A. K. Shrestha, C. L. Reynolds, R. Barrios, and B. Shivanna, Long-term pulmonary 676 and cardiovascular morbidities of neonatal hyperoxia exposure in mice. The international 677 journal of biochemistry, & cell biology, vol.94, pp.119-124, 2018.

F. Namba, R. Ogawa, M. Ito, T. Watanabe, P. A. Dennery et al., Sex-related 679 differences in long-term pulmonary outcomes of neonatal hyperoxia in mice, Experimental, vol.680, issue.2016, pp.57-65

A. M. Dylag, J. Haak, M. Yee, O. Ma-;-regal, J. F. Lawrence et al., Neonatal oxygen 684 exposure alters airway hyper-responsiveness but not the response to allergen challenge in 685 adult mice. Pediatric allergy and immunology, Pediatric research, vol.2020, issue.7, p.686

, Pediatric Allergy and Immunology, vol.2014, issue.2, pp.180-186

M. Yee, B. W. Buczynski, B. P. Lawrence, and O. Ma, Neonatal hyperoxia increases 688 sensitivity of adult mice to bleomycin-induced lung fibrosis. American journal of respiratory 689 cell and molecular biology, vol.48, pp.258-266, 2013.

S. G. Kallapur, P. Presicce, C. M. Rueda, A. H. Jobe, and C. A. Chougnet, Fetal immune 691 response to chorioamnionitis, Seminars in reproductive medicine, vol.2014, issue.1, p.19

S. G. Kallapur, K. E. Willet, A. H. Jobe, M. Ikegami, and C. J. Bachurski, Intra-amniotic endotoxin: 693 chorioamnionitis precedes lung maturation in preterm lambs. American journal of physiology 694 Lung cellular and molecular physiology, vol.280, pp.527-536, 2001.

K. E. Willet, A. H. Jobe, M. Ikegami, J. Newnham, S. Brennan et al., Antenatal endotoxin 696 and glucocorticoid effects on lung morphometry in preterm lambs, Pediatric research, issue.6, pp.782-788, 2000.

J. J. Collins, E. Kuypers, I. Nitsos, J. Pillow, J. Polglase et al., LPS-induced 700 chorioamnionitis and antenatal corticosteroids modulate Shh signaling in the ovine fetal lung

, American journal of physiology Lung cellular and molecular physiology, vol.2012, issue.9, pp.778-702

J. J. Collins, S. G. Kallapur, C. L. Knox, I. Nitsos, G. R. Polglase et al.,

J. P. Newnham, A. H. Jobe, and B. W. Kramer, Inflammation in fetal sheep from intra-amniotic 705 injection of Ureaplasma parvum. American journal of physiology Lung cellular and molecular 706 physiology, pp.852-860, 2010.

T. S. Blackwell, A. N. Hipps, Y. Yamamoto, W. Han, W. J. Barham et al., , p.708

L. S. Prince, NF-kappaB signaling in fetal lung macrophages disrupts airway morphogenesis, Journal of immunology, vol.709, issue.5, pp.2740-2747

S. G. Kallapur, T. J. Moss, M. Ikegami, R. L. Jasman, J. P. Newnham et al., Recruited 711 inflammatory cells mediate endotoxin-induced lung maturation in preterm fetal lambs

, American journal of respiratory and critical care medicine, vol.713, issue.10, p.25, 2005.

S. G. Kallapur, I. Nitsos, T. J. Moss, G. R. Polglase, J. J. Pillow et al., , p.714

J. P. Newnham, M. Ikegami, and A. H. Jobe, IL-1 mediates pulmonary and systemic inflammatory 715 responses to chorioamnionitis induced by lipopolysaccharide. American journal of respiratory 716 and critical care medicine, pp.955-961, 2009.

J. Collins, D. Tibboel, I. M. De-kleer, I. Reiss, and R. J. Rottier, The Future of 718

B. Dysplasia, Emerging Pathophysiological Concepts and Potential New 719 Avenues of Treatment, Frontiers in medicine, vol.2017, p.27

J. J. Collins, S. Kunzmann, E. Kuypers, M. W. Kemp, C. P. Speer et al., Antenatal glucocorticoids counteract LPS changes in TGF-beta 722 pathway and caveolin-1 in ovine fetal lung. American journal of physiology Lung cellular and 723 molecular physiology, Annual review of 725 immunology, vol.724, issue.6, pp.387-411, 2013.

P. C. Arck and K. Hecher, Fetomaternal immune cross-talk and its consequences for 727 maternal and offspring's health, Nature medicine, issue.5, pp.548-556, 2013.

D. J. Barker and K. L. Thornburg, The obstetric origins of health for a lifetime, Clinical 729 obstetrics and gynecology, vol.2013, issue.3, pp.511-519

H. Renz, P. Brandtzaeg, and M. Hornef, The impact of perinatal immune development on 731 mucosal homeostasis and chronic inflammation, Nature reviews Immunology, vol.12, issue.1, p.9, 2011.

A. C. Apostol, K. Jensen, and A. E. Beaudin, Training the Fetal Immune System Through 734 Maternal Inflammation-A Layered Hygiene Hypothesis, Frontiers in immunology, vol.2020, p.11

E. S. Gollwitzer, B. J. Marsland, A. N. Thorburn, C. I. Mckenzie, S. Shen et al., Impact of Early-Life Exposures on Immune Maturation 737 and Susceptibility to Disease, Trends in immunology, vol.2015, issue.11, p.739

C. H. Wong, R. Shim, R. Robert, C. N. Tan, J. K. Marino et al., , p.740

M. J. Mcconville, D. L. Tull, L. G. Wood, V. E. Murphy, J. Mattes et al., Evidence 741 that asthma is a developmental origin disease influenced by maternal diet and bacterial 742 metabolites, Nature communications, vol.2017, issue.5, pp.529-540, 2015.

V. E. Murphy, V. L. Clifton, and P. G. Gibson, Asthma exacerbations during pregnancy: 747 incidence and association with adverse pregnancy outcomes, Thorax, vol.748, issue.2, p.37, 2006.

X. Liu, E. Agerbo, V. Schlunssen, R. J. Wright, J. Li et al., Maternal asthma 749 severity and control during pregnancy and risk of offspring asthma, The Journal of allergy 750 and clinical immunology, vol.2018, issue.3, p.752

T. J. Doyle, M. Crockett, R. Lynfield, Z. Moore, C. Wiedeman et al., , p.753

K. Waller, S. Page, J. M. Thompson, C. Avery, C. B. Springs et al., , vol.754, p.29

L. Finelli, D. J. Jamieson, and P. Hniipwg, Pandemic 2009 influenza A(H1N1) virus illness 755 among pregnant women in the United States, Jama, vol.2010, issue.15, pp.1517-1525

C. Ober, A. I. Sperling, E. Von-mutius, and D. Vercelli, Immune development and 757 environment: lessons from Amish and Hutterite children, Current opinion in immunology, vol.758, pp.51-60, 2017.

E. Von-mutius and D. Vercelli, Farm living: effects on childhood asthma and allergy. 760, Nature reviews Immunology, vol.2010, issue.12, pp.861-868

M. J. Ege, M. Mayer, A. C. Normand, J. Genuneit, W. O. Cookson et al., , p.762

D. Heederik, R. Piarroux, E. Von-mutius, and G. Group, Exposure to environmental 763 microorganisms and childhood asthma, The New England journal of medicine, vol.2011, issue.8

G. Loss, S. Bitter, J. Wohlgensinger, R. Frei, C. Roduit et al., , p.766

M. Roponen, M. R. Hirvonen, J. C. Dalphin, M. L. Dalphin, J. Riedler et al., , p.767

M. Kabesch, S. Michel, C. Braun-fahrlander, R. Lauener, and P. Group, Prenatal and early-life 768 exposures alter expression of innate immunity genes: the PASTURE cohort study. The 769, Journal of allergy and clinical immunology, vol.2012, issue.2, p.43

B. Schaub, J. Liu, S. Hoppler, I. Schleich, J. Huehn et al., , p.771

E. Mutius, Maternal farm exposure modulates neonatal immune mechanisms through 772 regulatory T cells, The Journal of allergy and clinical immunology, vol.123, issue.4, pp.774-782, 2009.

M. L. Conrad, R. Ferstl, R. Teich, S. Brand, N. Blumer et al., , p.775

A. Hanuszkiewicz, S. Akira, H. Wagner, O. Holst, E. Von-mutius et al., , p.776

H. Garn and H. Renz, Maternal TLR signaling is required for prenatal asthma protection by the 777 nonpathogenic microbe Acinetobacter lwoffii F78, The Journal of experimental medicine, vol.778, issue.13, pp.2869-2877, 2009.

M. J. Schuijs, M. A. Willart, K. Vergote, D. Gras, K. Deswarte et al., , p.780

R. Beyaert, G. Van-loo, F. Bracher, E. Von-mutius, P. Chanez et al.,

, Farm dust and endotoxin protect against allergy through A20 induction in lung epithelial 782 cells, Science, vol.2015, issue.6252, pp.1106-1110

K. T. Mincham, N. M. Scott, J. F. Lauzon-joset, J. Leffler, A. N. Larcombe et al., , p.784

S. A. Robertson, C. Pasquali, P. G. Holt, D. H. Strickland, M. G. Netea et al., Transplacental immune modulation with 785 a bacterial-derived agent protects against allergic airway inflammation, The Journal of 786 clinical, vol.128, issue.11, p.788, 2018.

R. J. Xavier, Trained immunity: A program of innate immune memory in health and disease, Science, vol.789, issue.6284, p.1098

I. Mitroulis, K. Ruppova, B. Wang, L. S. Chen, M. Grzybek et al., , p.791

M. Troullinaki, A. Palladini, I. Kourtzelis, A. Chatzigeorgiou, A. Schlitzer et al., , p.792

B. Isermann, M. Lesche, A. Petzold, K. Simons, I. Henry et al., , vol.793

N. Zamboni, P. Mirtschink, U. Coskun, G. Hajishengallis, M. G. Netea et al., , p.794

, Myelopoiesis Progenitors Is an Integral Component of Trained Immunity, Cell, vol.2018, issue.2, pp.147-161

N. M. Scott, J. F. Lauzon-joset, A. C. Jones, K. T. Mincham, N. M. Troy et al., , p.797

S. L. Prescott, S. A. Robertson, C. Pasquali, A. Bosco, P. G. Holt et al., Protection against 798 maternal infection-associated fetal growth restriction: proof-of-concept with a microbial-799 derived immunomodulator, Mucosal immunology, vol.2017, issue.3, pp.789-801

C. Pattaroni, M. L. Watzenboeck, S. Schneidegger, S. Kieser, N. C. Wong et al., , p.801

J. Pernot, L. Mercier, S. Knapp, L. P. Nicod, C. P. Marsland et al.,

, Life Formation of the Microbial and Immunological Environment of the Human Airways, Cell 803 host & microbe, vol.2018, issue.6, pp.857-865

W. H. Man, W. A. De-steenhuijsen-piters, D. Bogaert, A. Bosch, W. De-steenhuijsen-piters et al., The microbiota of the respiratory 805 tract: gatekeeper to respiratory health, Nature reviews Microbiology, vol.2017, issue.5, p.807

P. Pernet, P. De-groot, M. Eijkemans, B. Keijser, E. Sanders et al.,

, Maturation of the Infant Respiratory Microbiota, Environmental Drivers, and Health, vol.809, p.31

. Consequences, A Prospective Cohort Study. American journal of respiratory and critical care 810 medicine, pp.1582-1590, 2017.

W. H. Man, M. Clerc, W. De-steenhuijsen-piters, M. A. Van-houten, M. Chu et al., , p.812

B. Keijser, E. Sanders, and D. Bogaert, Loss of Microbial Topography between Oral and 813

, Nasopharyngeal Microbiota and Development of Respiratory Infections Early in Life

, American journal of respiratory and critical care medicine, vol.2019, issue.6, p.54

W. De-steenhuijsen-piters, S. P. Jochems, E. Mitsi, J. Rylance, S. Pojar et al., , p.816

E. L. German, M. Holloway, B. F. Carniel, M. Chu, K. Arp et al.,

W. H. Man, M. A. Van-houten, M. E. Merelle, A. M. Vlieger, M. Chu et al., Interaction between the nasal microbiota and S. pneumoniae in the context of live-818 attenuated influenza vaccine, Nature communications, vol.2019, issue.1, p.2981

. Eam and D. Bogaert, Bacterial and viral respiratory tract microbiota and host characteristics in 821 children with lower respiratory tract infections: a matched case-control study. The Lancet 822 Respiratory medicine, vol.7, pp.417-426, 2019.

S. Broughton, A. Roberts, G. Fox, E. Pollina, M. Zuckerman et al.,

, Prospective study of healthcare utilisation and respiratory morbidity due to RSV infection in 825 prematurely born infants, Thorax, issue.12, pp.1039-1044, 2005.

I. Olabarrieta, E. Gonzalez-carrasco, C. Calvo, F. Pozo, I. Casas et al.,

M. Van-tuyl, J. Liu, J. Wang, M. Kuliszewski, D. Tibboel et al., Hospital admission due to respiratory viral infections in moderate preterm, late preterm and 828 term infants during their first year of life, Allergol Immunopathol (Madr), vol.2015, issue.5, pp.469-473

, American journal of physiology Lung cellular and molecular physiology, vol.288, issue.1, pp.167-832, 2005.

M. A. Schwarz, F. Zhang, S. Gebb, V. Starnes, and D. Warburton, Endothelial monocyte 834 activating polypeptide II inhibits lung neovascularization and airway epithelial 835 morphogenesis, Mechanisms of development, pp.123-132, 2000.

M. A. Schwarz, L. Caldwell, D. Cafasso, and H. Zheng, Emerging pulmonary vasculature 837 lacks fate specification. American journal of physiology Lung cellular and molecular 838 physiology, vol.296, pp.71-81, 2009.

A. Lazarus, P. M. Del-moral, O. Ilovich, E. Mishani, D. Warburton et al., A perfusion-840 independent role of blood vessels in determining branching stereotypy of lung airways, Development, vol.841, issue.11, pp.2359-2368, 2011.

M. C. Parera, M. Van-dooren, M. Van-kempen, R. De-krijger, F. Grosveld et al., , p.843

R. Rottier, American 844 journal of physiology Lung cellular and molecular physiology, vol.288, p.63, 2005.

A. Armulik, G. Genove, and C. Betsholtz, Pericytes: developmental, physiological, and 846 pathological perspectives, problems, and promises, Developmental cell, vol.21, issue.2, p.193, 2011.

M. Sweeney and G. Foldes, It Takes Two: Endothelial-Perivascular Cell Cross-Talk in 849

A. Q. Sheikh, A. Misra, I. O. Rosas, R. H. Adams, and D. M. Greif, Smooth muscle cell 851 progenitors are primed to muscularize in pulmonary hypertension, Frontiers in cardiovascular medicine, vol.5, issue.7, pp.308-159, 2015.

I. Sluiter, I. Van-der-horst, P. Van-der-voorn, and A. Boerema-de-munck,

M. Kempen, R. De-krijger, D. Tibboel, I. Reiss, and R. J. Rottier, Premature differentiation of vascular 855 smooth muscle cells in human congenital diaphragmatic hernia. Experimental and molecular 856 pathology, vol.94, pp.195-202, 2013.

H. M. Kool, P. E. Burgisser, G. G. Edel, and I. De-kleer, , vol.858

I. , C. C. Van-cappellen, W. A. Kremers, G. J. Tibboel, D. Rottier et al., Inhibition of retinoic acid 859 signaling induces aberrant pericyte coverage and differentiation resulting in vascular defects 860 in congenital diaphragmatic hernia. American journal of physiology Lung cellular and 861 molecular physiology, pp.317-331, 2019.

N. Ricard, L. Tu, L. Hiress, M. Huertas, A. Phan et al., , p.863

A. Seferian, D. Montani, P. Dorfmuller, M. Humbert, and C. Guignabert, Increased pericyte coverage 864 33 mediated by endothelial-derived fibroblast growth factor-2 and interleukin-6 is a source of 865 smooth muscle-like cells in pulmonary hypertension, Circulation, vol.2014, issue.15, p.69

F. Chen, T. J. Desai, J. Qian, K. Niederreither, J. Lu et al., Inhibition of Tgf beta 867 signaling by endogenous retinoic acid is essential for primary lung bud induction. 868 Development, pp.2969-2979, 2007.

J. Bordenave, L. Tu, N. Berrebeh, R. Thuillet, A. Cumont et al., , vol.870

L. Savale, M. Humbert, A. Huertas, and C. Guignabert, Lineage Tracing Reveals the Dynamic 871 Contribution of Pericytes to the Blood Vessel Remodeling in Pulmonary Hypertension

T. Arteriosclerosis, , vol.40, pp.766-782, 2020.

J. J. Collins and B. Thebaud, Lung mesenchymal stromal cells in development and 874 disease: to serve and protect?, Antioxidants & redox signaling, vol.2014, issue.13, p.72

A. K. Perl and E. Gale, FGF signaling is required for myofibroblast differentiation during 876 alveolar regeneration. American journal of physiology Lung cellular and molecular 877 physiology, vol.297, pp.299-308, 2009.

T. S. Stappenbeck and H. Miyoshi, The role of stromal stem cells in tissue regeneration and 879 wound repair, Science, issue.5935, pp.1666-1669, 2009.

M. Han, X. Yang, G. Taylor, C. A. Burdsal, R. A. Anderson et al., Limb regeneration 881 in higher vertebrates: developing a roadmap, Anatomical record Part B, vol.882, issue.1, pp.14-24, 2005.

A. I. Caplan, T. Van-haaften, R. Byrne, S. Bonnet, G. Y. Rochefort et al., Journal of orthopaedic research : official 884 publication of the, Orthopaedic Research Society, vol.1991, issue.5, p.886

G. J. Parra, J. Galipeau, A. Haromy, F. Eaton, M. Chen et al., , p.887

S. L. Archer and B. Thebaud, Airway delivery of mesenchymal stem cells prevents arrested 888 alveolar growth in neonatal lung injury in rats. American journal of respiratory and critical 889 care medicine, pp.1131-1142, 2009.

M. Pierro, L. Ionescu, T. Montemurro, A. Vadivel, G. Weissmann et al., , p.891

S. Bodiga, F. Eaton, B. Peault, F. Mosca, L. Lazzari et al., Short-term, long-term and 892 34 paracrine effect of human umbilical cord-derived stem cells in lung injury prevention and 893 repair in experimental bronchopulmonary dysplasia, Thorax, vol.2013, issue.5, p.78

S. Augustine, M. T. Avey, B. Harrison, T. Locke, M. Ghannad et al.,

P. D. Bozyk, J. K. Bentley, M. J. Linn, A. M. Goldsmith, and R. E. Schumacher, Mesenchymal Stromal Cell Therapy in Bronchopulmonary Dysplasia: Systematic Review 896 and Meta-Analysis of Preclinical Studies, Stem cells translational medicine, vol.2017, issue.6, pp.897-2079

G. M. Filbrun, A. G. Hershenson, and M. B. , Isolation of tracheal aspirate mesenchymal stromal cells 900 predicts bronchopulmonary dysplasia, Pediatrics, vol.2010, issue.5, pp.1127-1133

A. P. Popova, J. K. Bentley, T. X. Cui, M. N. Richardson, M. J. Linn et al., Reduced platelet-derived growth factor receptor 903 expression is a primary feature of human bronchopulmonary dysplasia. American journal of 904 physiology Lung cellular and molecular physiology, vol.307, pp.231-239, 2014.

J. Collins, M. A. Lithopoulos, D. Santos, C. C. Issa, N. Mobius et al., , p.906

A. Vadivel and B. Thebaud, Impaired Angiogenic Supportive Capacity and Altered Gene 907

, Expression Profile of Resident CD146(+) Mesenchymal Stromal Cells Isolated from 908

, Hyperoxia-Injured Neonatal Rat Lungs. Stem cells and development, vol.2018, issue.16, pp.1109-909

M. A. Mobius, D. Freund, A. Vadivel, S. Koss, S. Mcconaghy et al., , p.911

B. Thebaud, Oxygen Disrupts Human Fetal Lung Mesenchymal Cells. Implications for, p.912

B. Dysplasia, American journal of respiratory cell and molecular biology, vol.913, issue.5, pp.592-600, 2019.

M. A. Mobius, M. Rudiger, J. A. Zepp, W. J. Zacharias, D. B. Frank et al., Morrisey 917 EE. Distinct Mesenchymal Lineages and Niches Promote Epithelial Self-Renewal and 918 Myofibrogenesis in the Lung, Molecular and cellular pediatrics, vol.2016, issue.1, pp.1134-1148

T. Peng, Y. Tian, C. J. Boogerd, M. M. Lu, R. S. Kadzik et al.,

. Ee, Coordination of heart and lung co-development by a multipotent cardiopulmonary 921 progenitor, Nature, vol.2013, issue.7464, pp.589-592

K. J. Travaglini, A. N. Nabhan, L. Penland, R. Sinha, A. Gillich et al., , p.924

S. R. Quake and M. A. Krasnow, A molecular cell atlas of the human lung from single cell RNA 925 sequencing, vol.2020, p.742320

M. Guo, Y. Du, J. J. Gokey, S. Ray, S. M. Bell et al., , p.927

S. S. Potter, J. A. Whitsett, and Y. Xu, Single cell RNA analysis identifies cellular heterogeneity and 928 adaptive responses of the lung at birth, Nature communications, vol.2019, issue.1, pp.37-929

T. Xie, Y. Wang, N. Deng, G. Huang, F. Taghavifar et al., , p.930

P. Chen, Z. Liu, B. Stripp, J. Tang, J. Liang et al., Single-Cell Deconvolution of 931

, Fibroblast Heterogeneity in Mouse Pulmonary Fibrosis. Cell reports, vol.2018, issue.13, p.3625

A. Ntokou, F. Klein, D. Dontireddy, S. Becker, S. Bellusci et al., , p.934

T. Braun, R. E. Morty, W. Seeger, R. Voswinckel, and K. Ahlbrecht, Characterization of the platelet-935 derived growth factor receptor-alpha-positive cell lineage during murine late lung 936 development, American journal of physiology Lung cellular and molecular physiology, issue.9, pp.942-958, 2015.

E. El-agha, A. Moiseenko, V. Kheirollahi, S. De-langhe, S. Crnkovic et al., , p.939

M. Szibor, D. Kosanovic, F. Schwind, R. T. Schermuly, I. Henneke et al., , p.940

S. Herold, A. Ntokou, K. Ahlbrecht, T. Braun, R. E. Morty et al., , p.941

, Way Conversion between Lipogenic and Myogenic Fibroblastic Phenotypes Marks the 942

S. Y. Tan and M. A. Krasnow, Developmental origin of lung macrophage diversity, Cell stem cell, vol.2017, issue.2, pp.1318-1327

C. P. Speer, Inflammation and bronchopulmonary dysplasia, Seminars in neonatology : 946 SN, vol.8, pp.29-38, 2003.

L. C. Eldredge, P. M. Treuting, A. M. Manicone, S. F. Ziegler, W. C. Parks et al.,

, CD11b(+) Mononuclear Cells Mitigate Hyperoxia-Induced Lung Injury in Neonatal Mice

, American journal of respiratory cell and molecular biology, vol.2016, issue.2, p.94

L. C. Eldredge, R. S. Creasy, S. Tanaka, J. F. Lai, and S. F. Ziegler, Imbalance of Ly-6C(hi), p.951

T. V. Ly-6c-;-kalymbetova, B. Selvakumar, J. A. Rodriguez-castillo, M. Gunjak, and C. Malainou, Monocytes/Macrophages Worsens Hyperoxia-Induced Lung Injury and Is Rescued 952 by IFN-gamma, Journal of immunology, vol.2019, issue.9, p.954

M. R. Heindl, A. Moiseenko, C. M. Chao, I. Vadasz, K. Mayer et al., , p.955

E. Friebertshauser, W. Seeger, S. Herold, and R. E. Morty, Resident alveolar macrophages are 956 master regulators of arrested alveolarization in experimental bronchopulmonary dysplasia

, The Journal of pathology, vol.2018, issue.2, pp.153-159

B. W. Buczynski, M. Yee, K. C. Martin, B. P. Lawrence, and O. Ma, Neonatal hyperoxia 959 alters the host response to influenza A virus infection in adult mice through multiple 960 pathways, American journal of physiology Lung cellular and molecular physiology, issue.4, pp.282-290, 2013.

E. C. Reilly, K. C. Martin, G. B. Jin, M. Yee, M. A. O'reilly et al., Neonatal hyperoxia 963 leads to persistent alterations in NK responses to influenza A virus infection, vol.308, p.98, 2015.

M. A. O'reilly, Y. M. Buczynski, B. W. Vitiello, P. F. Keng, P. C. Welle et al., , p.966

D. A. Dean and B. P. Lawrence, Neonatal oxygen increases sensitivity to influenza A virus infection 967 in adult mice by suppressing epithelial expression of Ear1. The American journal of 968 pathology, vol.181, pp.441-451, 2012.

E. Lignelli, F. Palumbo, D. Myti, and R. E. Morty, Recent advances in our understanding of 970 the mechanisms of lung alveolarization and bronchopulmonary dysplasia, American journal 971 of physiology Lung cellular and molecular physiology, vol.2019, issue.6, pp.832-887

F. Ginhoux, Fate PPAR-titioning: PPAR-gamma 'instructs' alveolar macrophage 973 development, Nature immunology, vol.2014, issue.11, pp.1005-1007

M. Kopf, C. Schneider, and S. P. Nobs, The development and function of lung-resident 975 macrophages and dendritic cells, Nature immunology, vol.2015, issue.1, pp.36-44

M. Guilliams, D. Kleer, I. , H. S. Post, S. Vanhoutte et al., , p.977

B. Malissen, H. Hammad, and B. N. Lambrecht, Alveolar macrophages develop from fetal 978 monocytes that differentiate into long-lived cells in the first week of life via GM-CSF, The 979 Journal of experimental medicine, vol.2013, issue.10, pp.1977-1992

S. Saluzzo, A. D. Gorki, B. Rana, R. Martins, S. Scanlon et al.,

, Breath-Induced Type 2 Pathways Shape the Lung Immune Environment, Cell reports, issue.8, pp.1893-1905, 2017.

I. M. De-kleer, M. Kool, M. J. De-bruijn, M. Willart, J. Van-moorleghem et al., , p.985

M. Plantinga, R. Beyaert, E. Hams, P. G. Fallon, H. Hammad et al.,

, Perinatal Activation of the Interleukin-33 Pathway Promotes Type 2 Immunity in the 987 Developing Lung, Immunity, vol.2016, issue.6, pp.1285-1298

M. Cohen, A. Giladi, A. D. Gorki, D. G. Solodkin, M. Zada et al., , p.989

K. B. Halpern, E. David, S. Itzkovitz, T. Harkany, S. Knapp et al., Lung Single-Cell Signaling, vol.990

, Interaction Map Reveals Basophil Role in Macrophage Imprinting, Cell, vol.2018, issue.4, pp.1031-991, 10441018.

K. Oherle, E. Acker, M. Bonfield, T. Wang, J. Gray et al., , p.993

Y. , A. S. Zacharias, W. Alenghat, T. Deshmukh, and H. , Insulin-like Growth Factor 1 Supports a 994

, Pulmonary Niche that Promotes Type 3 Innate Lymphoid Cell Development in Newborn 995 Lungs, Immunity, vol.2020, issue.4, pp.716-718

S. Brugman, O. Perdijk, R. J. Van-neerven, and H. F. Savelkoul, Mucosal Immune, p.997

, Development in Early Life: Setting the Stage. Archivum immunologiae et therapiae 998 experimentalis 2015, vol.63, pp.251-268

M. Marzi, A. Vigano, D. Trabattoni, M. L. Villa, A. Salvaggio et al., 1000 Characterization of type 1 and type 2 cytokine production profile in physiologic and 1001 pathologic human pregnancy, Clinical and experimental immunology, vol.1996, issue.1, pp.127-133

S. L. Prescott, C. Macaubes, A. Yabuhara, T. J. Venaille, B. J. Holt et al.,

. Pd and P. G. Holt, Developing patterns of T cell memory to environmental allergens in the first two 1004 years of life, International archives of allergy and immunology, pp.75-79, 1997.

J. Rothers, M. Halonen, D. A. Stern, I. C. Lohman, S. Mobley et al., Adaptive cytokine production in early life differentially predicts total IgE levels 1007 and asthma through age 5 years, The Journal of allergy and clinical immunology, vol.128, issue.2, pp.397-402, 2011.

S. Saglani, L. G. Gregory, A. K. Manghera, W. J. Branchett, F. Uwadiae et al., , 1010.

. Ra, J. E. Vasiliou, R. Sherburn, S. Lui, F. Puttur et al., , p.1011

R. , F. V. Denney, L. Byrne, A. Von-mutius, E. Bush et al.,

, allergen-induced airway hyperresponsiveness is reliant on IL-13(+)CD4(+) T cells, vol.2018, p.3

Y. Fu, H. Lou, C. Wang, W. Lou, Y. Wang et al., T cell subsets in cord 1015 blood are influenced by maternal allergy and associated with atopic dermatitis. Pediatric 1016 allergy and immunology : official publication of the European Society of Pediatric Allergy and 1017, Immunology, vol.2013, issue.2, pp.178-186

M. M. Stein, C. L. Hrusch, J. Gozdz, C. Igartua, V. Pivniouk et al., , p.1019

M. Marques-dos-santos, R. L. Anderson, N. Metwali, J. W. Neilson, R. M. Maier et al., , p.1020

M. Holbreich, P. S. Thorne, F. D. Martinez, E. Von-mutius, D. Vercelli et al., Innate 1021 Immunity and Asthma Risk in Amish and Hutterite Farm Children. The New England journal 1022 of medicine, vol.375, pp.411-421, 2016.

C. M. Lloyd and B. J. Marsland, Lung Homeostasis: Influence of Age, Microbes, and the 1024 Immune System, Immunity, vol.2017, issue.4, pp.549-561

F. M. Collier, M. L. Tang, D. Martino, R. Saffery, J. Carlin et al., , p.1026

D. Burgner, K. J. Allen, P. Vuillermin, and A. L. Ponsonby, The ontogeny of naive and regulatory 1027

, CD4(+) T-cell subsets during the first postnatal year: a cohort study, Clinical & translational 1028 immunology, vol.2015, issue.3, p.34

I. H. Ismail, R. J. Boyle, L. J. Mah, P. V. Licciardi, and M. L. Tang, Reduced neonatal regulatory T 1030 cell response to microbial stimuli associates with subsequent eczema in high-risk infants

, Pediatric allergy and immunology : official publication of the European Society of Pediatric 1032, Allergy and Immunology, issue.7, pp.674-684, 2014.

B. Nibbering and N. Ubags, Microbial interactions in the atopic march, Clinical and 1034 experimental immunology, vol.2020, issue.1, pp.12-23

J. P. Mcaleer and J. K. Kolls, Contributions of the intestinal microbiome in lung immunity

, European journal of immunology, vol.2018, issue.1, pp.39-49

S. L. Russell, M. J. Gold, M. Hartmann, B. P. Willing, L. Thorson et al., , p.1038

M. R. Blanchet, W. W. Mohn, K. M. Mcnagny, and B. B. Finlay, Early life antibiotic-driven changes in 1039 microbiota enhance susceptibility to allergic asthma, EMBO reports, vol.2012, issue.13, pp.440-447

A. T. Dang and B. J. Marsland, Microbes, metabolites, and the gut-lung axis, Mucosal 1041 immunology, vol.2019, issue.4, pp.843-850

B. J. Marsland, A. Trompette, and E. S. Gollwitzer, The Gut-Lung Axis in Respiratory Disease

, Annals of the American Thoracic Society, vol.2, pp.150-156, 2015.

A. K. Ortqvist, C. Lundholm, H. Kieler, J. F. Ludvigsson, T. Fall et al.,

, Antibiotics in fetal and early life and subsequent childhood asthma: nationwide population 1046 based study with sibling analysis, Bmj, p.6979, 2014.

H. S. Deshmukh, Y. Liu, O. R. Menkiti, J. Mei, N. Dai et al., , p.1048

J. N. Weiser and G. S. Worthen, The microbiota regulates neutrophil homeostasis and host 1049 resistance to Escherichia coli K1 sepsis in neonatal mice, Nature medicine, vol.2014, issue.5, pp.524-1050

A. Trompette, E. S. Gollwitzer, K. Yadava, A. K. Sichelstiel, N. Sprenger et al., , p.1052

C. Blanchard, T. Junt, L. P. Nicod, N. L. Harris, and B. J. Marsland, Gut microbiota metabolism of 1053 dietary fiber influences allergic airway disease and hematopoiesis, Nature medicine, vol.20, issue.2, pp.159-166, 1054.

N. D. Ubags, A. Trompette, J. Pernot, B. Nibbering, N. C. Wong et al., , 1056.

L. P. Nicod, N. L. Harris, and B. J. Marsland, Microbiome-induced antigen presenting cell recruitment 1057 40 coordinates skin and lung allergic inflammation, The Journal of allergy and clinical, vol.1058, issue.2020

C. L. Olbrich, M. Bivas-benita, J. J. Xenakis, S. Maldonado, E. Cornwell et al., , p.1060

N. Gill, R. Mansfield, K. Dockstader, and L. A. Spencer, Remote allergen exposure elicits eosinophil 1061 infiltration into allergen nonexposed mucosal organs and primes for allergic inflammation

, Mucosal, vol.2020

N. D. Ubags, Remote tissue immune priming in allergic disease, Mucosal immunology, vol.1064, issue.2020

R. D. Higgins, A. H. Jobe, M. Koso-thomas, E. Bancalari, R. M. Viscardi et al., Bronchopulmonary Dysplasia: Executive 1068 Summary of a Workshop, The Journal of pediatrics, vol.197, pp.300-308, 2018.

F. Polverino, E. B. Hysinger, N. Gupta, M. Willmering, T. Olin et al.,

, Lung MRI as a Potential Complementary Diagnostic Tool for Early COPD, Am J Med, vol.2020, issue.6, pp.757-760