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Characterization of Biomaterials Intended for Use in the Nucleus Pulposus of Degenerated Intervertebral Discs

Abstract : Biomaterials for regeneration of the intervertebral disc must meet complex requirements conforming to biological, mechanical and clinical demands. Currently no consensus on their characterization exists. It is crucial to identify parameters and their method of characterization for accurate assessment of their potential efficacy, keeping in mind the translation towards clinical application. This review systematically analyzes the characterization techniques of biomaterial systems that have been used for nucleus pulposus (NP) restoration and regeneration. Substantial differences in the approach towards assessment became evident, hindering comparisons between different materials with respect to their suitability for NP restoration and regeneration. We have analyzed the current approaches and identified parameters necessary for adequate biomaterial characterization, with the clinical goal of functional restoration and biological regeneration of the NP in mind. Further, we provide guidelines and goals for their measurement.
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https://www.hal.inserm.fr/inserm-02915064
Contributor : Valérie Pecqueret <>
Submitted on : Thursday, August 13, 2020 - 3:22:37 PM
Last modification on : Tuesday, August 18, 2020 - 3:12:28 AM

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Tara Schmitz, Elias Salzer, João Crispim, Georgina Targa Fabra, Catherine Levisage, et al.. Characterization of Biomaterials Intended for Use in the Nucleus Pulposus of Degenerated Intervertebral Discs. Acta Biomaterialia, Elsevier, 2020, S1742-7061 (20), pp.30447-5. ⟨10.1016/j.actbio.2020.08.001⟩. ⟨inserm-02915064⟩

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